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RHOU and TCN2
Number of citations of the paper that reports this interaction (PubMedID
26598620
)
63
Data Source:
BioGRID
(pull down)
RHOU
TCN2
Description
ras homolog family member U
transcobalamin 2
Image
GO Annotations
Cellular Component
Golgi Membrane
Podosome
Golgi Apparatus
Cytosol
Plasma Membrane
Focal Adhesion
Endosome Membrane
Membrane
Cell Projection
Anchoring Junction
Extracellular Region
Extracellular Space
Plasma Membrane
External Side Of Plasma Membrane
Lysosomal Lumen
Molecular Function
Nucleotide Binding
GTPase Activity
Guanyl-nucleotide Exchange Factor Activity
Protein Binding
GTP Binding
Protein Kinase Binding
Protein-macromolecule Adaptor Activity
Metal Ion Binding
Protein Binding
Cobalamin Binding
Metal Ion Binding
Molecular Carrier Activity
Cargo Receptor Ligand Activity
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Endocytosis
Cytoskeleton Organization
Actin Filament Organization
Signal Transduction
Small GTPase-mediated Signal Transduction
Regulation Of Cell Shape
Rac Protein Signal Transduction
Establishment Of Cell Polarity
Actin Cytoskeleton Organization
Regulation Of Small GTPase Mediated Signal Transduction
Positive Regulation Of Focal Adhesion Disassembly
Positive Regulation Of Protein Targeting To Mitochondrion
Monoatomic Ion Transport
Cobalt Ion Transport
Cobalamin Transport
Pathways
Interleukin-4 and Interleukin-13 signaling
RHOU GTPase cycle
RHOU GTPase cycle
Defective TCN2 causes TCN2 deficiency
Defective CD320 causes MMATC
Transport of RCbl within the body
Drugs
Diseases
GWAS
Aging (
22773346
)
Basal cell carcinoma (
18849993
24403052
25855136
27539887
33549134
)
Chronic lymphocytic leukemia (
28165464
)
Dental caries (
23259602
)
Endometriosis (
20844546
)
Leukoderma in response to rhododendrol (
32558222
)
Mercury levels (
26025379
)
Non-melanoma skin cancer (
29739929
)
Response to antidepressants in depression (
27622933
)
Type 2 diabetes (
23300278
)
Blood protein levels (
30072576
)
Factor VIII levels (
30586737
)
Gut microbiota relative abundance (Blautia) (
33208821
)
Moyamoya disease (
29273593
)
Type 2 diabetes (
32794382
)
Venous thromboembolism (
31420334
)
vWF levels (
30586737
)
Interacting Genes
126 interacting genes:
ACAD8
ADM2
ALG13
ANGPT4
ANXA4
ANXA6
AP1S1
ARHGEF25
AS3MT
ATP5MG
ATP6AP1
BDNF
BMAL1
BNIPL
BRF1
BRINP3
C14orf119
CDKL4
CFAP100
CHRNA4
CLEC7A
CPNE3
CTCF
CUL5
DACT2
DMRT2
DNM2
DOK4
DSCR8
EIF4B
ELP5
EMC2
ERF
ERO1A
FAM110B
FCHO2
FKBP15
GALNTL5
GLI3
GPRIN2
GRB2
H2BC14
HCAR1
HINT3
HSD17B13
ID2
IFFO1
IL17F
INSM2
JAM3
KAAG1
KIAA1191
KLRC3
LANCL2
LARS2
LAYN
LMO7
LYL1
ME3
MOS
MRAS
MRPL15
NCK1
NCR1
NPM3
NR1H2
NRBF2
NXPH4
OXCT2
P4HTM
PAK1
PAK4
PCDHGA4
PDLIM3
PGK1
PIP5K1A
PLCG1
PLEK
PLOD3
POT1
PRB1
PRPF18
PSMA4
PXN
QTRT1
RAB40A
RAD51D
RALBP1
RASSF1
RBIS
RPL23AP5
RPS15A
RPS17P16
S100A4
SEC14L4
SEMA3G
SEPTIN6
SIVA1
SKIC2
SLC26A1
SNU13
SOX4
SSC4D
STX16
SYK
TCN2
TEKT2
TMEM106A
TMEM169
TMEM255B
TRIM59
USP37
UTP3
VWA5A
WNT6
XPA
ZFAND2B
ZFP64
ZKSCAN7
ZNF117
ZNF177
ZNF20
ZNF569
ZNF625
ZNF747
ZNF84
4 interacting genes:
APP
CBL
PAXIP1
RHOU
Entrez ID
58480
6948
HPRD ID
06965
02037
Ensembl ID
ENSG00000116574
ENSG00000185339
Uniprot IDs
Q7L0Q8
P20062
PDB IDs
2Q3H
2BB5
4ZRP
4ZRQ
5NO0
5NP4
5NRP
5NSA
7QBD
7QBE
7QBF
7QBG
Enriched GO Terms of Interacting Partners
?
Stimulatory C-type Lectin Receptor Signaling Pathway
Cellular Response To Lectin
Response To Nerve Growth Factor
Ephrin Receptor Binding
Positive Regulation Of Receptor-mediated Endocytosis
Vesicle-mediated Transport
Cellular Response To Nerve Growth Factor Stimulus
Endocytosis
Response To Radiation
Amyloid-beta Complex
Growth Cone Lamellipodium
Regulation Of Response To Calcium Ion
Amylin Binding
Positive Regulation Of Toll Signaling Pathway
Acetylcholine Receptor Activator Activity
PTB Domain Binding
Collateral Sprouting In Absence Of Injury
Regulation Of Protein Import
Endosome To Plasma Membrane Transport Vesicle
Positive Regulation Of Endothelin Production
Positive Regulation Of Endocytosis
Growth Cone Filopodium
Growth Cone
Regulation Of Receptor-mediated Endocytosis
Lipoprotein Particle
Import Into Cell
Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Protein Import
Microglia Development
Positive Regulation Of G Protein-coupled Receptor Internalization
Response To Ionizing Radiation
Chorion Development
Membrane Raft
Response To Norepinephrine
Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Intermediate-density Lipoprotein Particle
Early Endosome Membrane
Axon Midline Choice Point Recognition
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Amyloid Fibril Formation
Cellular Response To Norepinephrine Stimulus
Growth Factor Receptor Binding
Main Axon
Astrocyte Activation Involved In Immune Response
Low-density Lipoprotein Particle Mediated Signaling
Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway
Regulation Of Rap Protein Signal Transduction
Regulation Of Spontaneous Synaptic Transmission
NMDA Selective Glutamate Receptor Signaling Pathway
Regulation Of Synapse Structure Or Activity
Regulation Of Toll Signaling Pathway
Ubiquitin-dependent Endocytosis
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Tagcloud (Difference)
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Tagcloud (Intersection)
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