RHOU and ANGPT4

Number of citations of the paper that reports this interaction (PubMedID 26598620)
63

Data Source:
BioGRID (pull down)

		RHOU	ANGPT4
Description		ras homolog family member U	angiopoietin 4
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Podosome Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Endosome Membrane Membrane Cell Projection Anchoring Junction	Extracellular Region Extracellular Space Extracellular Matrix
	Molecular Function	Nucleotide Binding GTPase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Metal Ion Binding	Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Receptor Tyrosine Kinase Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Endocytosis Cytoskeleton Organization Actin Filament Organization Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Cell Shape Rac Protein Signal Transduction Establishment Of Cell Polarity Actin Cytoskeleton Organization Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Focal Adhesion Disassembly Positive Regulation Of Protein Targeting To Mitochondrion	Angiogenesis Endothelial Cell Proliferation Signal Transduction Notch Signaling Pathway Blood Coagulation Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Angiogenesis Negative Regulation Of Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cellular Response To Hypoxia
Pathways		Interleukin-4 and Interleukin-13 signaling RHOU GTPase cycle RHOU GTPase cycle	Tie2 Signaling
Drugs
Diseases
GWAS		Aging ( 22773346) Basal cell carcinoma ( 18849993 24403052 25855136 27539887 33549134) Chronic lymphocytic leukemia ( 28165464) Dental caries ( 23259602) Endometriosis ( 20844546) Leukoderma in response to rhododendrol ( 32558222) Mercury levels ( 26025379) Non-melanoma skin cancer ( 29739929) Response to antidepressants in depression ( 27622933) Type 2 diabetes ( 23300278)	Food allergy ( 29030101) Intracranial aneurysm ( 29531279) Logical memory (immediate recall) in Alzheimer's disease dementia ( 29274321) Lung function ( 31902109) Peanut allergy ( 29030101)
Interacting Genes		126 interacting genes: ACAD8 ADM2 ALG13 ANGPT4 ANXA4 ANXA6 AP1S1 ARHGEF25 AS3MT ATP5MG ATP6AP1 BDNF BMAL1 BNIPL BRF1 BRINP3 C14orf119 CDKL4 CFAP100 CHRNA4 CLEC7A CPNE3 CTCF CUL5 DACT2 DMRT2 DNM2 DOK4 DSCR8 EIF4B ELP5 EMC2 ERF ERO1A FAM110B FCHO2 FKBP15 GALNTL5 GLI3 GPRIN2 GRB2 H2BC14 HCAR1 HINT3 HSD17B13 ID2 IFFO1 IL17F INSM2 JAM3 KAAG1 KIAA1191 KLRC3 LANCL2 LARS2 LAYN LMO7 LYL1 ME3 MOS MRAS MRPL15 NCK1 NCR1 NPM3 NR1H2 NRBF2 NXPH4 OXCT2 P4HTM PAK1 PAK4 PCDHGA4 PDLIM3 PGK1 PIP5K1A PLCG1 PLEK PLOD3 POT1 PRB1 PRPF18 PSMA4 PXN QTRT1 RAB40A RAD51D RALBP1 RASSF1 RBIS RPL23AP5 RPS15A RPS17P16 S100A4 SEC14L4 SEMA3G SEPTIN6 SIVA1 SKIC2 SLC26A1 SNU13 SOX4 SSC4D STX16 SYK TCN2 TEKT2 TMEM106A TMEM169 TMEM255B TRIM59 USP37 UTP3 VWA5A WNT6 XPA ZFAND2B ZFP64 ZKSCAN7 ZNF117 ZNF177 ZNF20 ZNF569 ZNF625 ZNF747 ZNF84	3 interacting genes: RHOU TEK TIE1
Entrez ID		58480	51378
HPRD ID		06965	04747
Ensembl ID		ENSG00000116574	ENSG00000101280
Uniprot IDs		Q7L0Q8	Q9Y264
PDB IDs		2Q3H
Enriched GO Terms of Interacting Partners?		Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin	Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Cell-substrate Junction Organization Blood Vessel Development Regulation Of Anatomical Structure Morphogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Protein Tyrosine Kinase Activity Regulation Of Endothelial Cell Proliferation Branching Involved In Lymph Vessel Morphogenesis Positive Regulation Of Vasculature Development Positive Regulation Of Angiogenesis Receptor Complex Tie Signaling Pathway Nucleotide Binding Regulation Of Angiogenesis Glomerulus Vasculature Development Regulation Of Small GTPase Mediated Signal Transduction Angiogenesis Regulation Of Vasculature Development Lymphatic Endothelial Cell Differentiation Regulation Of Epithelial Cell Proliferation Positive Regulation Of Focal Adhesion Disassembly Anchoring Junction Focal Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Heart Trabecula Formation Protein Kinase Activity Regulation Of Developmental Process Definitive Hemopoiesis Regulation Of Cellular Component Organization Positive Regulation Of Rac Protein Signal Transduction Plasma Membrane Fusion Kinase Activity Regulation Of Extracellular Matrix Assembly Enzyme-linked Receptor Protein Signaling Pathway Rac Protein Signal Transduction Regulation Of Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of Focal Adhesion Assembly Endothelial Cell Differentiation Sprouting Angiogenesis Negative Regulation Of Endothelial Cell Apoptotic Process Endothelial Cell Proliferation Regulation Of Rac Protein Signal Transduction Anatomical Structure Formation Involved In Morphogenesis Aortic Valve Morphogenesis Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Positive Regulation Of Protein Targeting To Mitochondrion Podosome Regulation Of Protein Targeting To Mitochondrion
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