RHOU and IL17F

Number of citations of the paper that reports this interaction (PubMedID 26598620)
63

Data Source:
BioGRID (pull down)

		RHOU	IL17F
Description		ras homolog family member U	interleukin 17F
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GO Annotations	Cellular Component	Golgi Membrane Podosome Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Endosome Membrane Membrane Cell Projection Anchoring Junction	Extracellular Region Extracellular Space
	Molecular Function	Nucleotide Binding GTPase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Metal Ion Binding	Cytokine Activity Cytokine Receptor Binding Protein Binding Cytokine Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Endocytosis Cytoskeleton Organization Actin Filament Organization Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Cell Shape Rac Protein Signal Transduction Establishment Of Cell Polarity Actin Cytoskeleton Organization Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Focal Adhesion Disassembly Positive Regulation Of Protein Targeting To Mitochondrion	Positive Regulation Of Cytokine Production Positive Regulation Of Antimicrobial Peptide Production Adaptive Immune Response Immune System Process Inflammatory Response Negative Regulation Of Angiogenesis Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Regulation Of Interleukin-2 Production Regulation Of Interleukin-6 Production Regulation Of Interleukin-8 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Lymphotoxin A Production Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Cartilage Development Regulation Of Primary Metabolic Process Interleukin-17-mediated Signaling Pathway Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production
Pathways		Interleukin-4 and Interleukin-13 signaling RHOU GTPase cycle RHOU GTPase cycle	Interleukin-17 signaling Interleukin-4 and Interleukin-13 signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs			Bimekizumab
Diseases			Chronic Mucocutaneous Candidiasis (CMC); Familial candidiasis (CANDF)
GWAS		Aging ( 22773346) Basal cell carcinoma ( 18849993 24403052 25855136 27539887 33549134) Chronic lymphocytic leukemia ( 28165464) Dental caries ( 23259602) Endometriosis ( 20844546) Leukoderma in response to rhododendrol ( 32558222) Mercury levels ( 26025379) Non-melanoma skin cancer ( 29739929) Response to antidepressants in depression ( 27622933) Type 2 diabetes ( 23300278)	Cryptococcosis in HIV infection ( 33269293) Initial alcohol sensitivity ( 30276832) Response to gemcitabine in pancreatic cancer ( 22142827) Survival in pancreatic cancer ( 28470677)
Interacting Genes		126 interacting genes: ACAD8 ADM2 ALG13 ANGPT4 ANXA4 ANXA6 AP1S1 ARHGEF25 AS3MT ATP5MG ATP6AP1 BDNF BMAL1 BNIPL BRF1 BRINP3 C14orf119 CDKL4 CFAP100 CHRNA4 CLEC7A CPNE3 CTCF CUL5 DACT2 DMRT2 DNM2 DOK4 DSCR8 EIF4B ELP5 EMC2 ERF ERO1A FAM110B FCHO2 FKBP15 GALNTL5 GLI3 GPRIN2 GRB2 H2BC14 HCAR1 HINT3 HSD17B13 ID2 IFFO1 IL17F INSM2 JAM3 KAAG1 KIAA1191 KLRC3 LANCL2 LARS2 LAYN LMO7 LYL1 ME3 MOS MRAS MRPL15 NCK1 NCR1 NPM3 NR1H2 NRBF2 NXPH4 OXCT2 P4HTM PAK1 PAK4 PCDHGA4 PDLIM3 PGK1 PIP5K1A PLCG1 PLEK PLOD3 POT1 PRB1 PRPF18 PSMA4 PXN QTRT1 RAB40A RAD51D RALBP1 RASSF1 RBIS RPL23AP5 RPS15A RPS17P16 S100A4 SEC14L4 SEMA3G SEPTIN6 SIVA1 SKIC2 SLC26A1 SNU13 SOX4 SSC4D STX16 SYK TCN2 TEKT2 TMEM106A TMEM169 TMEM255B TRIM59 USP37 UTP3 VWA5A WNT6 XPA ZFAND2B ZFP64 ZKSCAN7 ZNF117 ZNF177 ZNF20 ZNF569 ZNF625 ZNF747 ZNF84	2 interacting genes: GMCL1 RHOU
Entrez ID		58480	112744
HPRD ID		06965	16224
Ensembl ID		ENSG00000116574	ENSG00000112116
Uniprot IDs		Q7L0Q8	Q96PD4
PDB IDs		2Q3H	1JPY 3JVF 5N92 5NAN 6HG4 6HG9 6HGO 6PPG 8RUU
Enriched GO Terms of Interacting Partners?		Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin
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