SIVA1 and TNFRSF4

Number of citations of the paper that reports this interaction (PMID 12478477)
14

Data Source:
HPRD (in vitro)

		SIVA1	TNFRSF4
Gene Name		SIVA1, apoptosis-inducing factor	tumor necrosis factor receptor superfamily, member 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion	Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface
	Molecular Function	Virus Receptor Activity CD27 Receptor Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Tumor Necrosis Factor-activated Receptor Activity
	Biological Process	Activation-induced Cell Death Of T Cells Response To Virus Viral Process Negative Regulation Of NF-kappaB Transcription Factor Activity Extrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway	Inflammatory Response Immune Response Cellular Defense Response Positive Regulation Of B Cell Proliferation Tumor Necrosis Factor-mediated Signaling Pathway T Cell Proliferation Regulation Of Apoptotic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Cytokine Secretion Positive Regulation Of Immunoglobulin Secretion
Pathways
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		18 interactors: ABL2 APP BCL2L1 CD27 CD4 CDKN2A MEFV NEDD4 NEDD4L NGFRAP1 PCNA POLR2M PXMP2 RAD18 STMN1 TCAP TNFRSF4 UBE2D1	8 interactors: SIVA1 TNFRSF9 TNFSF4 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5
Entrez ID		10572	7293
HPRD ID		16124	02636
Ensembl ID		ENSG00000184990	ENSG00000186827
Uniprot IDs		O15304	P43489
PDB IDs			1D0A 2HEV 2HEY
Enriched GO Terms of Interacting Partners?		Response To Stress Immune Response Response To Abiotic Stimulus Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Cellular Response To Stimulus Regulation Of Catalytic Activity Positive Regulation Of Proteolysis Response To Stimulus Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Peptidase Activity Regulation Of Cellular Localization Positive Regulation Of Metabolic Process Regulation Of Proteolysis Positive Regulation Of Catalytic Activity Negative Regulation Of Cellular Metabolic Process Protein Polyubiquitination Signal Transduction Regulation Of Endopeptidase Activity Immune System Process Regulation Of Peptidase Activity Intracellular Receptor Signaling Pathway Response To Radiation Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Protein Localization Signaling Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Neuron Remodeling Cell Communication Cell Surface Receptor Signaling Pathway Negative Regulation Of Sodium Ion Transport Defense Response Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Modulation By Virus Of Host Process T Cell Aggregation T Cell Activation Protein Ubiquitination Lymphocyte Aggregation Leukocyte Aggregation Interaction With Host Extrinsic Apoptotic Signaling Pathway Programmed Cell Death Regulation Of Metabolic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Hydrolase Activity Cell Death Leukocyte Cell-cell Adhesion	Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Apoptotic Process Regulation Of Cell Death Positive Regulation Of Protein Homodimerization Activity Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Immunoglobulin Secretion Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homotrimerization Positive Regulation Of T Cell Cytokine Production Regulation Of Cytokine Production Regulation Of Protein Homodimerization Activity Activation Of NF-kappaB-inducing Kinase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of T Cell Cytokine Production Negative Regulation Of Cytokine Production Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Tumor Necrosis Factor-mediated Signaling Pathway NIK/NF-kappaB Signaling Regulation Of NIK/NF-kappaB Signaling Protein Trimerization Positive Regulation Of Interleukin-2 Production Negative Regulation Of Cytokine Secretion Positive Regulation Of Cytokine Production Involved In Immune Response Signal Transduction Negative Regulation Of NF-kappaB Transcription Factor Activity TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Interleukin-12 Production Regulation Of Cellular Localization Positive Regulation Of Protein Binding MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Protein Secretion Regulation Of Cytokine Production Involved In Immune Response Signaling Cell Communication Toll-like Receptor 4 Signaling Pathway Positive Regulation Of CD4-positive, Alpha-beta T Cell Costimulation Cellular Response To Nitrogen Dioxide Response To Nitrogen Dioxide T-helper 2 Cell Activation Positive Regulation Of Interleukin-4-dependent Isotype Switching To IgE Isotypes CD4-positive, Alpha-beta T Cell Costimulation Memory T Cell Activation Cellular Response To Tumor Necrosis Factor
Tagcloud ?		accelerates advance closure coexpression cutaneous dermatology doi donut downregulate electrical epidermis epithelialization es explants hdm2 healing investigative jid journal keratinocyte minute obscure phospho publication shaped stratification upregulating wound wounds	assembles bcl10 carma1 cbm cd134 cd252 cd28 contributor detergent dim directs expand malt1 microdomains ox40 ox40l persist pkctheta primed rafts raising rip1 signalosome superfamily tcr translocates works
Tagcloud (Difference) ?		accelerates advance closure coexpression cutaneous dermatology doi donut downregulate electrical epidermis epithelialization es explants hdm2 healing investigative jid journal keratinocyte minute obscure phospho publication shaped stratification upregulating wound wounds	assembles bcl10 carma1 cbm cd134 cd252 cd28 contributor detergent dim directs expand malt1 microdomains ox40 ox40l persist pkctheta primed rafts raising rip1 signalosome superfamily tcr translocates works
Tagcloud (Intersection) ?