RHOU and ARHGEF25

Number of citations of the paper that reports this interaction (PubMedID 26598620)
63

Data Source:
BioGRID (pull down)

		RHOU	ARHGEF25
Description		ras homolog family member U	Rho guanine nucleotide exchange factor 25
Image
GO Annotations	Cellular Component	Golgi Membrane Podosome Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Endosome Membrane Membrane Cell Projection Anchoring Junction	Cytoplasm Cytosol Plasma Membrane Membrane Extrinsic Component Of Membrane Myofibril Sarcomere
	Molecular Function	Nucleotide Binding GTPase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Metal Ion Binding	Guanyl-nucleotide Exchange Factor Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Endocytosis Cytoskeleton Organization Actin Filament Organization Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Cell Shape Rac Protein Signal Transduction Establishment Of Cell Polarity Actin Cytoskeleton Organization Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Focal Adhesion Disassembly Positive Regulation Of Protein Targeting To Mitochondrion	Axon Guidance Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Interleukin-4 and Interleukin-13 signaling RHOU GTPase cycle RHOU GTPase cycle	G alpha (q) signalling events RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Aging ( 22773346) Basal cell carcinoma ( 18849993 24403052 25855136 27539887 33549134) Chronic lymphocytic leukemia ( 28165464) Dental caries ( 23259602) Endometriosis ( 20844546) Leukoderma in response to rhododendrol ( 32558222) Mercury levels ( 26025379) Non-melanoma skin cancer ( 29739929) Response to antidepressants in depression ( 27622933) Type 2 diabetes ( 23300278)	Systolic blood pressure ( 30224653 30578418)
Interacting Genes		126 interacting genes: ACAD8 ADM2 ALG13 ANGPT4 ANXA4 ANXA6 AP1S1 ARHGEF25 AS3MT ATP5MG ATP6AP1 BDNF BMAL1 BNIPL BRF1 BRINP3 C14orf119 CDKL4 CFAP100 CHRNA4 CLEC7A CPNE3 CTCF CUL5 DACT2 DMRT2 DNM2 DOK4 DSCR8 EIF4B ELP5 EMC2 ERF ERO1A FAM110B FCHO2 FKBP15 GALNTL5 GLI3 GPRIN2 GRB2 H2BC14 HCAR1 HINT3 HSD17B13 ID2 IFFO1 IL17F INSM2 JAM3 KAAG1 KIAA1191 KLRC3 LANCL2 LARS2 LAYN LMO7 LYL1 ME3 MOS MRAS MRPL15 NCK1 NCR1 NPM3 NR1H2 NRBF2 NXPH4 OXCT2 P4HTM PAK1 PAK4 PCDHGA4 PDLIM3 PGK1 PIP5K1A PLCG1 PLEK PLOD3 POT1 PRB1 PRPF18 PSMA4 PXN QTRT1 RAB40A RAD51D RALBP1 RASSF1 RBIS RPL23AP5 RPS15A RPS17P16 S100A4 SEC14L4 SEMA3G SEPTIN6 SIVA1 SKIC2 SLC26A1 SNU13 SOX4 SSC4D STX16 SYK TCN2 TEKT2 TMEM106A TMEM169 TMEM255B TRIM59 USP37 UTP3 VWA5A WNT6 XPA ZFAND2B ZFP64 ZKSCAN7 ZNF117 ZNF177 ZNF20 ZNF569 ZNF625 ZNF747 ZNF84	5 interacting genes: CDC42 PRKCG RAC1 RHOA RHOU
Entrez ID		58480	115557
HPRD ID		06965	13573
Ensembl ID		ENSG00000116574	ENSG00000240771
Uniprot IDs		Q7L0Q8	Q86VW2
PDB IDs		2Q3H	2RGN
Enriched GO Terms of Interacting Partners?		Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin	Establishment Or Maintenance Of Cell Polarity Wnt Signaling Pathway, Planar Cell Polarity Pathway Actin Filament Organization Small GTPase-mediated Signal Transduction Positive Regulation Of Stress Fiber Assembly Membrane Invagination Non-canonical Wnt Signaling Pathway Positive Regulation Of Actin Filament Bundle Assembly GTPase Activity G Protein Activity Regulation Of Cell-substrate Junction Organization GTP Binding Actin Cytoskeleton Organization Establishment Of Cell Polarity Actin Filament-based Process G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Regulation Of Stress Fiber Assembly Focal Adhesion Cell Projection Protein Kinase Binding Dendrite Thioesterase Binding Supramolecular Fiber Organization Positive Regulation Of Supramolecular Fiber Organization Establishment Of Epithelial Cell Apical/basal Polarity Nucleotide Binding Cell-cell Junction Organization Intracellular Signal Transduction Positive Regulation Of Cytoskeleton Organization GTP-dependent Protein Binding Establishment Of Apical/basal Cell Polarity Polarized Epithelial Cell Differentiation Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Regulation Of Cell-substrate Adhesion Rac Protein Signal Transduction Postsynapse Positive Regulation Of Lamellipodium Assembly Cerebral Cortex Cell Migration Intracellular Signaling Cassette Establishment Of Epithelial Cell Polarity Phagocytosis, Engulfment Regulation Of Actin Filament Organization Wnt Signaling Pathway Positive Regulation Of Lamellipodium Organization Regulation Of Lamellipodium Assembly Cytoskeleton Organization Regulation Of Synapse Organization Regulation Of Cellular Component Organization Telencephalon Cell Migration
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