RHOU and AP1S1

Number of citations of the paper that reports this interaction (PubMedID 26598620)
63

Data Source:
BioGRID (pull down)

		RHOU	AP1S1
Description		ras homolog family member U	adaptor related protein complex 1 subunit sigma 1
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GO Annotations	Cellular Component	Golgi Membrane Podosome Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Endosome Membrane Membrane Cell Projection Anchoring Junction	Golgi Membrane Lysosomal Membrane Early Endosome Golgi Apparatus Cytosol Clathrin-coated Pit Membrane Membrane Coat AP-1 Adaptor Complex Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane Terminal Bouton Intracellular Membrane-bounded Organelle Presynapse
	Molecular Function	Nucleotide Binding GTPase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Metal Ion Binding	Protein Binding Clathrin Adaptor Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Endocytosis Cytoskeleton Organization Actin Filament Organization Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Cell Shape Rac Protein Signal Transduction Establishment Of Cell Polarity Actin Cytoskeleton Organization Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Focal Adhesion Disassembly Positive Regulation Of Protein Targeting To Mitochondrion	Intracellular Protein Transport Receptor-mediated Endocytosis Response To Virus Protein Transport Vesicle-mediated Transport Retrograde Transport, Endosome To Golgi Platelet Dense Granule Organization Basolateral Protein Secretion Melanosome Assembly
Pathways		Interleukin-4 and Interleukin-13 signaling RHOU GTPase cycle RHOU GTPase cycle	Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis
Drugs
Diseases
GWAS		Aging ( 22773346) Basal cell carcinoma ( 18849993 24403052 25855136 27539887 33549134) Chronic lymphocytic leukemia ( 28165464) Dental caries ( 23259602) Endometriosis ( 20844546) Leukoderma in response to rhododendrol ( 32558222) Mercury levels ( 26025379) Non-melanoma skin cancer ( 29739929) Response to antidepressants in depression ( 27622933) Type 2 diabetes ( 23300278)	Adult body size ( 32376654) Serum metabolite concentrations in chronic kidney disease ( 33838163)
Interacting Genes		126 interacting genes: ACAD8 ADM2 ALG13 ANGPT4 ANXA4 ANXA6 AP1S1 ARHGEF25 AS3MT ATP5MG ATP6AP1 BDNF BMAL1 BNIPL BRF1 BRINP3 C14orf119 CDKL4 CFAP100 CHRNA4 CLEC7A CPNE3 CTCF CUL5 DACT2 DMRT2 DNM2 DOK4 DSCR8 EIF4B ELP5 EMC2 ERF ERO1A FAM110B FCHO2 FKBP15 GALNTL5 GLI3 GPRIN2 GRB2 H2BC14 HCAR1 HINT3 HSD17B13 ID2 IFFO1 IL17F INSM2 JAM3 KAAG1 KIAA1191 KLRC3 LANCL2 LARS2 LAYN LMO7 LYL1 ME3 MOS MRAS MRPL15 NCK1 NCR1 NPM3 NR1H2 NRBF2 NXPH4 OXCT2 P4HTM PAK1 PAK4 PCDHGA4 PDLIM3 PGK1 PIP5K1A PLCG1 PLEK PLOD3 POT1 PRB1 PRPF18 PSMA4 PXN QTRT1 RAB40A RAD51D RALBP1 RASSF1 RBIS RPL23AP5 RPS15A RPS17P16 S100A4 SEC14L4 SEMA3G SEPTIN6 SIVA1 SKIC2 SLC26A1 SNU13 SOX4 SSC4D STX16 SYK TCN2 TEKT2 TMEM106A TMEM169 TMEM255B TRIM59 USP37 UTP3 VWA5A WNT6 XPA ZFAND2B ZFP64 ZKSCAN7 ZNF117 ZNF177 ZNF20 ZNF569 ZNF625 ZNF747 ZNF84	6 interacting genes: AP1G1 AP1G2 AP1M2 AP2A2 PICK1 RHOU
Entrez ID		58480	1174
HPRD ID		06965	04635
Ensembl ID		ENSG00000116574	ENSG00000106367
Uniprot IDs		Q7L0Q8	P61966
PDB IDs		2Q3H	4P6Z
Enriched GO Terms of Interacting Partners?		Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin	Clathrin Adaptor Activity AP-1 Adaptor Complex Membrane Coat Intracellular Protein Transport Basolateral Protein Secretion Clathrin Adaptor Complex Trans-Golgi Network Membrane Protein Transport Vesicle-mediated Transport Intracellular Transport Intracellular Vesicle Golgi To Vacuole Transport Cytoplasmic Vesicle Membrane Establishment Of Protein Localization Golgi Apparatus Golgi Membrane Clathrin-coated Vesicle Membrane Synaptic Vesicle Endocytosis Cellular Localization Establishment Of Localization In Cell Presynaptic Endocytosis Cytoplasmic Vesicle Intracellular Protein Localization Clathrin-coated Pit Endocytic Vesicle Membrane Clathrin-coated Vesicle Endocytosis Vesicle-mediated Transport In Synapse Post-Golgi Vesicle-mediated Transport Synaptic Vesicle Budding From Endosome Protein Localization To Extracellular Region Establishment Of Protein Localization To Extracellular Region Protein Secretion Import Into Cell Membrane Membrane Curvature Sensor Activity Vacuolar Transport Positive Regulation Of Natural Killer Cell Degranulation Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Postsynaptic Neurotransmitter Receptor Internalization Negative Regulation Of Actin Nucleation Positive Regulation Of Focal Adhesion Disassembly Protein Domain Specific Binding Presynapse Endosome To Melanosome Transport AP-2 Adaptor Complex Golgi To Lysosome Transport Neuronal Ion Channel Clustering Dendritic Spine Maintenance Synapse
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