RHOU and PIP5K1A

Number of citations of the paper that reports this interaction (PubMedID 26598620)
63

Data Source:
BioGRID (pull down)

		RHOU	PIP5K1A
Description		ras homolog family member U	phosphatidylinositol-4-phosphate 5-kinase type 1 alpha
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Podosome Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Endosome Membrane Membrane Cell Projection Anchoring Junction	Ruffle Nucleus Nucleoplasm Cytoplasm Cytosol MRNA Cleavage And Polyadenylation Specificity Factor Complex Plasma Membrane Focal Adhesion Membrane Nuclear Speck Lamellipodium Ruffle Membrane Cell Projection
	Molecular Function	Nucleotide Binding GTPase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Metal Ion Binding	Nucleotide Binding 1-phosphatidylinositol-3-phosphate 5-kinase Activity Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-4-phosphate 5-kinase Activity Transferase Activity Kinase Binding Phosphatidylinositol Kinase Activity 1-phosphatidylinositol-5-kinase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Endocytosis Cytoskeleton Organization Actin Filament Organization Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Cell Shape Rac Protein Signal Transduction Establishment Of Cell Polarity Actin Cytoskeleton Organization Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Focal Adhesion Disassembly Positive Regulation Of Protein Targeting To Mitochondrion	Lipid Metabolic Process Glycerophospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phagocytosis Signal Transduction Phospholipid Biosynthetic Process Fibroblast Migration Cell Migration Actin Cytoskeleton Organization Keratinocyte Differentiation Phosphatidylinositol Metabolic Process Phosphatidylinositol Phosphate Biosynthetic Process Focal Adhesion Assembly Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Chemotaxis Protein Localization To Plasma Membrane Activation Of GTPase Activity Ruffle Assembly
Pathways		Interleukin-4 and Interleukin-13 signaling RHOU GTPase cycle RHOU GTPase cycle	Synthesis of PIPs at the plasma membrane PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs
Diseases
GWAS		Aging ( 22773346) Basal cell carcinoma ( 18849993 24403052 25855136 27539887 33549134) Chronic lymphocytic leukemia ( 28165464) Dental caries ( 23259602) Endometriosis ( 20844546) Leukoderma in response to rhododendrol ( 32558222) Mercury levels ( 26025379) Non-melanoma skin cancer ( 29739929) Response to antidepressants in depression ( 27622933) Type 2 diabetes ( 23300278)	Body mass index ( 26426971)
Interacting Genes		126 interacting genes: ACAD8 ADM2 ALG13 ANGPT4 ANXA4 ANXA6 AP1S1 ARHGEF25 AS3MT ATP5MG ATP6AP1 BDNF BMAL1 BNIPL BRF1 BRINP3 C14orf119 CDKL4 CFAP100 CHRNA4 CLEC7A CPNE3 CTCF CUL5 DACT2 DMRT2 DNM2 DOK4 DSCR8 EIF4B ELP5 EMC2 ERF ERO1A FAM110B FCHO2 FKBP15 GALNTL5 GLI3 GPRIN2 GRB2 H2BC14 HCAR1 HINT3 HSD17B13 ID2 IFFO1 IL17F INSM2 JAM3 KAAG1 KIAA1191 KLRC3 LANCL2 LARS2 LAYN LMO7 LYL1 ME3 MOS MRAS MRPL15 NCK1 NCR1 NPM3 NR1H2 NRBF2 NXPH4 OXCT2 P4HTM PAK1 PAK4 PCDHGA4 PDLIM3 PGK1 PIP5K1A PLCG1 PLEK PLOD3 POT1 PRB1 PRPF18 PSMA4 PXN QTRT1 RAB40A RAD51D RALBP1 RASSF1 RBIS RPL23AP5 RPS15A RPS17P16 S100A4 SEC14L4 SEMA3G SEPTIN6 SIVA1 SKIC2 SLC26A1 SNU13 SOX4 SSC4D STX16 SYK TCN2 TEKT2 TMEM106A TMEM169 TMEM255B TRIM59 USP37 UTP3 VWA5A WNT6 XPA ZFAND2B ZFP64 ZKSCAN7 ZNF117 ZNF177 ZNF20 ZNF569 ZNF625 ZNF747 ZNF84	16 interacting genes: APP ARF1 ARF5 ARF6 BTK CADPS CASP3 KRAS MIR140 MIR34B NEDD4 PIP5KL1 PLD1 PLD2 RHOU TEC
Entrez ID		58480	8394
HPRD ID		06965	04470
Ensembl ID		ENSG00000116574	ENSG00000143398
Uniprot IDs		Q7L0Q8	A6PW57 Q99755
PDB IDs		2Q3H
Enriched GO Terms of Interacting Partners?		Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin	Regulation Of Vesicle-mediated Transport Regulation Of Transport Regulation Of Biological Quality Vesicle-mediated Transport Intracellular Signal Transduction GTPase Activity Phospholipase D Activity GTP Binding Regulation Of Intracellular Signal Transduction Positive Regulation Of Focal Adhesion Disassembly Establishment Of Localization In Cell Endocytosis Presynapse Plasma Membrane Nucleotide Binding Intracellular Signaling Cassette Response To External Biotic Stimulus Intracellular Copper Ion Homeostasis Golgi Apparatus Regulation Of Synaptic Vesicle Cycle Small GTPase-mediated Signal Transduction Negative Regulation Of B Cell Proliferation Copper Ion Homeostasis Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Endocytosis Response To Light Stimulus Regulation Of Receptor-mediated Endocytosis Import Into Cell Response To Molecule Of Bacterial Origin Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Presynapse Assembly Regulation Of Cell Communication Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Signaling Rac Protein Signal Transduction Phosphatidic Acid Biosynthetic Process Perinuclear Region Of Cytoplasm Regulation Of Interleukin-6 Production Negative Regulation Of Cell Population Proliferation Phosphatidic Acid Metabolic Process Regulation Of Rac Protein Signal Transduction Negative Regulation Of B Cell Activation Positive Regulation Of Inflammatory Response Glycerophospholipid Biosynthetic Process Regulation Of Tumor Necrosis Factor Production Focal Adhesion Regulation Of Signal Transduction MiRNA-mediated Gene Silencing By MRNA Destabilization Response To Radiation
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