RHOU and NPM3

Number of citations of the paper that reports this interaction (PubMedID 26598620)
63

Data Source:
BioGRID (pull down)

		RHOU	NPM3
Description		ras homolog family member U	nucleophosmin/nucleoplasmin 3
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Podosome Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Endosome Membrane Membrane Cell Projection Anchoring Junction	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Actin Cytoskeleton
	Molecular Function	Nucleotide Binding GTPase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Metal Ion Binding	Chromatin Binding RNA Binding Protein Binding Histone Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Endocytosis Cytoskeleton Organization Actin Filament Organization Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Cell Shape Rac Protein Signal Transduction Establishment Of Cell Polarity Actin Cytoskeleton Organization Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Focal Adhesion Disassembly Positive Regulation Of Protein Targeting To Mitochondrion	Chromatin Remodeling RRNA Processing RRNA Transcription
Pathways		Interleukin-4 and Interleukin-13 signaling RHOU GTPase cycle RHOU GTPase cycle
Drugs
Diseases
GWAS		Aging ( 22773346) Basal cell carcinoma ( 18849993 24403052 25855136 27539887 33549134) Chronic lymphocytic leukemia ( 28165464) Dental caries ( 23259602) Endometriosis ( 20844546) Leukoderma in response to rhododendrol ( 32558222) Mercury levels ( 26025379) Non-melanoma skin cancer ( 29739929) Response to antidepressants in depression ( 27622933) Type 2 diabetes ( 23300278)	Intelligence (MTAG) ( 29326435)
Interacting Genes		126 interacting genes: ACAD8 ADM2 ALG13 ANGPT4 ANXA4 ANXA6 AP1S1 ARHGEF25 AS3MT ATP5MG ATP6AP1 BDNF BMAL1 BNIPL BRF1 BRINP3 C14orf119 CDKL4 CFAP100 CHRNA4 CLEC7A CPNE3 CTCF CUL5 DACT2 DMRT2 DNM2 DOK4 DSCR8 EIF4B ELP5 EMC2 ERF ERO1A FAM110B FCHO2 FKBP15 GALNTL5 GLI3 GPRIN2 GRB2 H2BC14 HCAR1 HINT3 HSD17B13 ID2 IFFO1 IL17F INSM2 JAM3 KAAG1 KIAA1191 KLRC3 LANCL2 LARS2 LAYN LMO7 LYL1 ME3 MOS MRAS MRPL15 NCK1 NCR1 NPM3 NR1H2 NRBF2 NXPH4 OXCT2 P4HTM PAK1 PAK4 PCDHGA4 PDLIM3 PGK1 PIP5K1A PLCG1 PLEK PLOD3 POT1 PRB1 PRPF18 PSMA4 PXN QTRT1 RAB40A RAD51D RALBP1 RASSF1 RBIS RPL23AP5 RPS15A RPS17P16 S100A4 SEC14L4 SEMA3G SEPTIN6 SIVA1 SKIC2 SLC26A1 SNU13 SOX4 SSC4D STX16 SYK TCN2 TEKT2 TMEM106A TMEM169 TMEM255B TRIM59 USP37 UTP3 VWA5A WNT6 XPA ZFAND2B ZFP64 ZKSCAN7 ZNF117 ZNF177 ZNF20 ZNF569 ZNF625 ZNF747 ZNF84	6 interacting genes: CEP126 CRK PTEN RHOU UPRT WT1
Entrez ID		58480	10360
HPRD ID		06965	07346
Ensembl ID		ENSG00000116574	ENSG00000107833
Uniprot IDs		Q7L0Q8	O75607
PDB IDs		2Q3H
Enriched GO Terms of Interacting Partners?		Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin	Postsynaptic Specialization Assembly Postsynaptic Specialization Organization Helper T Cell Diapedesis Regulation Of Anatomical Structure Morphogenesis Cytoskeleton Organization Negative Regulation Of Wound Healing Protein Phosphorylated Amino Acid Binding Establishment Of Cell Polarity Response To Cholecystokinin Negative Regulation Of Synaptic Vesicle Clustering Regulation Of Cell-substrate Junction Organization Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Regulation Of Organ Growth Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Adrenal Cortex Formation Positive Regulation Of Metanephric Ureteric Bud Development Visceral Serous Pericardium Development Posterior Mesonephric Tubule Development Regulation Of Wound Healing Regulation Of Growth Regulation Of Cell Shape Cerebellar Neuron Development Response To Hormone Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Negative Regulation Of Female Gonad Development Negative Regulation Of Glomerular Mesangial Cell Proliferation Ribosylnicotinate Kinase Activity Ribosylnicotinamide Kinase Activity Organelle Assembly Establishment Or Maintenance Of Cell Polarity Spindle Organization Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Hemi-methylated DNA-binding Metanephric S-shaped Body Morphogenesis Regulation Of Response To Wounding Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Phosphatidylinositol Phosphate Phosphatase Activity Negative Regulation Of Cell Proliferation Involved In Kidney Development Thorax And Anterior Abdomen Determination Double-stranded Methylated DNA Binding Protein-macromolecule Adaptor Activity Diapedesis Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell-substrate Adhesion Negative Regulation Of Growth
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