SIVA1 and ABL2

Number of citations of the paper that reports this interaction (PMID 11278261)
16

Data Source:
HPRD (in vitro)

		SIVA1	ABL2
Gene Name		SIVA1, apoptosis-inducing factor	ABL proto-oncogene 2, non-receptor tyrosine kinase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion	Phagocytic Cup Cytosol Actin Cytoskeleton Lamellipodium Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Dendritic Spine
	Molecular Function	Virus Receptor Activity CD27 Receptor Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Magnesium Ion Binding Actin Monomer Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding Manganese Ion Binding Actin Filament Binding
	Biological Process	Activation-induced Cell Death Of T Cells Response To Virus Viral Process Negative Regulation Of NF-kappaB Transcription Factor Activity Extrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway	Cellular Protein Modification Process Phagocytosis Substrate-dependent Cell Migration, Cell Extension Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Axon Guidance Visual Learning Regulation Of Autophagy Positive Regulation Of Phospholipase C Activity Positive Regulation Of Neuron Projection Development Neuron Remodeling Cell Migration Peptidyl-tyrosine Phosphorylation Cerebellum Morphogenesis Negative Regulation Of Cell-cell Adhesion Regulation Of Endocytosis Regulation Of Cell Adhesion Positive Regulation Of Protein Binding Cellular Protein Localization Negative Regulation Of Rho Protein Signal Transduction Exploration Behavior Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Alpha-beta T Cell Differentiation Platelet-derived Growth Factor Receptor Signaling Pathway Dendrite Morphogenesis Neuromuscular Process Controlling Balance Actin Filament Bundle Assembly Positive Regulation Of Oxidoreductase Activity Bergmann Glial Cell Differentiation Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Retinoic Acid Dendritic Spine Maintenance Positive Regulation Of Interleukin-2 Secretion Positive Regulation Of Interferon-gamma Secretion Regulation Of Extracellular Matrix Organization Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Cell Motility Regulation Of Actin Cytoskeleton Reorganization Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways			Role of Abl in Robo-Slit signaling Axon guidance Signaling by Robo receptor
Drugs			Adenosine triphosphate Dasatinib 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE
Diseases
GWAS			IgE grass sensitization ( 22036096)
Protein-Protein Interactions		18 interactors: ABL2 APP BCL2L1 CD27 CD4 CDKN2A MEFV NEDD4 NEDD4L NGFRAP1 PCNA POLR2M PXMP2 RAD18 STMN1 TCAP TNFRSF4 UBE2D1	25 interactors: ABL1 BCR C15orf48 CAT CRK DOK1 EGFR EPHB2 ERBB2 ERBB3 ERBB4 FBXO38 GPX1 GRB2 HCK MAP3K10 NEDD4 NEDD4L OIP5 PSMA7 RIN1 SIVA1 SORBS2 TPD52L1 TRIP10
Entrez ID		10572	27
HPRD ID		16124	01259
Ensembl ID		ENSG00000184990	ENSG00000143322
Uniprot IDs		O15304	P42684
PDB IDs			2ECD 2KK1 2XYN 3GVU 3HMI 3ULR 4EIH
Enriched GO Terms of Interacting Partners?		Response To Stress Immune Response Response To Abiotic Stimulus Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Cellular Response To Stimulus Regulation Of Catalytic Activity Positive Regulation Of Proteolysis Response To Stimulus Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Peptidase Activity Regulation Of Cellular Localization Positive Regulation Of Metabolic Process Regulation Of Proteolysis Positive Regulation Of Catalytic Activity Negative Regulation Of Cellular Metabolic Process Protein Polyubiquitination Signal Transduction Regulation Of Endopeptidase Activity Immune System Process Regulation Of Peptidase Activity Intracellular Receptor Signaling Pathway Response To Radiation Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Protein Localization Signaling Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Neuron Remodeling Cell Communication Cell Surface Receptor Signaling Pathway Negative Regulation Of Sodium Ion Transport Defense Response Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Modulation By Virus Of Host Process T Cell Aggregation T Cell Activation Protein Ubiquitination Lymphocyte Aggregation Leukocyte Aggregation Interaction With Host Extrinsic Apoptotic Signaling Pathway Programmed Cell Death Regulation Of Metabolic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Hydrolase Activity Cell Death Leukocyte Cell-cell Adhesion	Regulation Of Signaling Positive Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Cell Communication Protein Autophosphorylation Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Immune Response Signaling Positive Regulation Of Protein Metabolic Process Cellular Response To Stimulus Locomotion Response To Organic Substance Immune Response-regulating Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Transferase Activity Cellular Response To Organic Substance Cellular Response To Growth Factor Stimulus Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of Cell Death Response To Growth Factor Neurotrophin Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of Protein Modification Process Peptidyl-amino Acid Modification Regulation Of Immune System Process Positive Regulation Of MAPK Cascade Cellular Protein Modification Process Regulation Of Protein Metabolic Process Phosphatidylinositol-mediated Signaling Positive Regulation Of Protein Phosphorylation Positive Regulation Of Kinase Activity Response To Stimulus Positive Regulation Of Metabolic Process Response To Stress Regulation Of Kinase Activity Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Fibroblast Growth Factor Receptor Signaling Pathway
Tagcloud ?		accelerates advance closure coexpression cutaneous dermatology doi donut downregulate electrical epidermis epithelialization es explants hdm2 healing investigative jid journal keratinocyte minute obscure phospho publication shaped stratification upregulating wound wounds	abl1 adding amenable charities crizotinib crlf2 csf1r dasatinib epor etv6 flt3 funded fusions il7r lebanese lymphoblastic ntrk3 pdgfrb ph philadelphia ptk2b rearrangements responsiveness ruxolitinib sh2b3 syrian tslp tyk2 undefined
Tagcloud (Difference) ?		accelerates advance closure coexpression cutaneous dermatology doi donut downregulate electrical epidermis epithelialization es explants hdm2 healing investigative jid journal keratinocyte minute obscure phospho publication shaped stratification upregulating wound wounds	abl1 adding amenable charities crizotinib crlf2 csf1r dasatinib epor etv6 flt3 funded fusions il7r lebanese lymphoblastic ntrk3 pdgfrb ph philadelphia ptk2b rearrangements responsiveness ruxolitinib sh2b3 syrian tslp tyk2 undefined
Tagcloud (Intersection) ?