RHOU and STX16

Number of citations of the paper that reports this interaction (PubMedID 26598620)
63

Data Source:
BioGRID (pull down)

		RHOU	STX16
Description		ras homolog family member U	syntaxin 16
Image
GO Annotations	Cellular Component	Golgi Membrane Podosome Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Endosome Membrane Membrane Cell Projection Anchoring Junction	Golgi Membrane Cytoplasm Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Cytosol Focal Adhesion Endomembrane System Membrane Synaptic Vesicle Membrane SNARE Complex Golgi Cisterna Trans-Golgi Network Membrane Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding GTPase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Metal Ion Binding	SNARE Binding SNAP Receptor Activity Protein Binding Syntaxin Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Endocytosis Cytoskeleton Organization Actin Filament Organization Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Cell Shape Rac Protein Signal Transduction Establishment Of Cell Polarity Actin Cytoskeleton Organization Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Focal Adhesion Disassembly Positive Regulation Of Protein Targeting To Mitochondrion	Intracellular Protein Transport Vesicle Fusion Protein Transport Vesicle-mediated Transport Endocytic Recycling Retrograde Transport, Endosome To Golgi Vesicle Docking
Pathways		Interleukin-4 and Interleukin-13 signaling RHOU GTPase cycle RHOU GTPase cycle	Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network
Drugs
Diseases			Pseudohypoparathyroidism
GWAS		Aging ( 22773346) Basal cell carcinoma ( 18849993 24403052 25855136 27539887 33549134) Chronic lymphocytic leukemia ( 28165464) Dental caries ( 23259602) Endometriosis ( 20844546) Leukoderma in response to rhododendrol ( 32558222) Mercury levels ( 26025379) Non-melanoma skin cancer ( 29739929) Response to antidepressants in depression ( 27622933) Type 2 diabetes ( 23300278)	Cardiovascular risk factors (age interaction) ( 20838585) Hemoglobin ( 32888494)
Interacting Genes		126 interacting genes: ACAD8 ADM2 ALG13 ANGPT4 ANXA4 ANXA6 AP1S1 ARHGEF25 AS3MT ATP5MG ATP6AP1 BDNF BMAL1 BNIPL BRF1 BRINP3 C14orf119 CDKL4 CFAP100 CHRNA4 CLEC7A CPNE3 CTCF CUL5 DACT2 DMRT2 DNM2 DOK4 DSCR8 EIF4B ELP5 EMC2 ERF ERO1A FAM110B FCHO2 FKBP15 GALNTL5 GLI3 GPRIN2 GRB2 H2BC14 HCAR1 HINT3 HSD17B13 ID2 IFFO1 IL17F INSM2 JAM3 KAAG1 KIAA1191 KLRC3 LANCL2 LARS2 LAYN LMO7 LYL1 ME3 MOS MRAS MRPL15 NCK1 NCR1 NPM3 NR1H2 NRBF2 NXPH4 OXCT2 P4HTM PAK1 PAK4 PCDHGA4 PDLIM3 PGK1 PIP5K1A PLCG1 PLEK PLOD3 POT1 PRB1 PRPF18 PSMA4 PXN QTRT1 RAB40A RAD51D RALBP1 RASSF1 RBIS RPL23AP5 RPS15A RPS17P16 S100A4 SEC14L4 SEMA3G SEPTIN6 SIVA1 SKIC2 SLC26A1 SNU13 SOX4 SSC4D STX16 SYK TCN2 TEKT2 TMEM106A TMEM169 TMEM255B TRIM59 USP37 UTP3 VWA5A WNT6 XPA ZFAND2B ZFP64 ZKSCAN7 ZNF117 ZNF177 ZNF20 ZNF569 ZNF625 ZNF747 ZNF84	12 interacting genes: MEOX2 NAPB PTPN12 RHOU STX1A STX2 STX4 STX6 VAMP3 VAMP4 VPS45 VTI1A
Entrez ID		58480	8675
HPRD ID		06965	04718
Ensembl ID		ENSG00000116574	ENSG00000124222
Uniprot IDs		Q7L0Q8	B4DJX9 O14662
PDB IDs		2Q3H	8QQF
Enriched GO Terms of Interacting Partners?		Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin	SNARE Complex SNAP Receptor Activity Organelle Fusion Vesicle-mediated Transport Vesicle Fusion Organelle Membrane Fusion SNARE Complex Assembly Vesicle Docking SNARE Binding Membrane Fusion Vesicle Organization Intracellular Protein Transport Organelle Localization By Membrane Tethering Membrane Docking Protein Transport Intracellular Transport Endomembrane System Establishment Of Protein Localization Membrane Organization Cellular Localization Establishment Of Localization In Cell Phagocytic Vesicle Intracellular Protein Localization Trans-Golgi Network Membrane Synaptic Vesicle To Endosome Fusion Vesicle-mediated Transport To The Plasma Membrane Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Cornified Envelope Assembly Endosome Exocytosis Organelle Localization Cellular Response To Type II Interferon Endocytic Recycling Clathrin-coated Vesicle Regulation Of Synaptic Vesicle Priming Localization Within Membrane Endosomal Transport Glutamatergic Synapse Golgi Vesicle Transport Retrograde Transport, Endosome To Golgi Response To Type II Interferon Post-Golgi Vesicle-mediated Transport Golgi Membrane Bounding Membrane Of Organelle Cytosolic Transport Synaptic Vesicle Organelle Organization Secretion By Cell Presynaptic Active Zone Membrane Calcium-ion Regulated Exocytosis
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