RHOU and ERF

Number of citations of the paper that reports this interaction (PubMedID 26598620)
63

Data Source:
BioGRID (pull down)

		RHOU	ERF
Description		ras homolog family member U	ETS2 repressor factor
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GO Annotations	Cellular Component	Golgi Membrane Podosome Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Endosome Membrane Membrane Cell Projection Anchoring Junction	Chromatin Nucleus Nucleoplasm Cytosol Plasma Membrane
	Molecular Function	Nucleotide Binding GTPase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Metal Ion Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Endocytosis Cytoskeleton Organization Actin Filament Organization Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Cell Shape Rac Protein Signal Transduction Establishment Of Cell Polarity Actin Cytoskeleton Organization Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Focal Adhesion Disassembly Positive Regulation Of Protein Targeting To Mitochondrion	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Differentiation
Pathways		Interleukin-4 and Interleukin-13 signaling RHOU GTPase cycle RHOU GTPase cycle	Oncogene Induced Senescence Oncogene Induced Senescence
Drugs
Diseases
GWAS		Aging ( 22773346) Basal cell carcinoma ( 18849993 24403052 25855136 27539887 33549134) Chronic lymphocytic leukemia ( 28165464) Dental caries ( 23259602) Endometriosis ( 20844546) Leukoderma in response to rhododendrol ( 32558222) Mercury levels ( 26025379) Non-melanoma skin cancer ( 29739929) Response to antidepressants in depression ( 27622933) Type 2 diabetes ( 23300278)	Meat-related diet ( 32066663) Monocyte count ( 27863252)
Interacting Genes		126 interacting genes: ACAD8 ADM2 ALG13 ANGPT4 ANXA4 ANXA6 AP1S1 ARHGEF25 AS3MT ATP5MG ATP6AP1 BDNF BMAL1 BNIPL BRF1 BRINP3 C14orf119 CDKL4 CFAP100 CHRNA4 CLEC7A CPNE3 CTCF CUL5 DACT2 DMRT2 DNM2 DOK4 DSCR8 EIF4B ELP5 EMC2 ERF ERO1A FAM110B FCHO2 FKBP15 GALNTL5 GLI3 GPRIN2 GRB2 H2BC14 HCAR1 HINT3 HSD17B13 ID2 IFFO1 IL17F INSM2 JAM3 KAAG1 KIAA1191 KLRC3 LANCL2 LARS2 LAYN LMO7 LYL1 ME3 MOS MRAS MRPL15 NCK1 NCR1 NPM3 NR1H2 NRBF2 NXPH4 OXCT2 P4HTM PAK1 PAK4 PCDHGA4 PDLIM3 PGK1 PIP5K1A PLCG1 PLEK PLOD3 POT1 PRB1 PRPF18 PSMA4 PXN QTRT1 RAB40A RAD51D RALBP1 RASSF1 RBIS RPL23AP5 RPS15A RPS17P16 S100A4 SEC14L4 SEMA3G SEPTIN6 SIVA1 SKIC2 SLC26A1 SNU13 SOX4 SSC4D STX16 SYK TCN2 TEKT2 TMEM106A TMEM169 TMEM255B TRIM59 USP37 UTP3 VWA5A WNT6 XPA ZFAND2B ZFP64 ZKSCAN7 ZNF117 ZNF177 ZNF20 ZNF569 ZNF625 ZNF747 ZNF84	10 interacting genes: CSNK1A1 EPHB2 HMGB1 MAPK1 MCRS1 MEOX2 RHOU SPOP TLE5 XPO1
Entrez ID		58480	2077
HPRD ID		06965	09942
Ensembl ID		ENSG00000116574	ENSG00000105722
Uniprot IDs		Q7L0Q8	P50548
PDB IDs		2Q3H	7JSA 7JSL
Enriched GO Terms of Interacting Partners?		Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin	Positive Regulation Of Anoikis Regulation Of Signal Transduction Response To Peptide Regulation Of Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Response To Cytokine Negative Regulation Of Wnt Signaling Pathway Regulation Of Primary Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Nuclear Speck Protein Modification Process Negative Regulation Of Cellular Component Organization Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cellular Component Organization Phosphorylation Chromosome, Centromeric Region Regulation Of Cellular Component Organization Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Kinase Activity Regulation Of Small GTPase Mediated Signal Transduction Protein Phosphorylation Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Kinase Activity Positive Regulation Of Autophagy Regulation Of Intracellular Signal Transduction Regulation Of Proteolysis Negative Regulation Of Protein-containing Complex Assembly Kinetochore Regulation Of Wound Healing Regulation Of Cellular Localization Vesicle-mediated Intercellular Transport Optic Nerve Morphogenesis Regulation Of Cell Migration Positive Regulation Of Lymphocyte Proliferation Regulation Of Locomotion Roof Of Mouth Development Hindbrain Tangential Cell Migration Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Production Neuron Projection Retraction Negative Regulation Of Glutamate Receptor Signaling Pathway Positive Regulation Of Cell Migration Postsynaptic Membrane Assembly Positive Regulation Of Cell Motility Positive Regulation Of Synaptic Transmission Positive Regulation Of Mononuclear Cell Proliferation
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