SIVA1 and POLR2M

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		SIVA1	POLR2M
Gene Name		SIVA1, apoptosis-inducing factor	polymerase (RNA) II (DNA directed) polypeptide M
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion	Nuclear Envelope DNA-directed RNA Polymerase II, Holoenzyme Neuronal Cell Body
	Molecular Function	Virus Receptor Activity CD27 Receptor Binding Protein Binding Zinc Ion Binding Metal Ion Binding	DNA-directed RNA Polymerase Activity
	Biological Process	Activation-induced Cell Death Of T Cells Response To Virus Viral Process Negative Regulation Of NF-kappaB Transcription Factor Activity Extrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway	RNA Biosynthetic Process Maintenance Of ER Location
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		18 interactors: ABL2 APP BCL2L1 CD27 CD4 CDKN2A MEFV NEDD4 NEDD4L NGFRAP1 PCNA POLR2M PXMP2 RAD18 STMN1 TCAP TNFRSF4 UBE2D1	19 interactors: AHSP ANKHD1 APOD CEBPG DGKZ HIGD1B KIAA1377 MYO3A MYO9A NEDD4 PSMC2 RBM4B RPL7A SCMH1 SIVA1 THAP1 UQCRQ WDR89 ZNF410
Entrez ID		10572	81488
HPRD ID		16124	07575
Ensembl ID		ENSG00000184990	ENSG00000255529
Uniprot IDs		O15304	P0CAP1 P0CAP2 Q6EEV4
PDB IDs			2KXS
Enriched GO Terms of Interacting Partners?		Response To Stress Immune Response Response To Abiotic Stimulus Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Cellular Response To Stimulus Regulation Of Catalytic Activity Positive Regulation Of Proteolysis Response To Stimulus Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Peptidase Activity Regulation Of Cellular Localization Positive Regulation Of Metabolic Process Regulation Of Proteolysis Positive Regulation Of Catalytic Activity Negative Regulation Of Cellular Metabolic Process Protein Polyubiquitination Signal Transduction Regulation Of Endopeptidase Activity Immune System Process Regulation Of Peptidase Activity Intracellular Receptor Signaling Pathway Response To Radiation Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Protein Localization Signaling Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Neuron Remodeling Cell Communication Cell Surface Receptor Signaling Pathway Negative Regulation Of Sodium Ion Transport Defense Response Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Modulation By Virus Of Host Process T Cell Aggregation T Cell Activation Protein Ubiquitination Lymphocyte Aggregation Leukocyte Aggregation Interaction With Host Extrinsic Apoptotic Signaling Pathway Programmed Cell Death Regulation Of Metabolic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Hydrolase Activity Cell Death Leukocyte Cell-cell Adhesion	Viral Process Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Negative Regulation Of T Cell Migration Negative Regulation Of Lipoprotein Lipid Oxidation Transmission Of Virus Development Involved In Symbiotic Interaction Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Negative Regulation Of Smooth Muscle Cell-matrix Adhesion Subthalamus Development Negative Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Lipoprotein Lipid Oxidation Mitotic DNA Damage Checkpoint Regulation Of Smooth Muscle Cell-matrix Adhesion Negative Regulation Of Monocyte Chemotactic Protein-1 Production Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint Interaction With Host Regulation Of Mitotic Cell Cycle Negative Regulation Of Lymphocyte Migration Regulation Of Intracellular Transport Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Progesterone Receptor Signaling Pathway Developmental Process
Tagcloud ?		accelerates advance closure coexpression cutaneous dermatology doi donut downregulate electrical epidermis epithelialization es explants hdm2 healing investigative jid journal keratinocyte minute obscure phospho publication shaped stratification upregulating wound wounds
Tagcloud (Difference) ?		accelerates advance closure coexpression cutaneous dermatology doi donut downregulate electrical epidermis epithelialization es explants hdm2 healing investigative jid journal keratinocyte minute obscure phospho publication shaped stratification upregulating wound wounds
Tagcloud (Intersection) ?