RHOU and BRINP3

Number of citations of the paper that reports this interaction (PubMedID 26598620)
63

Data Source:
BioGRID (pull down)

		RHOU	BRINP3
Description		ras homolog family member U	BMP/retinoic acid inducible neural specific 3
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Podosome Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Endosome Membrane Membrane Cell Projection Anchoring Junction	Extracellular Region Cytoplasm Mitochondrion Dendrite Neuronal Cell Body
	Molecular Function	Nucleotide Binding GTPase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Endocytosis Cytoskeleton Organization Actin Filament Organization Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Cell Shape Rac Protein Signal Transduction Establishment Of Cell Polarity Actin Cytoskeleton Organization Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Focal Adhesion Disassembly Positive Regulation Of Protein Targeting To Mitochondrion	Nervous System Development Central Nervous System Neuron Differentiation Social Behavior Multicellular Organism Growth Exploration Behavior Positive Regulation Of Neuron Differentiation Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Cellular Response To Retinoic Acid
Pathways		Interleukin-4 and Interleukin-13 signaling RHOU GTPase cycle RHOU GTPase cycle
Drugs
Diseases
GWAS		Aging ( 22773346) Basal cell carcinoma ( 18849993 24403052 25855136 27539887 33549134) Chronic lymphocytic leukemia ( 28165464) Dental caries ( 23259602) Endometriosis ( 20844546) Leukoderma in response to rhododendrol ( 32558222) Mercury levels ( 26025379) Non-melanoma skin cancer ( 29739929) Response to antidepressants in depression ( 27622933) Type 2 diabetes ( 23300278)	Adult body size ( 32376654) Adventurousness ( 30643258) Body mass index ( 28552196 28892062) General risk tolerance (MTAG) ( 30643258) Iron status biomarkers (total iron binding capacity) ( 28334935) Iron status biomarkers (transferrin saturation) ( 28334935) Sleep (1/2-day periodicity) ( 33075057) Sleep (1/3-day periodicity) ( 33075057) Suicide ideation score in major depressive disorder ( 26079190) Uterine fibroid size (maximum volume) ( 30196971) Zinc levels ( 26025379)
Interacting Genes		126 interacting genes: ACAD8 ADM2 ALG13 ANGPT4 ANXA4 ANXA6 AP1S1 ARHGEF25 AS3MT ATP5MG ATP6AP1 BDNF BMAL1 BNIPL BRF1 BRINP3 C14orf119 CDKL4 CFAP100 CHRNA4 CLEC7A CPNE3 CTCF CUL5 DACT2 DMRT2 DNM2 DOK4 DSCR8 EIF4B ELP5 EMC2 ERF ERO1A FAM110B FCHO2 FKBP15 GALNTL5 GLI3 GPRIN2 GRB2 H2BC14 HCAR1 HINT3 HSD17B13 ID2 IFFO1 IL17F INSM2 JAM3 KAAG1 KIAA1191 KLRC3 LANCL2 LARS2 LAYN LMO7 LYL1 ME3 MOS MRAS MRPL15 NCK1 NCR1 NPM3 NR1H2 NRBF2 NXPH4 OXCT2 P4HTM PAK1 PAK4 PCDHGA4 PDLIM3 PGK1 PIP5K1A PLCG1 PLEK PLOD3 POT1 PRB1 PRPF18 PSMA4 PXN QTRT1 RAB40A RAD51D RALBP1 RASSF1 RBIS RPL23AP5 RPS15A RPS17P16 S100A4 SEC14L4 SEMA3G SEPTIN6 SIVA1 SKIC2 SLC26A1 SNU13 SOX4 SSC4D STX16 SYK TCN2 TEKT2 TMEM106A TMEM169 TMEM255B TRIM59 USP37 UTP3 VWA5A WNT6 XPA ZFAND2B ZFP64 ZKSCAN7 ZNF117 ZNF177 ZNF20 ZNF569 ZNF625 ZNF747 ZNF84	2 interacting genes: HGS RHOU
Entrez ID		58480	339479
HPRD ID		06965	16782
Ensembl ID		ENSG00000116574	ENSG00000162670
Uniprot IDs		Q7L0Q8	Q76B58
PDB IDs		2Q3H
Enriched GO Terms of Interacting Partners?		Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin	Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway ESCRT-0 Complex Multivesicular Body Membrane Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Phagocytic Vesicle Lumen Multivesicular Body Organization Import Into Cell Regulation Of Anatomical Structure Morphogenesis Vesicle-mediated Transport Endocytosis Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Protein Targeting To Lysosome Late Endosome To Vacuole Transport Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Exosomal Secretion Endosome Transport Via Multivesicular Body Sorting Pathway Ubiquitin-like Protein Ligase Binding Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Multivesicular Body Assembly Negative Regulation Of Receptor Signaling Pathway Via STAT Positive Regulation Of Exosomal Secretion Rac Protein Signal Transduction Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Positive Regulation Of Focal Adhesion Disassembly Podosome Positive Regulation Of Protein Targeting To Mitochondrion Membrane Fission Membrane Invagination Regulation Of Protein Targeting To Mitochondrion Multivesicular Body Sorting Pathway Protein Targeting To Vacuole Protein Localization To Lysosome Establishment Of Protein Localization To Vacuole Regulation Of MAP Kinase Activity Receptor Internalization Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Exocytosis Endocytic Recycling Endosome Organization Regulation Of Cell-substrate Junction Organization Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Protein Localization To Vacuole Establishment Of Cell Polarity Ubiquitin Binding Phosphatidylinositol Binding
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?