TNNI3K and HADHB

Number of citations of the paper that reports this interaction (PMID 12721663)
9

Data Source:
HPRD (two hybrid)

		TNNI3K	HADHB
Gene Name		TNNI3 interacting kinase	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Mitochondrion Mitochondrial Envelope Mitochondrial Outer Membrane Mitochondrial Inner Membrane Endoplasmic Reticulum Mitochondrial Fatty Acid Beta-oxidation Multienzyme Complex Mitochondrial Nucleoid Extracellular Vesicular Exosome
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein C-terminus Binding Troponin I Binding Metal Ion Binding	Fatty-acyl-CoA Binding 3-hydroxyacyl-CoA Dehydrogenase Activity Acetyl-CoA C-acyltransferase Activity Enoyl-CoA Hydratase Activity Protein Binding Long-chain-enoyl-CoA Hydratase Activity Long-chain-3-hydroxyacyl-CoA Dehydrogenase Activity Protein Complex Binding Poly(A) RNA Binding NAD Binding
	Biological Process	Protein Phosphorylation	Fatty Acid Beta-oxidation Phospholipid Metabolic Process Cardiolipin Acyl-chain Remodeling Cellular Lipid Metabolic Process Small Molecule Metabolic Process Glycerophospholipid Biosynthetic Process
Pathways			Acyl chain remodeling of CL Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Mitochondrial Fatty Acid Beta-Oxidation Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA Glycerophospholipid biosynthesis Beta oxidation of hexanoyl-CoA to butanoyl-CoA Beta oxidation of palmitoyl-CoA to myristoyl-CoA Beta oxidation of octanoyl-CoA to hexanoyl-CoA Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA mitochondrial fatty acid beta-oxidation of saturated fatty acids Beta oxidation of myristoyl-CoA to lauroyl-CoA Phospholipid metabolism
Drugs
Diseases
GWAS		Body mass index ( 23669352 20935630) Obesity ( 23563607) Pubertal anthropometrics ( 23449627)
Protein-Protein Interactions		7 interactors: ACTA1 ACTC1 AIP FABP3 HADHB MYBPC3 TNNI3	12 interactors: ANXA7 APP CDKN1A CHCHD4 COX17 GRB7 RCC1 SMN1 SUOX TIMM8B TK1 TNNI3K
Entrez ID		51086	3032
HPRD ID		18208	00887
Ensembl ID		ENSG00000116783	ENSG00000138029
Uniprot IDs		Q59H18	B4E2W0 F5GZQ3 P55084
PDB IDs
Enriched GO Terms of Interacting Partners?		Actin-myosin Filament Sliding Muscle Filament Sliding Actin-mediated Cell Contraction Actin Filament-based Movement Muscle Contraction Cardiac Muscle Contraction Cardiac Muscle Tissue Morphogenesis Muscle System Process Muscle Tissue Morphogenesis Muscle Organ Development Heart Contraction Muscle Organ Morphogenesis Striated Muscle Tissue Development Myofibril Assembly Skeletal Muscle Thin Filament Assembly Muscle Tissue Development Striated Muscle Contraction Skeletal Myofibril Assembly Actomyosin Structure Organization Muscle Structure Development Striated Muscle Cell Development Muscle Cell Development Cardiac Muscle Tissue Development Actin Filament-based Process Heart Morphogenesis Striated Muscle Cell Differentiation Regulation Of ATPase Activity Ventricular Cardiac Muscle Tissue Morphogenesis Blood Circulation Muscle Cell Differentiation Ventricular Cardiac Muscle Tissue Development Cardiac Ventricle Morphogenesis Organelle Assembly Heart Development Cardiac Ventricle Development Movement Of Cell Or Subcellular Component Actin Cytoskeleton Organization Skeletal Muscle Fiber Adaptation Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Tissue Morphogenesis Cardiac Chamber Development Tissue Development Regulation Of Muscle Contraction Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of Muscle Filament Sliding Myosin Filament Assembly Cardiovascular System Development Positive Regulation Of Phospholipid Biosynthetic Process Cardiolipin Acyl-chain Remodeling Long-chain Fatty Acid Import	Protein Targeting To Mitochondrion Protein Import Into Mitochondrial Intermembrane Space Fetal Process Involved In Parturition Protein Localization To Mitochondrion Regulation Of Mitotic Cell Cycle Skeletal Muscle Cell Proliferation Synaptic Growth At Neuromuscular Junction Hemostasis Collateral Sprouting In Absence Of Injury Cellular Component Assembly Regulation Of Cell Cycle Process Digestive Tract Development Collateral Sprouting Axon Midline Choice Point Recognition Sulfide Oxidation, Using Sulfide:quinone Oxidoreductase Intestinal Epithelial Cell Maturation Cell Maturation Digestive System Development Regulation Of Body Fluid Levels Mitochondrial Transport Response To Glucocorticoid G1/S Transition Of Mitotic Cell Cycle Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Response To Cortisol Thymidine Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Corticosteroid Ribonucleoprotein Complex Assembly Axon Choice Point Recognition Response To Toxic Substance Cellular Response To UV-B Chaperone-mediated Protein Transport Deoxyribonucleoside Monophosphate Biosynthetic Process Positive Regulation Of Ran GTPase Activity Neuron Remodeling Pyrimidine Nucleoside Salvage Pyrimidine-containing Compound Salvage Cellular Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Stress-induced Premature Senescence Protein Maturation By Protein Folding Regulation Of Cell Cycle Phase Transition
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