TNNI3K and ACTA1

Number of citations of the paper that reports this interaction (PubMedID 12721663)
0

Data Source:
HPRD (two hybrid)

		TNNI3K	ACTA1
Description		TNNI3 interacting kinase	actin alpha 1, skeletal muscle
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm	Stress Fiber Extracellular Space Cytoplasm Cytosol Cytoskeleton Striated Muscle Thin Filament Actin Filament Actin Cytoskeleton Sarcomere Lamellipodium Filopodium Cell Body Extracellular Exosome Blood Microparticle
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	Nucleotide Binding Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Hydrolase Activity Myosin Binding ADP Binding
	Biological Process	Regulation Of Heart Rate Protein Phosphorylation Peptidyl-serine Autophosphorylation Regulation Of Cardiac Muscle Contraction Bundle Of His Cell To Purkinje Myocyte Communication Regulation Of Cardiac Conduction	Muscle Contraction Positive Regulation Of Gene Expression Skeletal Muscle Thin Filament Assembly Skeletal Muscle Fiber Development Mesenchyme Migration
Pathways			Striated Muscle Contraction Regulation of CDH1 Function Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Drugs		Fostamatinib	Latrunculin A Sucrose Ulapualide A Kabiramide C Jaspisamide A Tmr 1-Methylhistidine Phosphoaminophosphonic Acid-Adenylate Ester Aplyronine A Reidispongiolide A Reidispongiolide C Sphinxolide B Latrunculin B
Diseases			Cap myopathy Congenital fiber type disproportion (CFTD) Nemaline myopathy
GWAS		Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 23669352 28892062 26426971 28448500 20935630) Body mass index (age <50) ( 26426971) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Body size at age 10 ( 32376654) Childhood body mass index ( 26604143 33045005) Hip circumference ( 25673412) Menarche (age at onset) ( 27182965 25231870) Mental health study participation (completed survey) ( 31263887) Obesity ( 23563607) Parental longevity (combined parental age at death) ( 29227965) Pubertal anthropometrics ( 23449627) Smoking initiation ( 30617275 33082346) Smoking initiation (ever regular vs never regular) ( 30679032)
Interacting Genes		8 interacting genes: ACTA1 ACTC1 AIP FABP3 FBXO4 HADHB MYBPC3 TNNI3	115 interacting genes: ABL1 ABRA ACTR10 ACTR1B ADSS2 AFAP1 AIF1 AJUBA AMOT ANXA2 BIN1 CCIN CCT2 CCT4 CCT5 CFL1 CLIC5 CNN1 CORO2B COTL1 CTNND1 CTTN CYFIP1 CYTH1 DHX9 DLG1 DMD DNASE1 DNMBP DTNA DUX4L9 EGFR EPB41 EPB41L2 EPS8 FGD4 FHOD1 FSCN1 GAS2 GAS7 GC GSN HCLS1 HDAC4 HIP1R HSPB2 HTRA2 IQGAP1 ITGA2 ITPKA KIF23 KLHL20 LASP1 LINC00624 MACF1 MAP1A MAPT MIB2 MINPP1 MYL1 MYLK MYO10 MYO6 MYO7A MYO9B NEXN NR3C2 NRAP PAK1 PARVA PCYT1B PFDN1 PFN1 PHACTR1 PLD1 PPP1R9B PRKCA PRKCD PRKCE RAC1 RNF167 RPS6KB1 S100A1 S100A4 SCIN SMTN SNCA SORBS1 SPRR1A SPTA1 SPTAN1 SPTBN2 TAGLN TJP1 TLN1 TMSB4X TMSB4Y TNNI1 TNNI3 TNNI3K TP53 TPM2 TPM3 TRIM55 TRIM63 TTN UBC USP25 USP6NL UTRN VASP VAV1 VCL VIL1 XIRP1
Entrez ID		51086	58
HPRD ID		18208	00030
Ensembl ID		ENSG00000116783	ENSG00000143632
Uniprot IDs		Q59H18	P68133
PDB IDs		4YFF 4YFI 6B5J 7MGJ 7MGK	7RNS 7RNU 7RNV 9DUU 9DUV
Enriched GO Terms of Interacting Partners?		Sarcomere Myosin Binding Cardiac Muscle Contraction Muscle Contraction Mesenchyme Migration Cardiac Muscle Tissue Morphogenesis Muscle System Process Skeletal Muscle Thin Filament Assembly Muscle Tissue Morphogenesis Cardiac Myofibril Striated Muscle Contraction Actin-myosin Filament Sliding Heart Contraction Heart Process Actin-mediated Cell Contraction Ventricular Cardiac Muscle Tissue Morphogenesis Actin Filament-based Movement Icosatetraenoic Acid Binding C Zone Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions GAF Domain Binding Filopodium Cell Body Regulation Of Cardiac Muscle Contraction Actin Filament Actin Filament-based Process Tissue Morphogenesis Oleic Acid Binding Regulation Of Striated Muscle Contraction Blood Microparticle Actomyosin Structure Organization Positive Regulation Of Long-chain Fatty Acid Import Into Cell Acetyl-CoA C-myristoyltransferase Activity Mitochondrial Fatty Acid Beta-oxidation Multienzyme Complex Regulation Of Muscle Filament Sliding Striated Muscle Myosin Thick Filament Cardiac Troponin Complex Troponin C Binding Cytosol Acetyl-CoA C-acyltransferase Activity Troponin T Binding Cytoplasmic Actin-based Contraction Involved In Cell Motility Long-chain Fatty Acid Binding Regulation Of Phosphatidylcholine Biosynthetic Process System Process Acetyl-CoA C-acetyltransferase Activity (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Regulation Of Muscle Contraction Lamellipodium Enoyl-CoA Hydratase Activity	Actin Binding Actin Filament Binding Cytoskeleton Actin Cytoskeleton Actin Filament-based Process Cytoplasm Actin Filament Organization Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament Organization Actin Cytoskeleton Organization Supramolecular Fiber Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Length Regulation Of Cytoskeleton Organization Regulation Of Actin Filament-based Process Cytosol Regulation Of Cellular Component Size Regulation Of Protein-containing Complex Assembly Cell Cortex Cytoskeleton Organization Regulation Of Organelle Organization Regulation Of Cellular Component Organization Focal Adhesion Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Organelle Organization Positive Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Lamellipodium Ruffle Actin Filament Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Cellular Component Organization Positive Regulation Of Protein Localization Cortical Actin Cytoskeleton Positive Regulation Of Cellular Component Biogenesis Actin Polymerization Or Depolymerization Regulation Of Biological Quality Anchoring Junction Organelle Organization Ruffle Membrane Positive Regulation Of Protein-containing Complex Assembly Cell Projection Filopodium Regulation Of Cell Shape Muscle System Process Negative Regulation Of Actin Filament Depolymerization Regulation Of Protein Localization
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?