TNNI3K and MYBPC3

Number of citations of the paper that reports this interaction (PMID 12721663)
9

Data Source:
HPRD (two hybrid)

		TNNI3K	MYBPC3
Gene Name		TNNI3 interacting kinase	myosin binding protein C, cardiac
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Cytosol Striated Muscle Myosin Thick Filament C Zone Sarcomere A Band
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein C-terminus Binding Troponin I Binding Metal Ion Binding	ATPase Activator Activity Actin Binding Structural Constituent Of Muscle Myosin Binding Titin Binding Myosin Heavy Chain Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Protein Phosphorylation	Regulation Of Heart Rate Heart Morphogenesis Regulation Of Striated Muscle Contraction Cell Adhesion Muscle Filament Sliding Myosin Filament Assembly Positive Regulation Of ATPase Activity Regulation Of Muscle Filament Sliding Sarcomere Organization Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction
Pathways			Striated Muscle Contraction
Drugs
Diseases
GWAS		Body mass index ( 23669352 20935630) Obesity ( 23563607) Pubertal anthropometrics ( 23449627)
Protein-Protein Interactions		7 interactors: ACTA1 ACTC1 AIP FABP3 HADHB MYBPC3 TNNI3	7 interactors: CAPN1 MYH9 NCF1 TNNI3K TRIM55 TRIM63 TTN
Entrez ID		51086	4607
HPRD ID		18208	02980
Ensembl ID		ENSG00000116783	ENSG00000134571
Uniprot IDs		Q59H18	A5YM48 Q14896
PDB IDs			1GXE 1PD6 2AVG 2K1M 2V6H 3CX2
Enriched GO Terms of Interacting Partners?		Actin-myosin Filament Sliding Muscle Filament Sliding Actin-mediated Cell Contraction Actin Filament-based Movement Muscle Contraction Cardiac Muscle Contraction Cardiac Muscle Tissue Morphogenesis Muscle System Process Muscle Tissue Morphogenesis Muscle Organ Development Heart Contraction Muscle Organ Morphogenesis Striated Muscle Tissue Development Myofibril Assembly Skeletal Muscle Thin Filament Assembly Muscle Tissue Development Striated Muscle Contraction Skeletal Myofibril Assembly Actomyosin Structure Organization Muscle Structure Development Striated Muscle Cell Development Muscle Cell Development Cardiac Muscle Tissue Development Actin Filament-based Process Heart Morphogenesis Striated Muscle Cell Differentiation Regulation Of ATPase Activity Ventricular Cardiac Muscle Tissue Morphogenesis Blood Circulation Muscle Cell Differentiation Ventricular Cardiac Muscle Tissue Development Cardiac Ventricle Morphogenesis Organelle Assembly Heart Development Cardiac Ventricle Development Movement Of Cell Or Subcellular Component Actin Cytoskeleton Organization Skeletal Muscle Fiber Adaptation Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Tissue Morphogenesis Cardiac Chamber Development Tissue Development Regulation Of Muscle Contraction Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of Muscle Filament Sliding Myosin Filament Assembly Cardiovascular System Development Positive Regulation Of Phospholipid Biosynthetic Process Cardiolipin Acyl-chain Remodeling Long-chain Fatty Acid Import	Actin Filament-based Movement Actomyosin Structure Organization Neutrophil Mediated Killing Of Gram-positive Bacterium Neutrophil Mediated Killing Of Fungus Sarcomerogenesis Detection Of Muscle Stretch Skeletal Muscle Myosin Thick Filament Assembly Directional Locomotion Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Platelet Activation Uropod Organization Establishment Of Meiotic Spindle Localization Myosin Filament Assembly Establishment Of T Cell Polarity Respiratory Burst Involved In Defense Response Skeletal Muscle Atrophy Response To Yeast Muscle Contraction Striated Muscle Cell Differentiation Skeletal Muscle Thin Filament Assembly Striated Muscle Atrophy Muscle Atrophy Killing By Host Of Symbiont Cells Cardiac Muscle Fiber Development Response To Muscle Stretch Skeletal Myofibril Assembly Muscle System Process Skeletal Muscle Adaptation Hydrogen Peroxide Biosynthetic Process Meiotic Spindle Organization Muscle Cell Differentiation Respiratory Burst Receptor Catabolic Process Negative Regulation Of Smooth Muscle Contraction Adult Heart Development Superoxide Anion Generation Monocyte Differentiation Membrane Protein Ectodomain Proteolysis Myoblast Fusion Neutrophil Mediated Immunity Blood Coagulation Hemostasis Negative Regulation Of Muscle Contraction Platelet Formation Platelet Morphogenesis Cardiac Myofibril Assembly Killing Of Cells Of Other Organism Proteolysis Cardiac Muscle Hypertrophy Mitotic Chromosome Condensation
Tagcloud ?			11p11 28x10 38x 73x10 a1 acp2 allele attenuate chr11 encompassing epidemiology fasting fi forkhead foxa1 hepatoma hg18 influencing intron jointly kernel lies madd nr1h3 rare rs10838687 rs7944584 spi1 variants
Tagcloud (Difference) ?			11p11 28x10 38x 73x10 a1 acp2 allele attenuate chr11 encompassing epidemiology fasting fi forkhead foxa1 hepatoma hg18 influencing intron jointly kernel lies madd nr1h3 rare rs10838687 rs7944584 spi1 variants
Tagcloud (Intersection) ?