MYO7A and CDH23

Number of citations of the paper that reports this interaction (PubMedID 12485990)
44

Data Source:
HPRD (in vitro)

		MYO7A	CDH23
Description		myosin VIIA	cadherin related 23
Image
GO Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Cytoplasm Lysosomal Membrane Cytosol Cytoskeleton Microvillus Cell Cortex Actin Cytoskeleton Membrane Apical Plasma Membrane Myosin Complex Myosin VII Complex Photoreceptor Connecting Cilium Stereocilium Melanosome Synapse Photoreceptor Cell Cilium Stereocilium Base Upper Tip-link Density	Photoreceptor Inner Segment Centrosome Plasma Membrane Membrane Catenin Complex Stereocilium Stereocilium Tip Synapse Kinocilium Cochlear Hair Cell Ribbon Synapse Photoreceptor Ribbon Synapse
	Molecular Function	Microfilament Motor Activity Nucleotide Binding Cytoskeletal Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding Protein Domain Specific Binding Spectrin Binding Identical Protein Binding ADP Binding Protein-containing Complex Binding Actin Filament Binding	Calcium Ion Binding Protein Binding Beta-catenin Binding Cadherin Binding Metal Ion Binding
	Biological Process	Phagolysosome Assembly Intracellular Protein Transport Endocytosis Phagocytosis Actin Filament Organization Lysosome Organization Sensory Organ Development Sensory Perception Visual Perception Sensory Perception Of Sound Intracellular Protein Localization Cell Projection Organization Actin Filament-based Movement Eye Photoreceptor Cell Development Inner Ear Morphogenesis Mechanoreceptor Differentiation Inner Ear Auditory Receptor Cell Differentiation Neuron Development Inner Ear Development Sensory Perception Of Light Stimulus Equilibrioception Pigment Granule Localization Pigment Granule Transport Auditory Receptor Cell Stereocilium Organization Inner Ear Receptor Cell Differentiation Inner Ear Receptor Cell Stereocilium Organization Cochlea Development Sensory Organ Morphogenesis	Calcium Ion Transport Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Visual Perception Sensory Perception Of Sound Locomotory Behavior Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Migration Neuron Projection Development Inner Ear Morphogenesis Inner Ear Auditory Receptor Cell Differentiation Photoreceptor Cell Maintenance Inner Ear Development Sensory Perception Of Light Stimulus Equilibrioception Regulation Of Cytosolic Calcium Ion Concentration Auditory Receptor Cell Stereocilium Organization Inner Ear Receptor Cell Stereocilium Organization Cochlea Development Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules
Pathways		The canonical retinoid cycle in rods (twilight vision) Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea	Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Drugs
Diseases		Deafness, autosomal recessive Usher syndrome (US) Deafness, autosomal dominant	Deafness, autosomal recessive Usher syndrome (US)
GWAS		Lewy body disease ( 25188341) Post bronchodilator FEV1/FVC ratio ( 26634245) Tourette syndrome ( 30818990)	Age at smoking initiation in chronic obstructive pulmonary disease ( 21685187) Age-related hearing impairment ( 34108613) Bipolar disorder (body mass index interaction) ( 24322204) Cerebrospinal fluid beta-site APP cleaving enzyme levels ( 29751835) Cognitive performance (processing speed) ( 31598132) Decline in glucose metabolism in posterior cingulate cortex ( 29130521) Diffusing capacity of the lung for carbon monoxide traits ( 30049742) Diisocyanate-induced asthma ( 25918132) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Kidney function decline traits ( 25493955) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 32888494) Progranulin levels ( 29186428) Selective IgA deficiency ( 27723758) Self-reported risk-taking behaviour ( 30271922) Systemic lupus erythematosus ( 33272962 33536424) Vitiligo ( 22951725)
Interacting Genes		12 interacting genes: ACTA1 CALM1 CDH23 KEAP1 KHDRBS1 LINC00839 MAP2 MYRIP PRKAR1A USH1C VEZT WHRN	3 interacting genes: CLK1 MYO7A USH1C
Entrez ID		4647	64072
HPRD ID		02043	05699
Ensembl ID		ENSG00000137474	ENSG00000107736
Uniprot IDs		Q13402	A0A087WYR8 A5D6V9 Q6P152 Q8N5B3 Q9H251
PDB IDs		5MV9	2KBR 2KBS 2LSR 5TFM 5VVM 5WJ8
Enriched GO Terms of Interacting Partners?		Stereocilia Ankle Link Complex Stereocilium Tip Inner Ear Receptor Cell Differentiation Myosin Binding Mechanoreceptor Differentiation Inner Ear Receptor Cell Stereocilium Organization Stereocilium Equilibrioception Cell Cycle Phase Transition G2/M Transition Of Mitotic Cell Cycle Cell Cycle G2/M Phase Transition Photoreceptor Inner Segment Actin Filament Auditory Receptor Cell Stereocilium Organization Inner Ear Auditory Receptor Cell Differentiation Hair Cell Differentiation Mitotic Cell Cycle Phase Transition Sensory Perception Of Mechanical Stimulus Sensory Perception Of Sound Cytosol Neuron Projection Development Photoreceptor Cell Maintenance Sensory Perception Of Light Stimulus Synapse Apical Distal Dendrite Pyruvate Carboxylase Activity Grb2-Sos Complex Sarcomere Negative Regulation Of High Voltage-gated Calcium Channel Activity Centrosome Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cilium Dendritic Filopodium Positive Regulation Of Anterograde Synaptic Vesicle Transport Distal Dendrite Positive Regulation Of Anterograde Dense Core Granule Transport Primary Dendrite Viral RNA Genome Packaging Protein Localization To Microvillus Inner Ear Morphogenesis Photoreceptor Outer Segment Cerebellar Purkinje Cell Layer Formation Paranodal Junction Maintenance Cochlear Hair Cell Ribbon Synapse Cell Cycle G1/S Phase Transition Cell Projection Proximal Neuron Projection Dendritic Branch Positive Regulation Of Insulin Secretion Stereocilia Ankle Link	Equilibrioception Inner Ear Auditory Receptor Cell Differentiation Hair Cell Differentiation Spectrin Binding Inner Ear Receptor Cell Differentiation Mechanoreceptor Differentiation Eye Photoreceptor Cell Development Inner Ear Receptor Cell Stereocilium Organization Photoreceptor Cell Development Stereocilium Photoreceptor Inner Segment Inner Ear Morphogenesis Microvillus Photoreceptor Outer Segment Epidermal Cell Differentiation Upper Tip-link Density Myosin VII Complex Sensory Perception Of Sound Sensory Perception Of Mechanical Stimulus Neuron Development Protein Localization To Microvillus Sensory Perception Of Light Stimulus Phagolysosome Assembly Stereocilium Base Actin Filament Organization Brush Border Assembly Regulation Of Microvillus Length Stereocilia Ankle Link Complex Auditory Receptor Cell Morphogenesis Parallel Actin Filament Bundle Assembly Neuron Differentiation Photoreceptor Cell Cilium Epithelial Cell Differentiation Embryonic Morphogenesis Retinal Cone Cell Development Regulation Of Cell Projection Size Sensory Perception Neuron Projection Development Supramolecular Fiber Organization Stereocilium Tip Auditory Receptor Cell Stereocilium Organization Cell Morphogenesis Involved In Neuron Differentiation Pigment Granule Transport Pigment Granule Localization Protein Serine/threonine/tyrosine Kinase Activity Microfilament Motor Activity Cochlea Development ADP Binding Non-membrane Spanning Protein Tyrosine Kinase Activity Photoreceptor Connecting Cilium
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