MYO7A and PRKAR1A

Number of citations of the paper that reports this interaction (PMID 10889203)
9

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (two hybrid, in vivo)

		MYO7A	PRKAR1A
Gene Name		myosin VIIA	protein kinase, cAMP-dependent, regulatory, type I, alpha
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Cytoplasm Lysosomal Membrane Cytosol Cell Cortex Apical Plasma Membrane Myosin VII Complex Photoreceptor Connecting Cilium Stereocilium Melanosome Synapse	Cytosol Plasma Membrane CAMP-dependent Protein Kinase Complex Membrane AMP-activated Protein Kinase Complex Neuromuscular Junction Protein Complex Ciliary Base
	Molecular Function	Microfilament Motor Activity Protein Binding Calmodulin Binding ATP Binding Protein Domain Specific Binding Spectrin Binding Actin-dependent ATPase Activity Protein Homodimerization Activity ADP Binding Actin Filament Binding	CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding
	Biological Process	Phagolysosome Assembly Intracellular Protein Transport Lysosome Organization Visual Perception Sensory Perception Of Sound Actin Filament-based Movement Eye Photoreceptor Cell Development Post-embryonic Organ Morphogenesis Sensory Perception Of Light Stimulus Equilibrioception Pigment Granule Transport Auditory Receptor Cell Stereocilium Organization	Mesoderm Formation Renal Water Homeostasis Energy Reserve Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Water Transport Female Meiotic Division Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Activation Of Protein Kinase A Activity Intracellular Signal Transduction Small Molecule Metabolic Process Innate Immune Response Sarcomere Organization Negative Regulation Of Meiotic Nuclear Division Neurotrophin TRK Receptor Signaling Pathway Regulation Of Insulin Secretion Transmembrane Transport Cardiac Muscle Cell Proliferation Cellular Response To Glucagon Stimulus Negative Regulation Of CAMP-dependent Protein Kinase Activity
Pathways		Visual phototransduction The canonical retinoid cycle in rods (twilight vision) Diseases associated with visual transduction	Signaling by GPCR Ca-dependent events CaM pathway Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Hedgehog 'off' state Integration of energy metabolism Phospholipase C-mediated cascade Signaling by FGFR in disease Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling DAG and IP3 signaling CaM pathway DAP12 signaling Downstream signaling of activated FGFR DARPP-32 events Glucagon signaling in metabolic regulation Innate Immune System Signaling by PDGF PKA activation in glucagon signalling Calmodulin induced events Signalling by NGF DAP12 interactions PKA-mediated phosphorylation of CREB PLC beta mediated events Vasopressin regulates renal water homeostasis via Aquaporins Opioid Signalling Regulation of insulin secretion Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane G-protein mediated events PKA activation Factors involved in megakaryocyte development and platelet production Signaling by Overexpressed Wild-Type EGFR in Cancer Aquaporin-mediated transport Signaling by FGFR EGFR interacts with phospholipase C-gamma Signaling by ERBB2 PKA-mediated phosphorylation of CREB Signaling by EGFR Downstream signal transduction Calmodulin induced events Signaling by Hedgehog PLC-gamma1 signalling Signaling by EGFR in Cancer PKA activation
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: ACTA1 CALM1 CDH23 DFNB31 KEAP1 KHDRBS1 MAP2 MYRIP PRKAR1A USH1C VEZT	40 interactors: AKAP1 AKAP10 AKAP11 AKAP4 AKAP7 ARFGEF2 BAHD1 C2orf44 C2orf88 CAPN11 CBS CCNE1 CDK2 CDK4 EGFR GRB2 HIVEP1 HLA-A ITGA4 MAPK6 MAPT MYO7A NELL2 PATZ1 PJA2 PLEKHF2 PRKACA PRKAR1B PRKX PRPF40A PYCARD RAF1 RFC2 SET SETD7 SLC2A4 SMAD2 TAB1 WNK1 ZBED1
Entrez ID		4647	5573
HPRD ID		02043	01786
Ensembl ID		ENSG00000137474	ENSG00000108946
Uniprot IDs		B9A012 Q13402	B2R5T5 K7ER48 P10644 Q68DQ4
PDB IDs
Enriched GO Terms of Interacting Partners?		Retina Homeostasis Equilibrioception Sensory Perception Of Sound Sensory Perception Of Light Stimulus Sensory Perception Of Mechanical Stimulus Tissue Homeostasis Photoreceptor Cell Maintenance Multicellular Organismal Homeostasis Multicellular Organismal Development Activation Of Phospholipase C Activity Anatomical Structure Development Positive Regulation Of Phospholipase C Activity Inner Ear Receptor Cell Differentiation Mechanoreceptor Differentiation Myofibril Assembly Positive Regulation Of Phospholipase Activity Neuromuscular Process Controlling Balance Developmental Process Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Regulation Of Cellular Localization Positive Regulation Of RNA Export From Nucleus Skeletal Muscle Fiber Adaptation Parallel Actin Filament Bundle Assembly Actomyosin Structure Organization Positive Regulation Of Cellular Protein Metabolic Process Cytoskeleton Organization Embryo Development G2/M Transition Of Mitotic Cell Cycle Neuromuscular Process Positive Regulation Of Protein Metabolic Process Energy Reserve Metabolic Process Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Proteasomal Ubiquitin-independent Protein Catabolic Process Striated Muscle Cell Development Regulation Of High Voltage-gated Calcium Channel Activity Actin Cytoskeleton Organization Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Muscle Cell Development Fibroblast Growth Factor Receptor Signaling Pathway Homeostatic Process Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Actin Filament-based Process Skeletal Muscle Thin Filament Assembly Inner Ear Development Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Response To Organic Substance Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity	Blood Coagulation Hemostasis Regulation Of Protein Kinase Activity Regulation Of Protein Kinase A Signaling Regulation Of Body Fluid Levels Regulation Of Kinase Activity Intracellular Signal Transduction Wound Healing Protein Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Organonitrogen Compound Response To Wounding Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Movement Of Cell Or Subcellular Component Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Phosphorylation Innate Immune Response Cellular Response To Growth Factor Stimulus Cellular Response To Stimulus Regulation Of Protein Phosphorylation Response To Stress Response To Growth Factor Signal Transduction Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Enzyme Linked Receptor Protein Signaling Pathway Activation Of Protein Kinase Activity Activation Of Phospholipase C Activity Cell Motility Regulation Of Phosphorus Metabolic Process Cell Activation Positive Regulation Of Phospholipase C Activity Cellular Response To Organic Substance G1/S Transition Of Mitotic Cell Cycle Signaling Locomotion Cellular Response To Peptide Hormone Stimulus Mitotic Cell Cycle Cell Communication Cellular Response To Peptide Regulation Of Cellular Protein Metabolic Process Cell Cycle Regulation Of Catalytic Activity Positive Regulation Of Phospholipase Activity Heterochromatin Organization
Tagcloud ?		11q13 15q21 1e aas admixture african americans ancestry caucasian causation chr15q21 cytoskeleton dermal descent exome genotyping gwas japanese keloid keloids mapping migratory myo1e myosin nedd4 peaks predisposition rs35641839 sporadically	agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1
Tagcloud (Difference) ?		11q13 15q21 1e aas admixture african americans ancestry caucasian causation chr15q21 cytoskeleton dermal descent exome genotyping gwas japanese keloid keloids mapping migratory myo1e myosin nedd4 peaks predisposition rs35641839 sporadically	agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1
Tagcloud (Intersection) ?