MYO7A and MAP2

Number of citations of the paper that reports this interaction (PubMedID 11171103)
35

Data Source:
HPRD (in vivo)

		MYO7A	MAP2
Description		myosin VIIA	microtubule associated protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Cytoplasm Lysosomal Membrane Cytosol Cytoskeleton Microvillus Cell Cortex Actin Cytoskeleton Membrane Apical Plasma Membrane Myosin Complex Myosin VII Complex Photoreceptor Connecting Cilium Stereocilium Melanosome Synapse Photoreceptor Cell Cilium Stereocilium Base Upper Tip-link Density	Cytoplasm Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Plasma Membrane Cilium Dendrite Dendrite Cytoplasm Cell Projection Neuron Projection Neuronal Cell Body Axon Initial Segment Dendritic Shaft Axon Hillock Dendritic Growth Cone Main Axon Dendritic Branch Basal Dendrite Primary Dendrite Distal Dendrite Apical Distal Dendrite Dendritic Filopodium Proximal Dendrite Proximal Neuron Projection
	Molecular Function	Microfilament Motor Activity Nucleotide Binding Cytoskeletal Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding Protein Domain Specific Binding Spectrin Binding Identical Protein Binding ADP Binding Protein-containing Complex Binding Actin Filament Binding	Dystroglycan Binding Structural Molecule Activity Protein Binding Calmodulin Binding Microtubule Binding Tubulin Binding Tau Protein Binding
	Biological Process	Phagolysosome Assembly Intracellular Protein Transport Endocytosis Phagocytosis Actin Filament Organization Lysosome Organization Sensory Organ Development Sensory Perception Visual Perception Sensory Perception Of Sound Intracellular Protein Localization Cell Projection Organization Actin Filament-based Movement Eye Photoreceptor Cell Development Inner Ear Morphogenesis Mechanoreceptor Differentiation Inner Ear Auditory Receptor Cell Differentiation Neuron Development Inner Ear Development Sensory Perception Of Light Stimulus Equilibrioception Pigment Granule Localization Pigment Granule Transport Auditory Receptor Cell Stereocilium Organization Inner Ear Receptor Cell Differentiation Inner Ear Receptor Cell Stereocilium Organization Cochlea Development Sensory Organ Morphogenesis	Microtubule Cytoskeleton Organization Dendrite Development Central Nervous System Neuron Development Negative Regulation Of Axon Extension Regulation Of Microtubule Polymerization Negative Regulation Of Microtubule Polymerization Neuron Projection Development Regulation Of Protein Localization Dendrite Morphogenesis Positive Regulation Of Anterograde Dense Core Granule Transport Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Anterograde Synaptic Vesicle Transport
Pathways		The canonical retinoid cycle in rods (twilight vision) Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Drugs			Estramustine Paclitaxel Docetaxel
Diseases		Deafness, autosomal recessive Usher syndrome (US) Deafness, autosomal dominant
GWAS		Lewy body disease ( 25188341) Post bronchodilator FEV1/FVC ratio ( 26634245) Tourette syndrome ( 30818990)	Adventurousness ( 30643258) Bipolar disorder ( 31043756) Body mass index ( 28552196) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) General risk tolerance (MTAG) ( 30643258) Handedness (Left-handed vs. non-left-handed) ( 30980028 31504236) Handedness (left-handed vs. right-handed) ( 31504236) Height ( 28552196) LDL cholesterol levels in HIV infection ( 33109212) Left-handedness ( 32989287) Left–right brain asymmetry ( 33723403) Skin and soft tissue infections ( 33662382) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		12 interacting genes: ACTA1 CALM1 CDH23 KEAP1 KHDRBS1 LINC00839 MAP2 MYRIP PRKAR1A USH1C VEZT WHRN	26 interacting genes: ACTB ACTN1 APOE APP CPEB1 DAG1 FYN GRB2 GRIN1 GRIN2D ITCH JUNB MARK1 MARK3 MARK4 MDM2 MYO7A NEDD4L NEFL PAFAH1B1 PLEC PRKACA PRKAR2A SRC TTBK1 YAP1
Entrez ID		4647	4133
HPRD ID		02043	01140
Ensembl ID		ENSG00000137474	ENSG00000078018
Uniprot IDs		Q13402	A0A024R3Z1 P11137 Q6NYC5
PDB IDs		5MV9
Enriched GO Terms of Interacting Partners?		Stereocilia Ankle Link Complex Stereocilium Tip Inner Ear Receptor Cell Differentiation Myosin Binding Mechanoreceptor Differentiation Inner Ear Receptor Cell Stereocilium Organization Stereocilium Equilibrioception Cell Cycle Phase Transition G2/M Transition Of Mitotic Cell Cycle Cell Cycle G2/M Phase Transition Photoreceptor Inner Segment Actin Filament Auditory Receptor Cell Stereocilium Organization Inner Ear Auditory Receptor Cell Differentiation Hair Cell Differentiation Mitotic Cell Cycle Phase Transition Sensory Perception Of Mechanical Stimulus Sensory Perception Of Sound Cytosol Neuron Projection Development Photoreceptor Cell Maintenance Sensory Perception Of Light Stimulus Synapse Apical Distal Dendrite Pyruvate Carboxylase Activity Grb2-Sos Complex Sarcomere Negative Regulation Of High Voltage-gated Calcium Channel Activity Centrosome Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cilium Dendritic Filopodium Positive Regulation Of Anterograde Synaptic Vesicle Transport Distal Dendrite Positive Regulation Of Anterograde Dense Core Granule Transport Primary Dendrite Viral RNA Genome Packaging Protein Localization To Microvillus Inner Ear Morphogenesis Photoreceptor Outer Segment Cerebellar Purkinje Cell Layer Formation Paranodal Junction Maintenance Cochlear Hair Cell Ribbon Synapse Cell Cycle G1/S Phase Transition Cell Projection Proximal Neuron Projection Dendritic Branch Positive Regulation Of Insulin Secretion Stereocilia Ankle Link	Tau Protein Binding Intracellular Signal Transduction Cellular Response To Oxygen-containing Compound Tau-protein Kinase Activity Regulation Of Protein Localization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Modulation Of Chemical Synaptic Transmission Protein Domain Specific Binding Anatomical Structure Morphogenesis Glutamatergic Synapse Regulation Of Cellular Component Organization Cytoskeleton Organization Regulation Of Synapse Organization Positive Regulation Of Protein Localization Regulation Of Multicellular Organismal Process Dendrite Phospholipase Binding Developmental Process Supramolecular Fiber Organization Regulation Of Developmental Process System Process Ephrin Receptor Binding Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Developmental Process Response To Hormone Cytoplasm Plasma Membrane Regulation Of Cell Activation Response To Peptide Hormone Regulation Of Endocytosis Positive Regulation Of Cellular Component Organization Nervous System Process Cellular Component Assembly Negative Regulation Of Signal Transduction Extracellular Exosome Cell-cell Junction Regulation Of Cellular Localization Cytosol Protein-containing Complex Binding Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Dendritic Spine Maintenance Cellular Response To Amyloid-beta Glutamate Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport Regulation Of Protein Catabolic Process Regulation Of Cell Differentiation Regulation Of System Process Regulation Of Neuronal Synaptic Plasticity
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