AKT2 and PNPLA3

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		AKT2	PNPLA3
Gene Name		v-akt murine thymoma viral oncogene homolog 2	patatin-like phospholipase domain containing 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Plasma Membrane Cell Cortex Ruffle Membrane	Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity	Phospholipase A2 Activity Triglyceride Lipase Activity Mono-olein Transacylation Activity Diolein Transacylation Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation Glycogen Biosynthetic Process Glucose Metabolic Process Regulation Of Translation Cellular Protein Modification Process Protein Phosphorylation Apoptotic Process Signal Transduction Insulin Receptor Signaling Pathway Carbohydrate Transport Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Positive Regulation Of Glucose Metabolic Process Regulation Of Cell Migration Positive Regulation Of Vesicle Fusion Positive Regulation Of Fatty Acid Beta-oxidation Peripheral Nervous System Myelin Maintenance Activation Of Ral GTPase Activity Cellular Response To Insulin Stimulus Fat Cell Differentiation Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glucose Import Mammary Gland Epithelial Cell Differentiation Membrane Organization Intracellular Protein Transmembrane Transport Regulation Of Cell Cycle Arrest Protein Localization To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Cell Motility Positive Regulation Of Glucose Import In Response To Insulin Stimulus	Phospholipid Metabolic Process Triglyceride Biosynthetic Process Triglyceride Catabolic Process Acylglycerol Acyl-chain Remodeling Small Molecule Metabolic Process Glycerophospholipid Biosynthetic Process
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by GPCR Signaling by FGFR in disease Activation of BH3-only proteins mTOR signalling Signaling by Wnt Activation of PKB Signaling by EGFRvIII in Cancer AKT phosphorylates targets in the cytosol Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling Regulation of beta-cell development PI3K/AKT activation PI-3K cascade RNF mutants show enhanced WNT signaling and proliferation PDE3B signalling PKB-mediated events PI3K Cascade Signaling by PDGF Downregulation of ERBB2:ERBB3 signaling DAP12 interactions GAB1 signalosome misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling G-protein beta:gamma signalling CD28 co-stimulation CD28 dependent PI3K/Akt signaling PDE3B signalling Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by ERBB2 Activation of BAD and translocation to mitochondria Signaling by EGFR GPCR downstream signaling Signaling by VEGF AKT phosphorylates targets in the nucleus Downstream signal transduction Regulation of gene expression in beta cells Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling PI3K/AKT Signaling in Cancer Platelet activation, signaling and aggregation Adaptive Immune System Inhibition of TSC complex formation by PKB Activation of PKB Costimulation by the CD28 family IRS-mediated signalling PIP3 activates AKT signaling mTOR signalling Translocation of GLUT4 to the plasma membrane IGF1R signaling cascade deactivation of the beta-catenin transactivating complex VEGFA-VEGFR2 Pathway IRS-related events triggered by IGF1R G beta:gamma signalling through PI3Kgamma PI3K events in ERBB2 signaling VEGFR2 mediated vascular permeability Downstream signaling of activated FGFR Programmed Cell Death XAV939 inhibits tankyrase, stabilizing AXIN Intrinsic Pathway for Apoptosis Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade CTLA4 inhibitory signaling AKT-mediated inactivation of FOXO1A Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events NGF signalling via TRKA from the plasma membrane Negative regulation of the PI3K/AKT network Signaling by Overexpressed Wild-Type EGFR in Cancer Inhibition of TSC complex formation by PKB Signaling by FGFR IRS-mediated signalling TCF dependent signaling in response to WNT Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) GPVI-mediated activation cascade Signaling by WNT in cancer PKB-mediated events PI3K Cascade	Metabolism of lipids and lipoproteins Acyl chain remodeling of DAG and TAG Phospholipid metabolism Glycerophospholipid biosynthesis
Drugs		N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
Diseases
GWAS			Hematological and biochemical traits ( 20139978) Liver enzyme levels ( 18940312) Liver enzyme levels (alanine transaminase) ( 22001757) Metabolite levels ( 21909109) Non-alcoholic fatty liver disease ( 23535911) Nonalcoholic fatty liver disease ( 21423719 22719876)
Protein-Protein Interactions		38 interactors: ABCG8 AKT1 AKT1S1 APOA1 APOB APP APPL1 CCL14 CHUK CLIP3 ESR1 FOXO4 FSHR GSK3B HIST1H3A HSP90AA1 MAP3K5 MTCP1 NAMPT PDPK1 PLEKHO1 PNPLA3 POFUT1 POLR1B PRKDC RAB3D SH3RF1 SLC2A4 SNX27 SORBS2 SPRR2A STEAP4 TCL1A TCL1B TMED2 TRIB3 TSC2 XIAP	2 interactors: AKT2 SNX27
Entrez ID		208	80339
HPRD ID		01262	12430
Ensembl ID		ENSG00000105221	ENSG00000100344
Uniprot IDs		B4DG79 P31751	Q9NST1
PDB IDs		1GZK 1GZN 1GZO 1MRV 1MRY 1O6K 1O6L 1P6S 2JDO 2JDR 2UW9 2X39 2XH5 3D0E 3E87 3E88 3E8D
Enriched GO Terms of Interacting Partners?		Phosphatidylinositol-mediated Signaling Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fc Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Cellular Response To Insulin Stimulus Neurotrophin TRK Receptor Signaling Pathway Innate Immune Response Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Hormone Stimulus Response To Insulin Negative Regulation Of Catalytic Activity Cellular Response To Peptide Hormone Stimulus Immune Response-regulating Signaling Pathway Immune Response Cellular Response To Peptide Regulation Of Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Apoptotic Signaling Pathway Response To Hormone Insulin Receptor Signaling Pathway Immune System Process Response To Organic Substance Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Phosphorylation Response To Peptide Hormone Defense Response Response To Abiotic Stimulus Chemical Homeostasis Negative Regulation Of Protein Phosphorylation Cellular Response To Organonitrogen Compound Signal Transduction Regulation Of Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Protein Metabolic Process Response To Peptide Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Protein Kinase Activity Regulation Of Phosphorus Metabolic Process Apoptotic Process Cellular Response To Stimulus Negative Regulation Of Kinase Activity Regulation Of Protein Localization To Plasma Membrane Programmed Cell Death Cellular Response To Organic Substance	Establishment Of Natural Killer Cell Polarity Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Activation Of Ral GTPase Activity Positive Regulation Of Glucose Import In Response To Insulin Stimulus Positive Regulation Of Ral GTPase Activity Regulation Of Ral Protein Signal Transduction Retrograde Transport, Endosome To Plasma Membrane Positive Regulation Of Fatty Acid Beta-oxidation Regulation Of Glucose Import In Response To Insulin Stimulus Positive Regulation Of Vesicle Fusion Positive Regulation Of Glycogen Biosynthetic Process Peripheral Nervous System Myelin Maintenance Positive Regulation Of Fatty Acid Oxidation Regulation Of Fatty Acid Beta-oxidation Intracellular Protein Transport Mammary Gland Epithelial Cell Differentiation Positive Regulation Of Protein Targeting To Membrane Myelin Maintenance Negative Regulation Of Lipid Transport Positive Regulation Of Lipid Catabolic Process Glycogen Biosynthetic Process Regulation Of Vesicle Fusion Endosome To Lysosome Transport Regulation Of Glycogen Biosynthetic Process Regulation Of Fatty Acid Oxidation Positive Regulation Of Fatty Acid Metabolic Process Regulation Of Fatty Acid Transport Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Glucose Import Myelination In Peripheral Nervous System Regulation Of Glycogen Metabolic Process Cellular Polysaccharide Biosynthetic Process Cellular Protein Localization Positive Regulation Of Glucose Transport Schwann Cell Development Intracellular Protein Transmembrane Transport Protein Transport Polysaccharide Biosynthetic Process Lysosomal Transport Activation Of Ras GTPase Activity Establishment Of Protein Localization Negative Regulation Of Ion Transmembrane Transport Intracellular Transport Protein Transmembrane Transport Negative Regulation Of Transmembrane Transport Schwann Cell Differentiation Regulation Of Glucose Import Regulation Of Lipid Catabolic Process Glycogen Metabolic Process Natural Killer Cell Activation
Tagcloud ?		12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25	clues depdc5 directions dp dq exome g1896a gwass hbv hepatocarcinogenesis hla hotspots htert integrations kif1b landscape mica mutational pose possibilities rtm204i rtm204v shall technologies threats throughput transitions underlined warrant
Tagcloud (Difference) ?		12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25	clues depdc5 directions dp dq exome g1896a gwass hbv hepatocarcinogenesis hla hotspots htert integrations kif1b landscape mica mutational pose possibilities rtm204i rtm204v shall technologies threats throughput transitions underlined warrant
Tagcloud (Intersection) ?