AKT2 and SLC2A4

Number of citations of the paper that reports this interaction (PubMedID 11500317)
0

Data Source:
HPRD (in vitro)

		AKT2	SLC2A4
Description		AKT serine/threonine kinase 2	solute carrier family 2 member 4
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Cell Cortex Membrane Ruffle Membrane	Cytoplasm Endosome Multivesicular Body Trans-Golgi Network Cytosol Plasma Membrane Clathrin-coated Pit External Side Of Plasma Membrane Cell Surface Endomembrane System Vesicle Membrane Membrane Sarcoplasmic Reticulum Clathrin-coated Vesicle Trans-Golgi Network Transport Vesicle T-tubule Cytoplasmic Vesicle Membrane Vesicle Insulin-responsive Compartment Sarcolemma Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Presynapse
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity Molecular Function Activator Activity	Protein Binding D-glucose Uniporter Activity Transmembrane Transporter Activity D-glucose Transmembrane Transporter Activity
	Biological Process	Glycogen Metabolic Process Glycogen Biosynthetic Process Glucose Metabolic Process Regulation Of Translation Apoptotic Process Signal Transduction Insulin Receptor Signaling Pathway Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Positive Regulation Of Glucose Metabolic Process Regulation Of Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Fatty Acid Beta-oxidation Peripheral Nervous System Myelin Maintenance Cellular Response To Insulin Stimulus Intracellular Signal Transduction Protein Modification Process Negative Regulation Of Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Fat Cell Differentiation Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of D-glucose Import Protein Stabilization Regulation Of Cell Cycle Mammary Gland Epithelial Cell Differentiation Cellular Response To High Light Intensity Protein Localization To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane Retinal Rod Cell Apoptotic Process Positive Regulation Of Cap-dependent Translational Initiation Negative Regulation Of PERK-mediated Unfolded Protein Response Positive Regulation Of Cell Motility	Carbohydrate Metabolic Process Learning Or Memory Short-term Memory Long-term Memory Amylopectin Biosynthetic Process Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Cellular Response To Insulin Stimulus Glucose Homeostasis Glucose Import In Response To Insulin Stimulus Response To Ethanol D-glucose Import Brown Fat Cell Differentiation Transmembrane Transport White Fat Cell Proliferation Dehydroascorbic Acid Transport Cellular Response To Tumor Necrosis Factor Cellular Response To Hypoxia Cellular Response To Osmotic Stress Regulation Of Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Transport Across Blood-brain Barrier D-glucose Transmembrane Transport
Pathways		Activation of BAD and translocation to mitochondria PIP3 activates AKT signaling PIP3 activates AKT signaling Downregulation of ERBB2:ERBB3 signaling Translocation of SLC2A4 (GLUT4) to the plasma membrane Activation of AKT2 PDE3B signalling Inhibition of TSC complex formation by PKB AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the nucleus Negative regulation of the PI3K/AKT network AKT-mediated inactivation of FOXO1A Deactivation of the beta-catenin transactivating complex CD28 dependent PI3K/Akt signaling Co-inhibition by CTLA4 G beta:gamma signalling through PI3Kgamma VEGFR2 mediated vascular permeability TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation Regulation of TP53 Activity through Acetylation Regulation of TP53 Activity through Association with Co-factors Cyclin E associated events during G1/S transition Cyclin A:Cdk2-associated events at S phase entry RAB GEFs exchange GTP for GDP on RABs RUNX2 regulates genes involved in cell migration Regulation of PTEN stability and activity FLT3 Signaling Regulation of localization of FOXO transcription factors Estrogen-dependent nuclear events downstream of ESR-membrane signaling KEAP1-NFE2L2 pathway SARS-CoV-2 targets host intracellular signalling and regulatory pathways Regulation of MITF-M-dependent genes involved in pigmentation	Translocation of SLC2A4 (GLUT4) to the plasma membrane Cellular hexose transport Transcriptional regulation of white adipocyte differentiation
Drugs		N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
Diseases		Ovarian cancer Familial partial lipodystrophy (FPL), including the following four diseases: Kobberling-type lipodystrophy (FPLD1); Dunnigan-type lipodystrophy (FPLD2); Dunnigan-like lipodystrophy (FPLD3); AKT2 associated lipodystrophy
GWAS		Birth weight ( 31043758) Cerebrospinal fluid t-tau:AB1-42 ratio ( 26252872) Cerebrospinal T-tau levels ( 26252872) Diastolic blood pressure ( 28739976) Lean body mass ( 28552196) Lymphocyte count ( 32888494)	Alanine aminotransferase levels ( 34315874 33547301) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 34315874 33547301) Birth weight ( 23202124 31043758) Diastolic blood pressure ( 28135244) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Liver enzyme levels (alanine transaminase) ( 33972514) Medication use (diuretics) ( 31015401) Metabolite levels ( 22286219) Offspring birth weight ( 31043758) Pulse pressure ( 28135244) Systolic blood pressure ( 30578418) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Two-hour glucose ( 34059833)
Interacting Genes		43 interacting genes: ABCG8 AKT1 AKT1S1 APOA1 APOB APP APPL1 BLVRA CCL14 CDKN1A CHUK CLIP3 ESR1 FOXO4 FSHR GSK3B H3C1 HSP90AA1 MEOX2 MTCP1 NAMPT PDPK1 PICK1 PIP5K1C PLEKHO1 PNPLA3 POFUT1 POLR1B PRKDC RAB3D REL SH3RF1 SLC2A4 SORBS2 SORBS3 SPRR2A STEAP4 TCL1A TCL1B TMED2 TRIB3 TSC2 XIAP	40 interacting genes: ACOX1 ACTN1 ACTN4 AKT2 AP1M1 ARF3 ARFIP1 BSG C1QTNF5 CCDC116 CFL1 CREB3 CTSD DAXX DLD EHD2 ESYT2 FAR1 FKBP10 GAPDH HADH HK2 HSP90AA1 IDH2 KLHL41 LNPEP MAP1S MVP P3H1 P3H4 PDIA6 PRKAR1A PSMD7 RAB7A SERPINH1 SRFBP1 STRN3 UBA52 UBE2I UBE2N
Entrez ID		208	6517
HPRD ID		01262	00688
Ensembl ID		ENSG00000105221	ENSG00000181856
Uniprot IDs		B4DG79 P31751	P14672
PDB IDs		1GZK 1GZN 1GZO 1MRV 1MRY 1O6K 1O6L 1P6S 2JDO 2JDR 2UW9 2X39 2XH5 3D0E 3E87 3E88 3E8D 8Q61 9C1W	7WSM 7WSN
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Signal Transduction Regulation Of Intracellular Signal Transduction Insulin Receptor Signaling Pathway Cellular Response To Insulin Stimulus Response To Hormone Positive Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Nitric-oxide Synthase Regulator Activity Intracellular Signaling Cassette Regulation Of Innate Immune Response Cytosol Regulation Of Cell Communication Regulation Of Signaling Cellular Response To Hormone Stimulus Negative Regulation Of Signaling Negative Regulation Of Cell Communication Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Toll-like Receptor Signaling Pathway Response To Insulin Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Signal Transduction Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Gene Expression Positive Regulation Of Metabolic Process Chemical Homeostasis Low-density Lipoprotein Particle Regulation Of Vesicle-mediated Transport Cellular Response To Oxygen-containing Compound Cellular Response To Amyloid-beta Homeostatic Process Response To Peptide Hormone Endocytic Vesicle Lumen Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Catabolic Process Protein Kinase Binding Regulation Of Nitric Oxide Biosynthetic Process Very-low-density Lipoprotein Particle Response To Amyloid-beta Regulation Of Immune System Process Response To Stress Positive Regulation Of Signal Transduction Regulation Of Nitric Oxide Metabolic Process Response To Nutrient Levels Regulation Of Protein Modification Process Protein Serine/threonine Kinase Binding Cholesterol Transfer Activity Regulation Of Defense Response	Extracellular Exosome Perinuclear Region Of Cytoplasm Regulation Of Establishment Of Protein Localization Pseudopodium Catabolic Process Collagen Fibril Organization Regulation Of Protein Localization Regulation Of Protein Secretion Regulation Of Transport Cytosol Response To Unfolded Protein Regulation Of Protein Transport Melanosome Cellular Localization Actin Cytoskeleton Organization Cytoplasm Ficolin-1-rich Granule Lumen Oxidoreductase Activity Cortical Actin Cytoskeleton Intracellular Transport Regulation Of Matrix Metallopeptidase Secretion Regulation Of Secretion By Cell Organelle Organization Actin Filament-based Process Collagen Biosynthetic Process Positive Regulation Of Transport Intracellular Protein Localization Establishment Of Protein Localization Protein Metabolic Process Regulation Of Secretion Collagen Metabolic Process Collagen Binding Macromolecule Catabolic Process Protein Catabolic Process Pyruvate Metabolic Process Protein Hydroxylation Monocarboxylic Acid Metabolic Process Protein Transport Response To Peptide Hormone Ubiquitin Protein Ligase Binding 2-oxoglutarate Metabolic Process Generation Of Precursor Metabolites And Energy Fatty Acid Derivative Metabolic Process Protein Localization To Plasma Membrane Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, NAD Or NADP As Acceptor Protein Homodimerization Activity Actin Filament Binding Very Long-chain Fatty Acid Beta-oxidation Cytoskeleton Organization Positive Regulation Of Cell Motility
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