AKT2 and SPRR2A

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		AKT2	SPRR2A
Description		AKT serine/threonine kinase 2	small proline rich protein 2A
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Cell Cortex Membrane Ruffle Membrane	Cornified Envelope Extracellular Region Cytoplasm Cytosol Transport Vesicle Secretory Granule Cytoplasmic Vesicle
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity Molecular Function Activator Activity	Protein Binding Lipid Binding
	Biological Process	Glycogen Metabolic Process Glycogen Biosynthetic Process Glucose Metabolic Process Regulation Of Translation Apoptotic Process Signal Transduction Insulin Receptor Signaling Pathway Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Positive Regulation Of Glucose Metabolic Process Regulation Of Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Fatty Acid Beta-oxidation Peripheral Nervous System Myelin Maintenance Cellular Response To Insulin Stimulus Intracellular Signal Transduction Protein Modification Process Negative Regulation Of Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Fat Cell Differentiation Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of D-glucose Import Protein Stabilization Regulation Of Cell Cycle Mammary Gland Epithelial Cell Differentiation Cellular Response To High Light Intensity Protein Localization To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane Retinal Rod Cell Apoptotic Process Positive Regulation Of Cap-dependent Translational Initiation Negative Regulation Of PERK-mediated Unfolded Protein Response Positive Regulation Of Cell Motility	Antibacterial Humoral Response Defense Response To Bacterium Host-mediated Modulation Of Intestinal Microbiota Composition Defense Response To Gram-positive Bacterium
Pathways		Activation of BAD and translocation to mitochondria PIP3 activates AKT signaling PIP3 activates AKT signaling Downregulation of ERBB2:ERBB3 signaling Translocation of SLC2A4 (GLUT4) to the plasma membrane Activation of AKT2 PDE3B signalling Inhibition of TSC complex formation by PKB AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the nucleus Negative regulation of the PI3K/AKT network AKT-mediated inactivation of FOXO1A Deactivation of the beta-catenin transactivating complex CD28 dependent PI3K/Akt signaling Co-inhibition by CTLA4 G beta:gamma signalling through PI3Kgamma VEGFR2 mediated vascular permeability TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation Regulation of TP53 Activity through Acetylation Regulation of TP53 Activity through Association with Co-factors Cyclin E associated events during G1/S transition Cyclin A:Cdk2-associated events at S phase entry RAB GEFs exchange GTP for GDP on RABs RUNX2 regulates genes involved in cell migration Regulation of PTEN stability and activity FLT3 Signaling Regulation of localization of FOXO transcription factors Estrogen-dependent nuclear events downstream of ESR-membrane signaling KEAP1-NFE2L2 pathway SARS-CoV-2 targets host intracellular signalling and regulatory pathways Regulation of MITF-M-dependent genes involved in pigmentation	Formation of the cornified envelope Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
Drugs		N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
Diseases		Ovarian cancer Familial partial lipodystrophy (FPL), including the following four diseases: Kobberling-type lipodystrophy (FPLD1); Dunnigan-type lipodystrophy (FPLD2); Dunnigan-like lipodystrophy (FPLD3); AKT2 associated lipodystrophy
GWAS		Birth weight ( 31043758) Cerebrospinal fluid t-tau:AB1-42 ratio ( 26252872) Cerebrospinal T-tau levels ( 26252872) Diastolic blood pressure ( 28739976) Lean body mass ( 28552196) Lymphocyte count ( 32888494)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011)
Interacting Genes		43 interacting genes: ABCG8 AKT1 AKT1S1 APOA1 APOB APP APPL1 BLVRA CCL14 CDKN1A CHUK CLIP3 ESR1 FOXO4 FSHR GSK3B H3C1 HSP90AA1 MEOX2 MTCP1 NAMPT PDPK1 PICK1 PIP5K1C PLEKHO1 PNPLA3 POFUT1 POLR1B PRKDC RAB3D REL SH3RF1 SLC2A4 SORBS2 SORBS3 SPRR2A STEAP4 TCL1A TCL1B TMED2 TRIB3 TSC2 XIAP	10 interacting genes: ABL1 AKT2 CRK CTTN DLG4 EVPL HCK ITK PEX13 YES1
Entrez ID		208	6700
HPRD ID		01262	01649
Ensembl ID		ENSG00000105221	ENSG00000241794
Uniprot IDs		B4DG79 P31751	P35326
PDB IDs		1GZK 1GZN 1GZO 1MRV 1MRY 1O6K 1O6L 1P6S 2JDO 2JDR 2UW9 2X39 2XH5 3D0E 3E87 3E88 3E8D 8Q61 9C1W
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Signal Transduction Regulation Of Intracellular Signal Transduction Insulin Receptor Signaling Pathway Cellular Response To Insulin Stimulus Response To Hormone Positive Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Nitric-oxide Synthase Regulator Activity Intracellular Signaling Cassette Regulation Of Innate Immune Response Cytosol Regulation Of Cell Communication Regulation Of Signaling Cellular Response To Hormone Stimulus Negative Regulation Of Signaling Negative Regulation Of Cell Communication Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Toll-like Receptor Signaling Pathway Response To Insulin Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Signal Transduction Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Gene Expression Positive Regulation Of Metabolic Process Chemical Homeostasis Low-density Lipoprotein Particle Regulation Of Vesicle-mediated Transport Cellular Response To Oxygen-containing Compound Cellular Response To Amyloid-beta Homeostatic Process Response To Peptide Hormone Endocytic Vesicle Lumen Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Catabolic Process Protein Kinase Binding Regulation Of Nitric Oxide Biosynthetic Process Very-low-density Lipoprotein Particle Response To Amyloid-beta Regulation Of Immune System Process Response To Stress Positive Regulation Of Signal Transduction Regulation Of Nitric Oxide Metabolic Process Response To Nutrient Levels Regulation Of Protein Modification Process Protein Serine/threonine Kinase Binding Cholesterol Transfer Activity Regulation Of Defense Response	Phosphotyrosine Residue Binding Non-membrane Spanning Protein Tyrosine Kinase Activity Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Protein Tyrosine Kinase Activity Fc-gamma Receptor Signaling Pathway Cytosol Ephrin Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Fc Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Protein Kinase Activity Regulation Of Immune Response Response To Transforming Growth Factor Beta Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Motility Actin Filament Immune Response-regulating Cell Surface Receptor Signaling Pathway Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Actin Cytoskeleton Organization Immune Response-activating Signaling Pathway Proline-rich Region Binding Regulation Of Actin Filament-based Process Anchoring Junction Immune Response-regulating Signaling Pathway Activation Of Immune Response Cellular Response To Oxygen-containing Compound Response To Reactive Oxygen Species Ephrin Receptor Binding Cell Migration Cortical Cytoskeleton Positive Regulation Of Supramolecular Fiber Organization Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Immune System Process Dendritic Spine Organization Positive Regulation Of Cytoskeleton Organization Protein Modification Process Regulation Of Cytoskeleton Organization Negative Regulation Of Immune Response Regulation Of Biological Quality Intracellular Protein Localization SH2 Domain Binding Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Neuron Projection Organization Postsynapse Organization Postsynapse Leukocyte Migration Positive Regulation Of Locomotion
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