AKT2 and HIST1H3A

Number of citations of the paper that reports this interaction (PMID 22158034)
4

Data Source:
BioGRID (enzymatic study)

		AKT2	HIST1H3A
Gene Name		v-akt murine thymoma viral oncogene homolog 2	histone cluster 1, H3a
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Plasma Membrane Cell Cortex Ruffle Membrane	Nuclear Chromosome Nucleosome Extracellular Region Nucleus Nucleoplasm Membrane Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity	DNA Binding Protein Binding Protein Heterodimerization Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation Glycogen Biosynthetic Process Glucose Metabolic Process Regulation Of Translation Cellular Protein Modification Process Protein Phosphorylation Apoptotic Process Signal Transduction Insulin Receptor Signaling Pathway Carbohydrate Transport Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Positive Regulation Of Glucose Metabolic Process Regulation Of Cell Migration Positive Regulation Of Vesicle Fusion Positive Regulation Of Fatty Acid Beta-oxidation Peripheral Nervous System Myelin Maintenance Activation Of Ral GTPase Activity Cellular Response To Insulin Stimulus Fat Cell Differentiation Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glucose Import Mammary Gland Epithelial Cell Differentiation Membrane Organization Intracellular Protein Transmembrane Transport Regulation Of Cell Cycle Arrest Protein Localization To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Cell Motility Positive Regulation Of Glucose Import In Response To Insulin Stimulus	Chromatin Silencing At RDNA Chromatin Organization DNA Replication-dependent Nucleosome Assembly Blood Coagulation Gene Expression DNA Methylation On Cytosine Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Silencing
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by GPCR Signaling by FGFR in disease Activation of BH3-only proteins mTOR signalling Signaling by Wnt Activation of PKB Signaling by EGFRvIII in Cancer AKT phosphorylates targets in the cytosol Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling Regulation of beta-cell development PI3K/AKT activation PI-3K cascade RNF mutants show enhanced WNT signaling and proliferation PDE3B signalling PKB-mediated events PI3K Cascade Signaling by PDGF Downregulation of ERBB2:ERBB3 signaling DAP12 interactions GAB1 signalosome misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling G-protein beta:gamma signalling CD28 co-stimulation CD28 dependent PI3K/Akt signaling PDE3B signalling Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by ERBB2 Activation of BAD and translocation to mitochondria Signaling by EGFR GPCR downstream signaling Signaling by VEGF AKT phosphorylates targets in the nucleus Downstream signal transduction Regulation of gene expression in beta cells Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling PI3K/AKT Signaling in Cancer Platelet activation, signaling and aggregation Adaptive Immune System Inhibition of TSC complex formation by PKB Activation of PKB Costimulation by the CD28 family IRS-mediated signalling PIP3 activates AKT signaling mTOR signalling Translocation of GLUT4 to the plasma membrane IGF1R signaling cascade deactivation of the beta-catenin transactivating complex VEGFA-VEGFR2 Pathway IRS-related events triggered by IGF1R G beta:gamma signalling through PI3Kgamma PI3K events in ERBB2 signaling VEGFR2 mediated vascular permeability Downstream signaling of activated FGFR Programmed Cell Death XAV939 inhibits tankyrase, stabilizing AXIN Intrinsic Pathway for Apoptosis Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade CTLA4 inhibitory signaling AKT-mediated inactivation of FOXO1A Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events NGF signalling via TRKA from the plasma membrane Negative regulation of the PI3K/AKT network Signaling by Overexpressed Wild-Type EGFR in Cancer Inhibition of TSC complex formation by PKB Signaling by FGFR IRS-mediated signalling TCF dependent signaling in response to WNT Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) GPVI-mediated activation cascade Signaling by WNT in cancer PKB-mediated events PI3K Cascade	RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase PKMTs methylate histone lysines Regulatory RNA pathways RNA Polymerase I Promoter Clearance HDMs demethylate histones Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination HDACs deacetylate histones Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression Factors involved in megakaryocyte development and platelet production PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs		N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
Diseases
GWAS
Protein-Protein Interactions		38 interactors: ABCG8 AKT1 AKT1S1 APOA1 APOB APP APPL1 CCL14 CHUK CLIP3 ESR1 FOXO4 FSHR GSK3B HIST1H3A HSP90AA1 MAP3K5 MTCP1 NAMPT PDPK1 PLEKHO1 PNPLA3 POFUT1 POLR1B PRKDC RAB3D SH3RF1 SLC2A4 SNX27 SORBS2 SPRR2A STEAP4 TCL1A TCL1B TMED2 TRIB3 TSC2 XIAP	117 interactors: AIRE AKT2 ALL1 ANP32A ASH1L ASH2L ATRX ATXN1 ATXN7 AURKB AURKC BAZ1B CALCOCO1 CARM1 CBX1 CBX3 CHD4 COPS2 CREBBP CTCFL CUL4A DDB1 DNMT3A DPF2 DYRK1A EED EHMT1 EHMT2 EID1 EP300 ERCC6 ESCO1 EZH2 FBLIM1 GATAD2A GATAD2B GRIP1 GSG2 HDAC2 HDAC8 HIST1H4A HIST2H2AC HIST2H4A HNF1B ING4 KAT2A KAT2B KAT5 KAT6A KAT7 KDM1A KDM2B KDM4A KDM4C KDM6A KDM6B KMT2A KMT2B KMT2C L3MBTL2 LBR LOXL2 MEN1 MSL3 MYOD1 NCOR1 NPM1 NR1H4 PAF1 PAK1 PARP10 PAXIP1 PBRM1 PHF1 PHF20 PHF8 PRDM2 PRKCA PRKCB PRMT1 PRMT5 PRMT7 RAD51B RAG1 RCC1 RPS6KA3 SET SETD1A SETD1B SETD2 SETD7 SETDB1 SIRT1 SIRT2 SIRT7 SMARCA2 SMARCA4 SMARCA5 SNAI1 SSRP1 SUV39H1 TAF1 TAF15 TAF1A TAF1B THAP7 TRIM24 TRIM33 TSSK6 UHRF1 UHRF2 VPRBP WHSC1 WWC1 YWHAB YWHAG YWHAZ
Entrez ID		208	8350
HPRD ID		01262	04155
Ensembl ID		ENSG00000105221	ENSG00000198366
Uniprot IDs		B4DG79 P31751	P68431
PDB IDs		1GZK 1GZN 1GZO 1MRV 1MRY 1O6K 1O6L 1P6S 2JDO 2JDR 2UW9 2X39 2XH5 3D0E 3E87 3E88 3E8D	1CS9 1CT6 1Q3L 2B2T 2B2U 2B2V 2B2W 2C1J 2C1N 2CV5 2KWJ 2KWK 2L75 2LBM 2M0O 2RI7 2UXN 3A1B 3AFA 3AVR 3AYW 3AZE 3AZF 3AZG 3AZH 3AZI 3AZJ 3AZK 3AZL 3AZM 3AZN 3B95 3KMT 3KQI 3LQI 3LQJ 3O34 3O35 3O37 3RIG 3RIY 3U4S 3U5N 3U5O 3U5P 3UEE 3UEF 3UIG 3UII 3UIK 3V43 3W96 3W97 3W98 3W99 3ZG6 3ZVY 4A0J 4A0N 4A7J 4BD3 4F4U 4F56 4FWF 4HON 4I51
Enriched GO Terms of Interacting Partners?		Phosphatidylinositol-mediated Signaling Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fc Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Cellular Response To Insulin Stimulus Neurotrophin TRK Receptor Signaling Pathway Innate Immune Response Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Hormone Stimulus Response To Insulin Negative Regulation Of Catalytic Activity Cellular Response To Peptide Hormone Stimulus Immune Response-regulating Signaling Pathway Immune Response Cellular Response To Peptide Regulation Of Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Apoptotic Signaling Pathway Response To Hormone Insulin Receptor Signaling Pathway Immune System Process Response To Organic Substance Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Phosphorylation Response To Peptide Hormone Defense Response Response To Abiotic Stimulus Chemical Homeostasis Negative Regulation Of Protein Phosphorylation Cellular Response To Organonitrogen Compound Signal Transduction Regulation Of Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Protein Metabolic Process Response To Peptide Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Protein Kinase Activity Regulation Of Phosphorus Metabolic Process Apoptotic Process Cellular Response To Stimulus Negative Regulation Of Kinase Activity Regulation Of Protein Localization To Plasma Membrane Programmed Cell Death Cellular Response To Organic Substance	Chromatin Modification Chromatin Organization Histone Modification Chromosome Organization Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Biosynthetic Process Organelle Organization Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process RNA Metabolic Process Macromolecule Biosynthetic Process Peptidyl-lysine Modification Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Cellular Protein Modification Process Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Peptidyl-amino Acid Modification Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Gene Expression Histone Methylation Negative Regulation Of RNA Biosynthetic Process Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Protein Methylation Cellular Metabolic Process Methylation Regulation Of Cellular Process Cellular Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression, Epigenetic Histone Lysine Methylation Peptidyl-lysine Methylation Negative Regulation Of Transcription From RNA Polymerase II Promoter Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression
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Tagcloud (Difference) ?		12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25	1st affymetrix barcoding capn6 comprehensively corneal corneas dystrophies dystrophy fecd fecd4 fuchs genechip hcenc hspa2 hybridized itgbl1 nalcn partek polymorphous ppcd ppcd1 prex2 scientists suite tac1 tmod1 xecd
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