AKT2 and NAMPT

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		AKT2	NAMPT
Gene Name		v-akt murine thymoma viral oncogene homolog 2	nicotinamide phosphoribosyltransferase
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Plasma Membrane Cell Cortex Ruffle Membrane	Extracellular Space Nucleus Cytosol Extracellular Vesicular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity	Nicotinate-nucleotide Diphosphorylase (carboxylating) Activity Cytokine Activity Protein Binding Drug Binding Protein Homodimerization Activity Nicotinamide Phosphoribosyltransferase Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation Glycogen Biosynthetic Process Glucose Metabolic Process Regulation Of Translation Cellular Protein Modification Process Protein Phosphorylation Apoptotic Process Signal Transduction Insulin Receptor Signaling Pathway Carbohydrate Transport Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Positive Regulation Of Glucose Metabolic Process Regulation Of Cell Migration Positive Regulation Of Vesicle Fusion Positive Regulation Of Fatty Acid Beta-oxidation Peripheral Nervous System Myelin Maintenance Activation Of Ral GTPase Activity Cellular Response To Insulin Stimulus Fat Cell Differentiation Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glucose Import Mammary Gland Epithelial Cell Differentiation Membrane Organization Intracellular Protein Transmembrane Transport Regulation Of Cell Cycle Arrest Protein Localization To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Cell Motility Positive Regulation Of Glucose Import In Response To Insulin Stimulus	Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Nicotinamide Metabolic Process Signal Transduction Cell-cell Signaling Female Pregnancy Circadian Rhythm Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway NAD Biosynthetic Process Response To Organic Cyclic Compound NAD Metabolic Process Circadian Regulation Of Gene Expression Small Molecule Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Adipose Tissue Development
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by GPCR Signaling by FGFR in disease Activation of BH3-only proteins mTOR signalling Signaling by Wnt Activation of PKB Signaling by EGFRvIII in Cancer AKT phosphorylates targets in the cytosol Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling Regulation of beta-cell development PI3K/AKT activation PI-3K cascade RNF mutants show enhanced WNT signaling and proliferation PDE3B signalling PKB-mediated events PI3K Cascade Signaling by PDGF Downregulation of ERBB2:ERBB3 signaling DAP12 interactions GAB1 signalosome misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling G-protein beta:gamma signalling CD28 co-stimulation CD28 dependent PI3K/Akt signaling PDE3B signalling Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by ERBB2 Activation of BAD and translocation to mitochondria Signaling by EGFR GPCR downstream signaling Signaling by VEGF AKT phosphorylates targets in the nucleus Downstream signal transduction Regulation of gene expression in beta cells Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling PI3K/AKT Signaling in Cancer Platelet activation, signaling and aggregation Adaptive Immune System Inhibition of TSC complex formation by PKB Activation of PKB Costimulation by the CD28 family IRS-mediated signalling PIP3 activates AKT signaling mTOR signalling Translocation of GLUT4 to the plasma membrane IGF1R signaling cascade deactivation of the beta-catenin transactivating complex VEGFA-VEGFR2 Pathway IRS-related events triggered by IGF1R G beta:gamma signalling through PI3Kgamma PI3K events in ERBB2 signaling VEGFR2 mediated vascular permeability Downstream signaling of activated FGFR Programmed Cell Death XAV939 inhibits tankyrase, stabilizing AXIN Intrinsic Pathway for Apoptosis Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade CTLA4 inhibitory signaling AKT-mediated inactivation of FOXO1A Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events NGF signalling via TRKA from the plasma membrane Negative regulation of the PI3K/AKT network Signaling by Overexpressed Wild-Type EGFR in Cancer Inhibition of TSC complex formation by PKB Signaling by FGFR IRS-mediated signalling TCF dependent signaling in response to WNT Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) GPVI-mediated activation cascade Signaling by WNT in cancer PKB-mediated events PI3K Cascade	Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective GIF causes intrinsic factor deficiency Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MMAA causes methylmalonic aciduria type cblA Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective CUBN causes hereditary megaloblastic anemia 1 Defective AMN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Nicotinamide salvaging Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia BMAL1:CLOCK,NPAS2 activates circadian gene expression Nicotinate metabolism Defects in cobalamin (B12) metabolism Defects in vitamin and cofactor metabolism
Drugs		N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
Diseases
GWAS
Protein-Protein Interactions		38 interactors: ABCG8 AKT1 AKT1S1 APOA1 APOB APP APPL1 CCL14 CHUK CLIP3 ESR1 FOXO4 FSHR GSK3B HIST1H3A HSP90AA1 MAP3K5 MTCP1 NAMPT PDPK1 PLEKHO1 PNPLA3 POFUT1 POLR1B PRKDC RAB3D SH3RF1 SLC2A4 SNX27 SORBS2 SPRR2A STEAP4 TCL1A TCL1B TMED2 TRIB3 TSC2 XIAP	4 interactors: ADORA2A AKT2 FANCA GGT1
Entrez ID		208	10135
HPRD ID		01262	09938
Ensembl ID		ENSG00000105221	ENSG00000105835
Uniprot IDs		B4DG79 P31751	P43490
PDB IDs		1GZK 1GZN 1GZO 1MRV 1MRY 1O6K 1O6L 1P6S 2JDO 2JDR 2UW9 2X39 2XH5 3D0E 3E87 3E88 3E8D	2E5B 2E5C 2E5D 2GVG 2GVJ 3DGR 3DHD 3DHF 3DKJ 3DKL 4JNM 4JR5 4KFN 4KFO 4KFP 4LV9 4LVA 4LVB 4LVD 4LVF 4LVG 4M6P 4M6Q
Enriched GO Terms of Interacting Partners?		Phosphatidylinositol-mediated Signaling Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fc Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Cellular Response To Insulin Stimulus Neurotrophin TRK Receptor Signaling Pathway Innate Immune Response Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Hormone Stimulus Response To Insulin Negative Regulation Of Catalytic Activity Cellular Response To Peptide Hormone Stimulus Immune Response-regulating Signaling Pathway Immune Response Cellular Response To Peptide Regulation Of Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Apoptotic Signaling Pathway Response To Hormone Insulin Receptor Signaling Pathway Immune System Process Response To Organic Substance Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Phosphorylation Response To Peptide Hormone Defense Response Response To Abiotic Stimulus Chemical Homeostasis Negative Regulation Of Protein Phosphorylation Cellular Response To Organonitrogen Compound Signal Transduction Regulation Of Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Protein Metabolic Process Response To Peptide Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Protein Kinase Activity Regulation Of Phosphorus Metabolic Process Apoptotic Process Cellular Response To Stimulus Negative Regulation Of Kinase Activity Regulation Of Protein Localization To Plasma Membrane Programmed Cell Death Cellular Response To Organic Substance	Glutathione Catabolic Process Activation Of Ral GTPase Activity Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Cysteine Biosynthetic Process Positive Regulation Of Glucose Import In Response To Insulin Stimulus Positive Regulation Of Ral GTPase Activity Regulation Of Ral Protein Signal Transduction Positive Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Cysteine Metabolic Process Regulation Of Glucose Import In Response To Insulin Stimulus Positive Regulation Of Fatty Acid Beta-oxidation Adenosine Receptor Signaling Pathway Positive Regulation Of Vesicle Fusion Peptide Catabolic Process Positive Regulation Of Glycogen Biosynthetic Process Peripheral Nervous System Myelin Maintenance Positive Regulation Of Fatty Acid Oxidation Regulation Of Fatty Acid Beta-oxidation Cellular Modified Amino Acid Catabolic Process Sulfur Amino Acid Biosynthetic Process CAMP Biosynthetic Process Mammary Gland Epithelial Cell Differentiation Positive Regulation Of Protein Targeting To Membrane Negative Regulation Of Lipid Transport Myelin Maintenance Leukotriene Biosynthetic Process Glutathione Biosynthetic Process Glutathione Derivative Biosynthetic Process Glutamate Metabolic Process Positive Regulation Of Lipid Catabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Glycogen Biosynthetic Process Regulation Of Vesicle Fusion Activation Of Adenylate Cyclase Activity Peptide Biosynthetic Process Positive Regulation Of Fatty Acid Metabolic Process Regulation Of Glycogen Biosynthetic Process Regulation Of Fatty Acid Oxidation Regulation Of Fatty Acid Transport Leukotriene Metabolic Process Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Glucose Import Cellular Response To Stimulus Myelination In Peripheral Nervous System CAMP Metabolic Process Regulation Of Glycogen Metabolic Process Cellular Polysaccharide Biosynthetic Process Positive Regulation Of Glucose Transport
Tagcloud ?		12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25	atp attribute autophagy concurrent connect deacetylases deacetylate depleted depletion driven fail gne illustrates inability k40 k9 limiting lose metabolite motility nad oncology oncosis predominant regenerate reveals slower tubulin utilize
Tagcloud (Difference) ?		12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25	atp attribute autophagy concurrent connect deacetylases deacetylate depleted depletion driven fail gne illustrates inability k40 k9 limiting lose metabolite motility nad oncology oncosis predominant regenerate reveals slower tubulin utilize
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