Wiki-Pi
About
Search
People
Updates
Search
AKT2 and CHUK
Number of citations of the paper that reports this interaction (PubMedID
12048203
)
0
Data Source:
HPRD
(in vivo, in vitro)
AKT2
CHUK
Description
AKT serine/threonine kinase 2
component of inhibitor of nuclear factor kappa B kinase complex
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Early Endosome
Cytosol
Plasma Membrane
Cell Cortex
Membrane
Ruffle Membrane
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
IkappaB Kinase Complex
Cytoplasmic Side Of Plasma Membrane
CD40 Receptor Complex
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Metal Ion Binding
Protein Serine Kinase Activity
Molecular Function Activator Activity
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
IkappaB Kinase Activity
Kinase Activity
Transferase Activity
Protein Homodimerization Activity
Protein-containing Complex Binding
Protein Heterodimerization Activity
Scaffold Protein Binding
Transferrin Receptor Binding
Biological Process
Glycogen Metabolic Process
Glycogen Biosynthetic Process
Glucose Metabolic Process
Regulation Of Translation
Apoptotic Process
Signal Transduction
Insulin Receptor Signaling Pathway
Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane
Positive Regulation Of Glucose Metabolic Process
Regulation Of Cell Migration
Positive Regulation Of Cell Migration
Positive Regulation Of Fatty Acid Beta-oxidation
Peripheral Nervous System Myelin Maintenance
Cellular Response To Insulin Stimulus
Intracellular Signal Transduction
Protein Modification Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Fat Cell Differentiation
Positive Regulation Of Glycogen Biosynthetic Process
Positive Regulation Of D-glucose Import
Protein Stabilization
Regulation Of Cell Cycle
Mammary Gland Epithelial Cell Differentiation
Cellular Response To High Light Intensity
Protein Localization To Plasma Membrane
Positive Regulation Of Protein Targeting To Membrane
Retinal Rod Cell Apoptotic Process
Positive Regulation Of Cap-dependent Translational Initiation
Negative Regulation Of PERK-mediated Unfolded Protein Response
Positive Regulation Of Cell Motility
Pattern Recognition Receptor Signaling Pathway
Skeletal Muscle Contraction
Regulation Of Transcription By RNA Polymerase II
Inflammatory Response
Immune Response
Canonical NF-kappaB Signal Transduction
Response To Xenobiotic Stimulus
Response To Virus
Response To Toxic Substance
Anatomical Structure Morphogenesis
Response To Acetate
Negative Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Interferon-alpha Production
Response To Hydroperoxide
Tumor Necrosis Factor-mediated Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Non-canonical NF-kappaB Signal Transduction
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Response To Amino Acid
Innate Immune Response
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of NF-kappaB Transcription Factor Activity
Striated Muscle Cell Differentiation
Response To Cholecystokinin
Cellular Response To Tumor Necrosis Factor
Cellular Response To Virus
Pathways
Activation of BAD and translocation to mitochondria
PIP3 activates AKT signaling
PIP3 activates AKT signaling
Downregulation of ERBB2:ERBB3 signaling
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Activation of AKT2
PDE3B signalling
Inhibition of TSC complex formation by PKB
AKT phosphorylates targets in the cytosol
AKT phosphorylates targets in the cytosol
AKT phosphorylates targets in the nucleus
Negative regulation of the PI3K/AKT network
AKT-mediated inactivation of FOXO1A
Deactivation of the beta-catenin transactivating complex
CD28 dependent PI3K/Akt signaling
Co-inhibition by CTLA4
G beta:gamma signalling through PI3Kgamma
VEGFR2 mediated vascular permeability
TP53 Regulates Metabolic Genes
Constitutive Signaling by AKT1 E17K in Cancer
Regulation of TP53 Degradation
Regulation of TP53 Activity through Acetylation
Regulation of TP53 Activity through Association with Co-factors
Cyclin E associated events during G1/S transition
Cyclin A:Cdk2-associated events at S phase entry
RAB GEFs exchange GTP for GDP on RABs
RUNX2 regulates genes involved in cell migration
Regulation of PTEN stability and activity
FLT3 Signaling
Regulation of localization of FOXO transcription factors
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
KEAP1-NFE2L2 pathway
SARS-CoV-2 targets host intracellular signalling and regulatory pathways
Regulation of MITF-M-dependent genes involved in pigmentation
Activation of NF-kappaB in B cells
Activation of NF-kappaB in B cells
ER-Phagosome pathway
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
RIP-mediated NFkB activation via ZBP1
AKT phosphorylates targets in the cytosol
Downstream TCR signaling
FCERI mediated NF-kB activation
TAK1-dependent IKK and NF-kappa-B activation
Regulation of TNFR1 signaling
TNFR1-induced NF-kappa-B signaling pathway
IKBKB deficiency causes SCID
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
IkBA variant leads to EDA-ID
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Constitutive Signaling by AKT1 E17K in Cancer
NIK-->noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
SARS-CoV-2 activates/modulates innate and adaptive immune responses
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Regulation of NF-kappa B signaling
PKR-mediated signaling
SLC15A4:TASL-dependent IRF5 activation
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Modulation of host responses by IFN-stimulated genes
Drugs
N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide
4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE
ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE
(2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
Aminosalicylic acid
Mesalazine
Acetylcysteine
Diseases
Ovarian cancer
Familial partial lipodystrophy (FPL), including the following four diseases: Kobberling-type lipodystrophy (FPLD1); Dunnigan-type lipodystrophy (FPLD2); Dunnigan-like lipodystrophy (FPLD3); AKT2 associated lipodystrophy
Cocoon syndrome
GWAS
Birth weight (
31043758
)
Cerebrospinal fluid t-tau:AB1-42 ratio (
26252872
)
Cerebrospinal T-tau levels (
26252872
)
Diastolic blood pressure (
28739976
)
Lean body mass (
28552196
)
Lymphocyte count (
32888494
)
Liver enzyme levels (
18940312
)
Psoriasis (
28537254
)
Psoriasis or type 2 diabetes (trans-disease meta-analysis) (
33385400
)
Type 2 diabetes (
30054458
)
Interacting Genes
43 interacting genes:
ABCG8
AKT1
AKT1S1
APOA1
APOB
APP
APPL1
BLVRA
CCL14
CDKN1A
CHUK
CLIP3
ESR1
FOXO4
FSHR
GSK3B
H3C1
HSP90AA1
MEOX2
MTCP1
NAMPT
PDPK1
PICK1
PIP5K1C
PLEKHO1
PNPLA3
POFUT1
POLR1B
PRKDC
RAB3D
REL
SH3RF1
SLC2A4
SORBS2
SORBS3
SPRR2A
STEAP4
TCL1A
TCL1B
TMED2
TRIB3
TSC2
XIAP
85 interacting genes:
AKT1
AKT2
AMBRA1
ATM
ATR
BCL10
BCL3
BTRC
CASP8
CDC37
CHEK1
CREBBP
CSF2RA
CSNK2A1
CTNNB1
CUEDC2
CUL1
DCUN1D5
E2F4
EIF2AK2
ELP1
ERBIN
ESR1
FKBP5
FOXO3
H3-4
H3C1
H3C14
HECTD3
HSP90AA1
HSP90AB1
HTT
IKBKB
IKBKE
IKBKG
IRS1
MAP3K1
MAP3K11
MAP3K14
MAP3K4
MAP3K7
MAP3K8
MYC
NCOA3
NCOR1
NCOR2
NFKB1
NFKB2
NFKBIA
NFKBIB
NLRP4
NOTCH3
NR2C2
PAX8
PEBP1
PIAS1
PRKCB
PRKCI
PRKCQ
PRKDC
PTPN11
RELA
RICTOR
RIPK2
RPL27
SAMHD1
SRC
SRPK1
SRPK2
STAP2
TANK
TGFBR1
TNFAIP3
TNFRSF1A
TP53
TRAF2
TRAF3IP2
TRAF4
TRIM27
TRPC4AP
TTC3
UBC
UBE2E3
UBE2I
UBE2N
Entrez ID
208
1147
HPRD ID
01262
02811
Ensembl ID
ENSG00000105221
ENSG00000213341
Uniprot IDs
B4DG79
P31751
O15111
PDB IDs
1GZK
1GZN
1GZO
1MRV
1MRY
1O6K
1O6L
1P6S
2JDO
2JDR
2UW9
2X39
2XH5
3D0E
3E87
3E88
3E8D
8Q61
9C1W
3BRT
5EBZ
5TQW
5TQX
5TQY
Enriched GO Terms of Interacting Partners
?
Intracellular Signal Transduction
Signal Transduction
Regulation Of Intracellular Signal Transduction
Insulin Receptor Signaling Pathway
Cellular Response To Insulin Stimulus
Response To Hormone
Positive Regulation Of Protein Metabolic Process
Regulation Of Signal Transduction
Nitric-oxide Synthase Regulator Activity
Intracellular Signaling Cassette
Regulation Of Innate Immune Response
Cytosol
Regulation Of Cell Communication
Regulation Of Signaling
Cellular Response To Hormone Stimulus
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Positive Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Toll-like Receptor Signaling Pathway
Response To Insulin
Positive Regulation Of Nitric Oxide Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Signal Transduction
Cellular Response To Peptide Hormone Stimulus
Positive Regulation Of Gene Expression
Positive Regulation Of Metabolic Process
Chemical Homeostasis
Low-density Lipoprotein Particle
Regulation Of Vesicle-mediated Transport
Cellular Response To Oxygen-containing Compound
Cellular Response To Amyloid-beta
Homeostatic Process
Response To Peptide Hormone
Endocytic Vesicle Lumen
Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Protein Catabolic Process
Protein Kinase Binding
Regulation Of Nitric Oxide Biosynthetic Process
Very-low-density Lipoprotein Particle
Response To Amyloid-beta
Regulation Of Immune System Process
Response To Stress
Positive Regulation Of Signal Transduction
Regulation Of Nitric Oxide Metabolic Process
Response To Nutrient Levels
Regulation Of Protein Modification Process
Protein Serine/threonine Kinase Binding
Cholesterol Transfer Activity
Regulation Of Defense Response
Intracellular Signal Transduction
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of Metabolic Process
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Signal Transduction
Regulation Of Macromolecule Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Metabolic Process
Cytosol
Nucleoplasm
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Negative Regulation Of Signaling
Protein Serine/threonine Kinase Activity
Negative Regulation Of Cell Communication
Ubiquitin Protein Ligase Binding
Negative Regulation Of Signal Transduction
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Gene Expression
Non-canonical NF-kappaB Signal Transduction
Regulation Of Primary Metabolic Process
Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Protein Kinase Activity
Regulation Of Apoptotic Process
Protein Modification Process
Protein Serine Kinase Activity
Immune System Process
Regulation Of Programmed Cell Death
Macromolecule Metabolic Process
Negative Regulation Of Intracellular Signal Transduction
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Immune System Process
Regulation Of Immune Response
Nucleus
Transferase Activity
Protein Metabolic Process
Kinase Activity
Regulation Of Innate Immune Response
Intracellular Signaling Cassette
Cytoplasm
Negative Regulation Of Programmed Cell Death
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Response To Stress
Cellular Response To Stress
Regulation Of Nucleobase-containing Compound Metabolic Process
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?