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AKT2 and PRKDC
Number of citations of the paper that reports this interaction (PubMedID
28319085
)
75
Data Source:
BioGRID
(genetic interference, enzymatic study)
AKT2
PRKDC
Description
AKT serine/threonine kinase 2
protein kinase, DNA-activated, catalytic subunit
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Early Endosome
Cytosol
Plasma Membrane
Cell Cortex
Membrane
Ruffle Membrane
Chromosome, Telomeric Region
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Nucleolus
Cytoplasm
Cytosol
DNA-dependent Protein Kinase-DNA Ligase 4 Complex
Membrane
Small-subunit Processome
Protein-containing Complex
Protein-DNA Complex
DNA-dependent Protein Kinase Complex
Nonhomologous End Joining Complex
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Metal Ion Binding
Protein Serine Kinase Activity
Molecular Function Activator Activity
Nucleotide Binding
DNA Binding
Double-stranded DNA Binding
RNA Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
DNA-dependent Protein Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Enzyme Binding
Protein Domain Specific Binding
U3 SnoRNA Binding
Histone H2AXS139 Kinase Activity
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Protein Serine Kinase Activity
Biological Process
Glycogen Metabolic Process
Glycogen Biosynthetic Process
Glucose Metabolic Process
Regulation Of Translation
Apoptotic Process
Signal Transduction
Insulin Receptor Signaling Pathway
Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane
Positive Regulation Of Glucose Metabolic Process
Regulation Of Cell Migration
Positive Regulation Of Cell Migration
Positive Regulation Of Fatty Acid Beta-oxidation
Peripheral Nervous System Myelin Maintenance
Cellular Response To Insulin Stimulus
Intracellular Signal Transduction
Protein Modification Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Fat Cell Differentiation
Positive Regulation Of Glycogen Biosynthetic Process
Positive Regulation Of D-glucose Import
Protein Stabilization
Regulation Of Cell Cycle
Mammary Gland Epithelial Cell Differentiation
Cellular Response To High Light Intensity
Protein Localization To Plasma Membrane
Positive Regulation Of Protein Targeting To Membrane
Retinal Rod Cell Apoptotic Process
Positive Regulation Of Cap-dependent Translational Initiation
Negative Regulation Of PERK-mediated Unfolded Protein Response
Positive Regulation Of Cell Motility
Maturation Of 5.8S RRNA
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
Somitogenesis
Negative Regulation Of Protein Phosphorylation
Activation Of Innate Immune Response
B Cell Lineage Commitment
Immature B Cell Differentiation
Pro-B Cell Differentiation
T Cell Lineage Commitment
Immune System Process
DNA Repair
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
DNA Recombination
Protein Phosphorylation
DNA Damage Response
Brain Development
Heart Development
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Ionizing Radiation
Response To Gamma Radiation
Telomere Capping
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Lymphocyte Differentiation
Replication Fork Processing
Mitotic G1 DNA Damage Checkpoint Signaling
Protein Destabilization
Cellular Response To Insulin Stimulus
T Cell Differentiation In Thymus
V(D)J Recombination
Immunoglobulin V(D)J Recombination
T Cell Receptor V(D)J Recombination
Small-subunit Processome Assembly
Ectopic Germ Cell Programmed Cell Death
Protein Modification Process
Ribosome Biogenesis
Regulation Of Circadian Rhythm
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Innate Immune Response
Positive Regulation Of Lymphocyte Differentiation
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Translation
Positive Regulation Of Transcription By RNA Polymerase II
Rhythmic Process
Regulation Of Smooth Muscle Cell Proliferation
Regulation Of Epithelial Cell Proliferation
Protein Localization To Chromatin
Regulation Of Cellular Response To Stress
Double-strand Break Repair Via Alternative Nonhomologous End Joining
DNA Repair-dependent Chromatin Remodeling
CGAS/STING Signaling Pathway
Negative Regulation Of CGAS/STING Signaling Pathway
Regulation Of Hematopoietic Stem Cell Differentiation
Positive Regulation Of Platelet Formation
Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways
Activation of BAD and translocation to mitochondria
PIP3 activates AKT signaling
PIP3 activates AKT signaling
Downregulation of ERBB2:ERBB3 signaling
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Activation of AKT2
PDE3B signalling
Inhibition of TSC complex formation by PKB
AKT phosphorylates targets in the cytosol
AKT phosphorylates targets in the cytosol
AKT phosphorylates targets in the nucleus
Negative regulation of the PI3K/AKT network
AKT-mediated inactivation of FOXO1A
Deactivation of the beta-catenin transactivating complex
CD28 dependent PI3K/Akt signaling
Co-inhibition by CTLA4
G beta:gamma signalling through PI3Kgamma
VEGFR2 mediated vascular permeability
TP53 Regulates Metabolic Genes
Constitutive Signaling by AKT1 E17K in Cancer
Regulation of TP53 Degradation
Regulation of TP53 Activity through Acetylation
Regulation of TP53 Activity through Association with Co-factors
Cyclin E associated events during G1/S transition
Cyclin A:Cdk2-associated events at S phase entry
RAB GEFs exchange GTP for GDP on RABs
RUNX2 regulates genes involved in cell migration
Regulation of PTEN stability and activity
FLT3 Signaling
Regulation of localization of FOXO transcription factors
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
KEAP1-NFE2L2 pathway
SARS-CoV-2 targets host intracellular signalling and regulatory pathways
Regulation of MITF-M-dependent genes involved in pigmentation
Cytosolic sensors of pathogen-associated DNA
IRF3-mediated induction of type I IFN
Nonhomologous End-Joining (NHEJ)
E3 ubiquitin ligases ubiquitinate target proteins
Drugs
N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide
4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE
ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE
(2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
Caffeine
SF1126
Diseases
Ovarian cancer
Familial partial lipodystrophy (FPL), including the following four diseases: Kobberling-type lipodystrophy (FPLD1); Dunnigan-type lipodystrophy (FPLD2); Dunnigan-like lipodystrophy (FPLD3); AKT2 associated lipodystrophy
GWAS
Birth weight (
31043758
)
Cerebrospinal fluid t-tau:AB1-42 ratio (
26252872
)
Cerebrospinal T-tau levels (
26252872
)
Diastolic blood pressure (
28739976
)
Lean body mass (
28552196
)
Lymphocyte count (
32888494
)
Adult body size (
32376654
)
Femur bone mineral density x serum urate levels interaction (
34046847
)
Hemoglobin (
32888494
)
Mean corpuscular hemoglobin (
32888494
)
Interacting Genes
43 interacting genes:
ABCG8
AKT1
AKT1S1
APOA1
APOB
APP
APPL1
BLVRA
CCL14
CDKN1A
CHUK
CLIP3
ESR1
FOXO4
FSHR
GSK3B
H3C1
HSP90AA1
MEOX2
MTCP1
NAMPT
PDPK1
PICK1
PIP5K1C
PLEKHO1
PNPLA3
POFUT1
POLR1B
PRKDC
RAB3D
REL
SH3RF1
SLC2A4
SORBS2
SORBS3
SPRR2A
STEAP4
TCL1A
TCL1B
TMED2
TRIB3
TSC2
XIAP
94 interacting genes:
ABL1
AKT1
AKT2
AP1B1
ATM
ATRIP
BRCA1
C1D
CASP3
CCNB1
CEBPA
CHEK1
CHEK2
CHUK
CIB1
CLK1
CTDP1
DCAF1
DCLRE1C
DUX4
E4F1
EIF2S2
EIF4EBP1
EP300
ERG
FH
GSK3A
GSK3B
GZMB
H1-1
H1-2
H2AX
HDAC3
HMGB1
HMGB2
HNRNPA1
HNRNPC
HOXC4
HSF1
HSP90AA1
IKBKB
IKBKG
ILF2
JUN
KAT2A
LIG4
LYN
MAPK8
MBP
MKNK1
MRE11
MTNR1B
NBN
NCF1
NCF2
NCF4
NCOA6
NEIL3
NR3C1
PARP1
PCNA
PDX1
PGR
PIDD1
POU2F1
PPP6R1
PPP6R3
PRKAG1
PRKCD
PTEN
RAD17
RASSF1
RNF10
RPA1
RPA2
SGO1
SP1
SRF
SUMO2
THRA
THRB
TP53
TREX1
TTC3
UBE2I
USF1
WRN
XPA
XRCC4
XRCC5
XRCC6
YWHAG
YWHAQ
ZBTB7A
Entrez ID
208
5591
HPRD ID
01262
02941
Ensembl ID
ENSG00000105221
ENSG00000253729
Uniprot IDs
B4DG79
P31751
P78527
PDB IDs
1GZK
1GZN
1GZO
1MRV
1MRY
1O6K
1O6L
1P6S
2JDO
2JDR
2UW9
2X39
2XH5
3D0E
3E87
3E88
3E8D
8Q61
9C1W
5LUQ
5W1R
5Y3R
6ZFP
6ZH2
6ZH4
6ZH6
6ZH8
6ZHA
6ZHE
7K0Y
7K10
7K11
7K19
7K1B
7K1J
7K1K
7K1N
7LT3
7NFC
7NFE
7OTM
7OTP
7OTV
7OTW
7OTY
7SGL
7SU3
7SUD
7TYR
7Z87
7Z88
8BH3
8BHV
8BHY
8BOT
8EZ9
8EZA
8EZB
8RD4
Enriched GO Terms of Interacting Partners
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Intracellular Signal Transduction
Signal Transduction
Regulation Of Intracellular Signal Transduction
Insulin Receptor Signaling Pathway
Cellular Response To Insulin Stimulus
Response To Hormone
Positive Regulation Of Protein Metabolic Process
Regulation Of Signal Transduction
Nitric-oxide Synthase Regulator Activity
Intracellular Signaling Cassette
Regulation Of Innate Immune Response
Cytosol
Regulation Of Cell Communication
Regulation Of Signaling
Cellular Response To Hormone Stimulus
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Positive Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Toll-like Receptor Signaling Pathway
Response To Insulin
Positive Regulation Of Nitric Oxide Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Signal Transduction
Cellular Response To Peptide Hormone Stimulus
Positive Regulation Of Gene Expression
Positive Regulation Of Metabolic Process
Chemical Homeostasis
Low-density Lipoprotein Particle
Regulation Of Vesicle-mediated Transport
Cellular Response To Oxygen-containing Compound
Cellular Response To Amyloid-beta
Homeostatic Process
Response To Peptide Hormone
Endocytic Vesicle Lumen
Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Protein Catabolic Process
Protein Kinase Binding
Regulation Of Nitric Oxide Biosynthetic Process
Very-low-density Lipoprotein Particle
Response To Amyloid-beta
Regulation Of Immune System Process
Response To Stress
Positive Regulation Of Signal Transduction
Regulation Of Nitric Oxide Metabolic Process
Response To Nutrient Levels
Regulation Of Protein Modification Process
Protein Serine/threonine Kinase Binding
Cholesterol Transfer Activity
Regulation Of Defense Response
Nucleus
Cellular Response To Stress
Nucleoplasm
Regulation Of Primary Metabolic Process
DNA Damage Response
Regulation Of Nucleobase-containing Compound Metabolic Process
DNA Repair
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Response To Stress
DNA Metabolic Process
Regulation Of Metabolic Process
Positive Regulation Of Metabolic Process
Damaged DNA Binding
Double-strand Break Repair
Nucleic Acid Metabolic Process
Regulation Of Gene Expression
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Macromolecule Metabolic Process
Regulation Of DNA Metabolic Process
DNA Binding
Negative Regulation Of Metabolic Process
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Intracellular Signal Transduction
Response To Radiation
Chromosome Organization
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of RNA Metabolic Process
DNA Recombination
Nucleobase-containing Compound Metabolic Process
Cellular Response To Radiation
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Response To Ionizing Radiation
Response To Hormone
Signal Transduction In Response To DNA Damage
Negative Regulation Of Macromolecule Biosynthetic Process
DNA Damage Checkpoint Signaling
Regulation Of Cellular Response To Stress
Negative Regulation Of Biosynthetic Process
Double-strand Break Repair Via Nonhomologous End Joining
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Cell Cycle
Enzyme Binding
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