IPO9 and MTNR1A

Number of citations of the paper that reports this interaction (PubMedID 26514267)
0

Data Source:
BioGRID (two hybrid)

		IPO9	MTNR1A
Description		importin 9	melatonin receptor 1A
Image
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Cytosol Membrane	Plasma Membrane Membrane Receptor Complex
	Molecular Function	Protein Binding Small GTPase Binding Histone Binding Nuclear Import Signal Receptor Activity Histone Chaperone Activity	G Protein-coupled Receptor Activity Protein Binding Melatonin Receptor Activity Hormone Binding
	Biological Process	Protein Import Into Nucleus Intracellular Protein Transport Proteasomal Protein Catabolic Process Protein Transport Proteasome Localization	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Mating Behavior Circadian Rhythm
Pathways			Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events
Drugs			Ramelteon Melatonin Resveratrol Agomelatine Tasimelteon
Diseases
GWAS		Adult body size ( 32376654) Myocardial infarction ( 33532862) Sleep duration (short sleep) ( 30846698) Waist circumference ( 31928498)	Depressive symptoms measurement (somatic complaints domain) ( 26997408) Job-related exhaustion in shift workers ( 28364478) Mild obesity-related type 2 diabetes ( 34737425) Obesity ( 21552555)
Interacting Genes		8 interacting genes: APP FBXO7 LINC01554 MTDH MTNR1A MTNR1B PPP2R1A RAN	160 interacting genes: ABHD14B ACTB ACTN1 AMOTL2 ANKRD12 ARHGAP28 ASAP3 ASCL1 ATIC ATP5MC3 BAG6 BAZ1A BAZ1B C10orf90 CALR CAND1 CANX CCDC167 CD99 CHD4 CIAO2B CIT CLASP1 CMIP CNP COG1 COL9A2 COMT COX11 CTNNA1 CTPS2 CUL3 CUL7 CYP27C1 CYSRT1 DDHD2 DDX52 DPM1 ECE1 ECE2 EEF1G EMC7 EMD ENO2 EPS15 EXOC1 F8A1 FAM241B FDXR FLNA FN1 FSTL1 GALNS GAPDH GATAD2B GBA2 GEMIN2 GFPT2 GNA11 GNA13 GNAI1 GNAI2 GNAI3 GNB1 GNB4 GPR50 H2AC6 HDAC10 HIVEP2 HMGN2 HMOX2 HNRNPA0 HNRNPH1 HSPA5 IPO9 IRS4 ITPR3 KLHL12 KLHL20 KLHL5 KPNB1 KRTAP1-3 KRTAP10-8 LAPTM4A LIPE LPP LRP3 LRRC59 MAMLD1 MCC MESD MMP2 MMS19 MPDZ MTNR1B MYO9A NAP1L1 NAP1L4 NAP1L5 NASP PAXIP1 PCDHB10 PDIA6 PEX14 PGRMC1 PKD1L2 PPP2R3C PRELID1 PSMD2 PSME4 PTPN13 PTPRD PTX3 RAB10 RAC1 RACK1 RAP1A RBM39 RGS12 RNF2 RNF41 RPL3 RTRAF SLC2A3 SLC30A1 SLC6A3 SLIT1 SNAPIN SOX11 SRI STXBP1 SUCLA2 SURF4 SVEP1 TLN1 TM9SF1 TMEM14A TMEM230 TMEM33 TMX2 TPP2 TRIP12 TUBB TVP23B UBA1 UBAP2L UBQLN1 UBR4 USP28 USP32 USP34 VAPB VARS1 WAPL WASHC4 YWHAB YWHAZ ZC3H11A ZDHHC16 ZNF460
Entrez ID		55705	4543
HPRD ID		17154	02812
Ensembl ID		ENSG00000198700	ENSG00000168412
Uniprot IDs		Q96P70	P48039
PDB IDs		6N1Z 8F7A	6ME2 6ME3 6ME4 6ME5 7DB6 7VGY 7VGZ
Enriched GO Terms of Interacting Partners?		Melatonin Receptor Activity Protein Heterodimerization Activity Mating Behavior Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Neuron Apoptotic Process Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Apoptotic Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Programmed Cell Death Reproductive Behavior G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Meiotic Spindle Elongation Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Regulation Of Apoptotic Signaling Pathway Acetylcholine Receptor Activator Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Lipoprotein Particle Regulation Of Protein Transport Positive Regulation Of Protein Import Regulation Of Intracellular Signal Transduction Regulation Of Meiotic Cell Cycle Process Involved In Oocyte Maturation RNA Nuclear Export Complex SnRNA Import Into Nucleus Pre-miRNA Export From Nucleus PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Nervous System Process Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Lewy Body Core Regulation Of Establishment Of Protein Localization Positive Regulation Of Catabolic Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Recycling Endosome Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling	Extracellular Exosome Cytosol Heterotrimeric G-protein Complex Focal Adhesion Melanosome Guanyl Nucleotide Binding Membrane G-protein Beta/gamma-subunit Complex Binding Cadherin Binding Homotypic Cell-cell Adhesion Regulation Of Organelle Organization Proteasomal Protein Catabolic Process G Protein Activity Regulation Of Cellular Component Organization Cytoplasm G Protein-coupled Receptor Binding Platelet Aggregation Diacylglycerol Lipase Activity Protein Binding Vinculin Binding Cellular Localization Protein Folding In Endoplasmic Reticulum Regulation Of Biological Quality Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process GTPase Activity Negative Regulation Of Vasoconstriction Proteolysis Neural Nucleus Development Establishment Of Protein Localization Protein Metabolic Process Negative Regulation Of Synapse Organization Cullin-RING Ubiquitin Ligase Complex Nucleoplasm Nucleosomal DNA Binding Protein-containing Complex Binding Melatonin Receptor Activity
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