RNF31 and SOCS3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		RNF31	SOCS3
Description		ring finger protein 31	suppressor of cytokine signaling 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex LUBAC Complex	Cytosol Cytoplasmic Side Of Plasma Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Protein Ligase Binding K48-linked Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Ubiquitin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity K63-linked Polyubiquitin Modification-dependent Protein Binding Linear Polyubiquitin Binding	Phosphotyrosine Residue Binding Protein Kinase Inhibitor Activity Cytokine Receptor Binding Protein Binding Protein Tyrosine Kinase Inhibitor Activity MiRNA Binding
	Biological Process	Protein Polyubiquitination Cell Surface Receptor Signaling Pathway Canonical NF-kappaB Signal Transduction Protein Ubiquitination CD40 Signaling Pathway Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Necroptotic Process Protein Linear Polyubiquitination Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Xenophagy	Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Signal Transduction Protein Ubiquitination Cytokine-mediated Signaling Pathway Cell Differentiation Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Differentiation Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Branching Involved In Labyrinthine Layer Morphogenesis Placenta Blood Vessel Development Interleukin-6-mediated Signaling Pathway T-helper 17 Cell Lineage Commitment Cellular Response To Interleukin-17 Cellular Response To Leukemia Inhibitory Factor
Pathways		TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway	Interleukin-6 signaling Signaling by Leptin Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling Regulation of IFNG signaling PTK6 Activates STAT3 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes Neddylation Interferon alpha/beta signaling Regulation of IFNA/IFNB signaling Signaling by CSF3 (G-CSF) Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling Growth hormone receptor signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Suicide behavior ( 26079190)	Asthma ( 32296059) Blood trace element (Se levels) ( 23720494) Creatine kinase levels ( 29403010)
Interacting Genes		60 interacting genes: ACVRL1 AGO2 ATG13 ATN1 ATXN1 ATXN7 AZI2 CASP1 CASP6 CASP8 CCDC24 CDC34 GFI1B GPX4 HDAC6 IKBKG KIF1A KRTAP9-2 MECOM NOS3 NR0B1 NR0B2 PINK1 PITX1 PRKCA PTEN RBCK1 RNF26 SEPTIN2 SHARPIN SMAD3 SNRPC SOCS3 STAT3 STK4 TLE5 TNF TRAF1 TRAF6 TRIM25 TSSC4 UBC UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2K UBE2L3 UBE2O UBE2Q1 UBE2Q2 UBE2R2 UBE2T UBE2W VASN VDAC1	66 interacting genes: ABL1 ACADVL APP AR BCL10 BIK BLK CAVIN1 CSF1R CSF3R CSNK1E CUEDC2 CXCR4 EGFR ELOB ELOC EPOR ERBB2 ERBB3 ERBB4 GAB1 GFRA1 GHR HIVEP1 IGF1R IL12RB2 IL2RB IL6ST INSR IRF7 IRS1 IRS2 JAK1 JAK2 JAK3 KIAA1958 KIT LEPR MAP1S MAPK11 MAPK6 MET MEX3C NFATC2 NME4 PDPK1 PIN1 PPP3CB PRLR PTK2 PTPN11 RASA1 RBMX RNF31 RNF7 RPL7A SH2D2A SOCS2 TES TFDP1 TFR2 TRDN TXK TXNDC11 YES1 YWHAQ
Entrez ID		55072	9021
HPRD ID		11516	05006
Ensembl ID		ENSG00000092098	ENSG00000184557
Uniprot IDs		Q96EP0	O14543 Q6FI39
PDB IDs		2CT7 4DBG 4JUY 4LJO 4LJP 4LJQ 4OWF 4OYJ 4OYK 4P09 4P0A 4P0B 5EDV 5LJN 5X0W 6GZY 6KC5 6KC6 6SC5 6SC6 6SC7 6SC8 6SC9 7TV4 7UY2 7UYJ 7UYK 7V8F 7V8G 8Z30 8Z36 9AZJ 9B0B 9B0Z 9B12
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Ubiquitin-protein Transferase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein K48-linked Ubiquitination Post-translational Protein Modification Protein Modification Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein K11-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Transferase Activity Proteolysis Protein Metabolic Process Macromolecule Catabolic Process ATP Binding Nucleotide Binding Regulation Of Canonical NF-kappaB Signal Transduction Nucleus Macromolecule Metabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Ubiquitin Protein Ligase Binding Regulation Of Signal Transduction Catabolic Process Positive Regulation Of Metabolic Process Regulation Of Signaling Regulation Of Cell Communication Cytosol Negative Regulation Of Signal Transduction Protein K63-linked Ubiquitination Protein-containing Complex Apoptotic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Programmed Cell Death Negative Regulation Of Macromolecule Biosynthetic Process Protein Binding Cell Death Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Nucleoplasm Positive Regulation Of Cell Communication	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Tyrosine Kinase Activity Receptor Complex Signal Transduction Protein Kinase Activity Kinase Activity Cytokine-mediated Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Phosphorylation Positive Regulation Of Cell Communication Cytokine Binding Phosphorylation Negative Regulation Of Programmed Cell Death Peptidyl-tyrosine Phosphorylation Intracellular Signal Transduction Positive Regulation Of Signaling Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Cell Population Proliferation Epidermal Growth Factor Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Cytokine Receptor Activity Growth Hormone Receptor Signaling Pathway Via JAK-STAT ERBB Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Cell Population Proliferation Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Metabolic Process Positive Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Process Negative Regulation Of Apoptotic Process External Side Of Plasma Membrane Regulation Of Programmed Cell Death Protein Modification Process Erythropoietin-mediated Signaling Pathway Developmental Process Positive Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Immune System Process Intracellular Signaling Cassette Cell Differentiation Positive Regulation Of Cell Motility Cellular Developmental Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Communication Positive Regulation Of Locomotion Protein Autophosphorylation
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