RNF31 and UBE2Q1

Number of citations of the paper that reports this interaction (PubMedID 30017913)
69

Data Source:
BioGRID (pull down)

		RNF31	UBE2Q1
Description		ring finger protein 31	ubiquitin conjugating enzyme E2 Q1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex LUBAC Complex	Nucleus Cytoplasm Cytosol Filopodium Cell Projection
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Protein Ligase Binding K48-linked Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Ubiquitin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity K63-linked Polyubiquitin Modification-dependent Protein Binding Linear Polyubiquitin Binding	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Protein Polyubiquitination Cell Surface Receptor Signaling Pathway Canonical NF-kappaB Signal Transduction Protein Ubiquitination CD40 Signaling Pathway Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Necroptotic Process Protein Linear Polyubiquitination Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Xenophagy	Protein Polyubiquitination Suckling Behavior Embryo Implantation Mating Behavior Fertilization Protein Ubiquitination Reproductive System Development Prolactin Secretion
Pathways		TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Suicide behavior ( 26079190)	Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798)
Interacting Genes		60 interacting genes: ACVRL1 AGO2 ATG13 ATN1 ATXN1 ATXN7 AZI2 CASP1 CASP6 CASP8 CCDC24 CDC34 GFI1B GPX4 HDAC6 IKBKG KIF1A KRTAP9-2 MECOM NOS3 NR0B1 NR0B2 PINK1 PITX1 PRKCA PTEN RBCK1 RNF26 SEPTIN2 SHARPIN SMAD3 SNRPC SOCS3 STAT3 STK4 TLE5 TNF TRAF1 TRAF6 TRIM25 TSSC4 UBC UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2K UBE2L3 UBE2O UBE2Q1 UBE2Q2 UBE2R2 UBE2T UBE2W VASN VDAC1	13 interacting genes: ECPAS FHL3 IRF2BPL ITCH LMNA MDM2 OGT RNF26 RNF31 RNF7 STUB1 TP53 UBC
Entrez ID		55072	55585
HPRD ID		11516	15601
Ensembl ID		ENSG00000092098	ENSG00000160714
Uniprot IDs		Q96EP0	Q7Z7E8
PDB IDs		2CT7 4DBG 4JUY 4LJO 4LJP 4LJQ 4OWF 4OYJ 4OYK 4P09 4P0A 4P0B 5EDV 5LJN 5X0W 6GZY 6KC5 6KC6 6SC5 6SC6 6SC7 6SC8 6SC9 7TV4 7UY2 7UYJ 7UYK 7V8F 7V8G 8Z30 8Z36 9AZJ 9B0B 9B0Z 9B12	2QGX
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Ubiquitin-protein Transferase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein K48-linked Ubiquitination Post-translational Protein Modification Protein Modification Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein K11-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Transferase Activity Proteolysis Protein Metabolic Process Macromolecule Catabolic Process ATP Binding Nucleotide Binding Regulation Of Canonical NF-kappaB Signal Transduction Nucleus Macromolecule Metabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Ubiquitin Protein Ligase Binding Regulation Of Signal Transduction Catabolic Process Positive Regulation Of Metabolic Process Regulation Of Signaling Regulation Of Cell Communication Cytosol Negative Regulation Of Signal Transduction Protein K63-linked Ubiquitination Protein-containing Complex Apoptotic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Programmed Cell Death Negative Regulation Of Macromolecule Biosynthetic Process Protein Binding Cell Death Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Nucleoplasm Positive Regulation Of Cell Communication	Protein Ubiquitination Ubiquitin Protein Ligase Activity Protein Modification By Small Protein Conjugation Regulation Of Programmed Necrotic Cell Death Post-translational Protein Modification Protein Polyubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification Process Proteolysis Negative Regulation Of Signal Transduction Ubiquitin Protein Ligase Binding Modification-dependent Protein Catabolic Process Cellular Response To Actinomycin D Catabolic Process Regulation Of Necroptotic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Negative Regulation Of Cell Communication Negative Regulation Of Signaling NEDD8 Ligase Activity Response To Actinomycin D Protein Metabolic Process Macromolecule Catabolic Process Cellular Response To Oxygen Levels Cellular Response To UV-C Transferase Activity Proteasomal Protein Catabolic Process Protein Autoubiquitination Response To Endoplasmic Reticulum Stress Cellular Response To Antibiotic Negative Regulation Of Programmed Cell Death Ubiquitin-protein Transferase Activity Regulation Of Programmed Cell Death Ubiquitin-dependent Protein Catabolic Process Macromolecule Metabolic Process Response To UV-C Response To Hypoxia Nucleoplasm Protein Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Ubiquitin-ubiquitin Ligase Activity Response To Decreased Oxygen Levels Negative Regulation Of Defense Response To Virus Response To Stress Response To Oxygen Levels Negative Regulation Of Cellular Component Organization Regulation Of Protein Stability Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Regulation Of Protein Catabolic Process
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