RNF31 and RBCK1

Number of citations of the paper that reports this interaction (PubMedID 17006537)
43

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo, in vitro)

		RNF31	RBCK1
Description		ring finger protein 31	RANBP2-type and C3HC4-type zinc finger containing 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex LUBAC Complex	Cytosol LUBAC Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Protein Ligase Binding K48-linked Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Ubiquitin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity K63-linked Polyubiquitin Modification-dependent Protein Binding Linear Polyubiquitin Binding	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Ubiquitin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Protein Sequestering Activity Ubiquitin Ligase Activator Activity
	Biological Process	Protein Polyubiquitination Cell Surface Receptor Signaling Pathway Canonical NF-kappaB Signal Transduction Protein Ubiquitination CD40 Signaling Pathway Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Necroptotic Process Protein Linear Polyubiquitination Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Xenophagy	Protein Polyubiquitination Positive Regulation Of Macromolecule Metabolic Process Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Bacterium Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA-templated Transcription T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Necroptotic Process Regulation Of Primary Metabolic Process Protein Linear Polyubiquitination Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway	TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Suicide behavior ( 26079190)	Femur bone mineral density x serum urate levels interaction ( 34046847) Night sleep phenotypes ( 27126917)
Interacting Genes		60 interacting genes: ACVRL1 AGO2 ATG13 ATN1 ATXN1 ATXN7 AZI2 CASP1 CASP6 CASP8 CCDC24 CDC34 GFI1B GPX4 HDAC6 IKBKG KIF1A KRTAP9-2 MECOM NOS3 NR0B1 NR0B2 PINK1 PITX1 PRKCA PTEN RBCK1 RNF26 SEPTIN2 SHARPIN SMAD3 SNRPC SOCS3 STAT3 STK4 TLE5 TNF TRAF1 TRAF6 TRIM25 TSSC4 UBC UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2K UBE2L3 UBE2O UBE2Q1 UBE2Q2 UBE2R2 UBE2T UBE2W VASN VDAC1	71 interacting genes: ANKRD35 ANTXR1 APP ARNT2 BACH1 CREB5 CREBBP ENKD1 GLYCTK HGS HOXA1 HOXC8 IL16 IREB2 KANK2 LNX1 MAP3K1 MAPKBP1 MKRN2 MTSS1 NAA10 NDUFAF3 NEDD4 NR1I2 OTUB2 OTUD6A PAN2 PCGF2 PRKCA PRKN PSMA1 PSMD4 RELA RIPPLY3 RNF181 RNF26 RNF31 SHARPIN SMURF1 SOCS6 SYCE1 TNF TNFAIP3 TP53 TRAF1 TRIM25 TRIM65 TRIML1 TSSK3 TTC23 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2G1 UBE2K UBE2L3 UBE2L6 UBE2N UBE2S UBE2U UCHL5 UHRF2 USP15 USP2 USP21 USP32 USP49 USP7 ZNF414
Entrez ID		55072	10616
HPRD ID		11516	16643
Ensembl ID		ENSG00000092098	ENSG00000125826
Uniprot IDs		Q96EP0	A0A8V8TMZ2 A6PVJ6 Q9BYM8
PDB IDs		2CT7 4DBG 4JUY 4LJO 4LJP 4LJQ 4OWF 4OYJ 4OYK 4P09 4P0A 4P0B 5EDV 5LJN 5X0W 6GZY 6KC5 6KC6 6SC5 6SC6 6SC7 6SC8 6SC9 7TV4 7UY2 7UYJ 7UYK 7V8F 7V8G 8Z30 8Z36 9AZJ 9B0B 9B0Z 9B12	2CRC 2LGY 4DBG 7V8E 7YUI 7YUJ 8BVL 8EAZ 8K6Q 9EGV 9EGW
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Ubiquitin-protein Transferase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein K48-linked Ubiquitination Post-translational Protein Modification Protein Modification Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein K11-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Transferase Activity Proteolysis Protein Metabolic Process Macromolecule Catabolic Process ATP Binding Nucleotide Binding Regulation Of Canonical NF-kappaB Signal Transduction Nucleus Macromolecule Metabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Ubiquitin Protein Ligase Binding Regulation Of Signal Transduction Catabolic Process Positive Regulation Of Metabolic Process Regulation Of Signaling Regulation Of Cell Communication Cytosol Negative Regulation Of Signal Transduction Protein K63-linked Ubiquitination Protein-containing Complex Apoptotic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Programmed Cell Death Negative Regulation Of Macromolecule Biosynthetic Process Protein Binding Cell Death Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Nucleoplasm Positive Regulation Of Cell Communication	Post-translational Protein Modification Protein Modification Process Protein Ubiquitination Ubiquitin-protein Transferase Activity Protein Polyubiquitination Protein Modification By Small Protein Conjugation Proteolysis Protein Metabolic Process Ubiquitin Conjugating Enzyme Activity Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Protein Deubiquitination Protein Modification By Small Protein Removal Cysteine-type Deubiquitinase Activity Macromolecule Metabolic Process Transferase Activity Catabolic Process Ubiquitin Protein Ligase Activity Protein K48-linked Ubiquitination Cysteine-type Peptidase Activity Ubiquitin Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin-like Protein Transferase Activity Protein K11-linked Ubiquitination Protein K63-linked Ubiquitination Protein Catabolic Process Ubiquitin Protein Ligase Binding Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Signal Transduction Regulation Of RNA Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Defense Response Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Zinc Ion Binding Regulation Of Signaling Regulation Of Cell Communication Regulation Of DNA-templated Transcription Free Ubiquitin Chain Polymerization Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Protein Catabolic Process
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