RNF31 and PITX1

Number of citations of the paper that reports this interaction (PMID 24722188)
1

Data Source:
BioGRID (two hybrid)

		RNF31	PITX1
Gene Name		ring finger protein 31	paired-like homeodomain 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex LUBAC Complex	Nucleus Transcription Factor Complex Nucleolus Cytoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Binding Ubiquitin Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription
	Biological Process	Protein Polyubiquitination CD40 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Linear Polyubiquitination	Skeletal System Development Transcription, DNA-templated Anatomical Structure Morphogenesis Branchiomeric Skeletal Muscle Development Pituitary Gland Development Embryonic Hindlimb Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Myoblast Fate Commitment Cartilage Development
Pathways
Drugs
Diseases
GWAS			Bulimia nervosa ( 23568457) Colorectal cancer ( 23263487) Height ( 20881960 23563607 18391951) Immune response to anthrax vaccine ( 22658931) Testicular germ cell tumor ( 23666240)
Protein-Protein Interactions		27 interactors: AES ATN1 ATXN1 ATXN7 AZI2 CCDC24 GFI1B IKBKG KIF1A KRTAP9-2 NOS3 NR0B1 NR0B2 PITX1 PRKCA RBCK1 SMAD3 SNRPC SOCS3 TRAF1 TRIM25 TSSC4 UBC UBE2D1 UBE2D3 VASN VCP	24 interactors: ALG13 C1orf94 CDX4 DVL3 EGR1 HGS IPO13 LZTS2 MAGED1 MGAT5B NEUROD1 NR5A1 PLSCR1 POU1F1 PRR20A RBPMS RFX6 RHOXF2 RNF31 SMARCA2 SPAG8 TRIM23 UPF2 ZBTB32
Entrez ID		55072	5307
HPRD ID		11516	03688
Ensembl ID		ENSG00000092098	ENSG00000069011
Uniprot IDs		Q96EP0	P78337
PDB IDs		2CT7 4DBG 4JUY
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Signal Transduction Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Signaling Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Signaling Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of RNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Signal Transduction Negative Regulation Of Nucleic Acid-templated Transcription Transcription, DNA-templated Negative Regulation Of RNA Biosynthetic Process DNA-templated Transcription, Initiation RNA Biosynthetic Process Gene Expression Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Response To Abiotic Stimulus Regulation Of Apoptotic Process MyD88-independent Toll-like Receptor Signaling Pathway Cellular Response To Organic Substance Toll-like Receptor 3 Signaling Pathway Regulation Of Cell Death Protein Ubiquitination Signaling Toll-like Receptor 4 Signaling Pathway Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Response To Organic Substance Protein Modification By Small Protein Conjugation Cell Communication Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Immune System Process Apoptotic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels	Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Nuclear Transport Regulation Of Metabolic Process Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process RNA Biosynthetic Process Pancreatic A Cell Differentiation Macromolecule Biosynthetic Process Regulation Of Signaling RNA Metabolic Process Regulation Of Signal Transduction Gene Expression Nucleocytoplasmic Transport Organ Development Negative Regulation Of JAK-STAT Cascade Enteroendocrine Cell Differentiation Negative Regulation Of Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Transcription, DNA-templated Cytoplasmic Transport Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process System Development Positive Regulation Of Kidney Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Multicellular Organismal Aging Negative Regulation Of Wnt Signaling Pathway Glandular Epithelial Cell Differentiation Negative Regulation Of Gene Expression Pancreatic Epsilon Cell Differentiation Positive Regulation Of Glomerular Metanephric Mesangial Cell Proliferation Pancreatic D Cell Differentiation Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Canonical Wnt Signaling Pathway
Tagcloud ?		adjuvant antiestrogens arise aromatase associates atypical confirms cytosol decreases diagnostics e3 eralpha establishes estrogen facilitates initially insights ligase mono occupied promoters reduces stability stabilizes stabilizing therapeutics ubiquitin ubiquitination utmost	17beta 3x0 3x20 antide buserelin diarylpropionitrile dpn egr1 erb esr1 esr2 gnrh gnrhr gonadotroph lhb microinjected microinjections oestradiol oestrogenic orchestrated ovariectomised pituitaries ppt propyl pulsatile pulses pyrazole stimulations triol
Tagcloud (Difference) ?		adjuvant antiestrogens arise aromatase associates atypical confirms cytosol decreases diagnostics e3 eralpha establishes estrogen facilitates initially insights ligase mono occupied promoters reduces stability stabilizes stabilizing therapeutics ubiquitin ubiquitination utmost	17beta 3x0 3x20 antide buserelin diarylpropionitrile dpn egr1 erb esr1 esr2 gnrh gnrhr gonadotroph lhb microinjected microinjections oestradiol oestrogenic orchestrated ovariectomised pituitaries ppt propyl pulsatile pulses pyrazole stimulations triol
Tagcloud (Intersection) ?