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GNL3L and ALAS1
Number of citations of the paper that reports this interaction (PubMedID
25416956
)
56
Data Source:
BioGRID
(two hybrid)
GNL3L
ALAS1
Description
G protein nucleolar 3 like
5'-aminolevulinate synthase 1
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Telomerase Holoenzyme Complex
Nucleolus
Cytosol
Membrane
Nucleoplasm
Mitochondrion
Mitochondrial Inner Membrane
Mitochondrial Matrix
Cytosol
Membrane
Molecular Function
Nucleotide Binding
RNA Binding
Protein Binding
GTP Binding
5-aminolevulinate Synthase Activity
Protein Binding
Transferase Activity
Acyltransferase Activity
Pyridoxal Phosphate Binding
Identical Protein Binding
Biological Process
Positive Regulation Of Protein-containing Complex Assembly
Negative Regulation Of Protein Ubiquitination
Regulation Of Protein Stability
Negative Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of Protein Sumoylation
Ribosome Biogenesis
Positive Regulation Of Protein Localization To Chromosome, Telomeric Region
Response To Hypoxia
Porphyrin-containing Compound Metabolic Process
Protoporphyrinogen IX Biosynthetic Process
Heme Biosynthetic Process
Heme A Biosynthetic Process
Heme B Biosynthetic Process
Response To Xenobiotic Stimulus
Response To Herbicide
Response To Nickel Cation
Response To Nutrient Levels
Response To Cobalt Ion
Cellular Response To Insulin Stimulus
Tetrapyrrole Biosynthetic Process
Response To Gonadotropin
Hemoglobin Biosynthetic Process
Response To Ethanol
Heme O Biosynthetic Process
Erythrocyte Development
Response To CAMP
Response To Platinum Ion
Response To Bile Acid
Pathways
Heme biosynthesis
PPARA activates gene expression
Transcriptional activation of mitochondrial biogenesis
Mitochondrial protein degradation
Drugs
Pyridoxal phosphate
Pyridoxal phosphate
Glycine
Diseases
GWAS
Prostate cancer (
31562322
)
Autism spectrum disorder or schizophrenia (
28540026
)
Bipolar disorder (
21926972
)
Parkinson's disease (
28892059
)
Schizophrenia (
23974872
)
Interacting Genes
16 interacting genes:
ADRB2
ALAS1
CTBP1
DYNLL1
GOLGA2
HMBOX1
HSF2BP
KPNA1
LDOC1
LZTS2
MTUS2
PRKAR1B
ROPN1
TERF1
TFIP11
TRIM54
54 interacting genes:
BCL7A
C2orf42
C8orf33
CAP2
CCHCR1
CDC73
CDK5
CDKN1A
CERK
COBL
EP400
FBXL8
FXR1
GNL3L
GRXCR1
HSBP1L1
JRK
KIF9
KLHL35
LONRF1
LRRC45
MTFR2
MTSS2
NUDT3
OXTR
PIBF1
PIK3CB
PLAU
POLDIP2
PPL
RAP1B
RNF168
RTL8B
SH2D4A
SNRPB2
SNX20
STAMBP
SUMO2
TCEA2
TEKT4
TK1
TMSB10
TMSB4X
TMSB4XP1
TMSB4XP2
TMSB4XP6
TTC23
USP20
UTP14C
WIPF1
ZFYVE26
ZMAT1
ZNF175
ZNF564
Entrez ID
54552
211
HPRD ID
06514
00505
Ensembl ID
ENSG00000130119
ENSG00000023330
Uniprot IDs
Q05DU1
Q9NVN8
B4DVA0
P13196
Q5JAM2
PDB IDs
Enriched GO Terms of Interacting Partners
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Microtubule
Double-stranded Telomeric DNA Binding
Identical Protein Binding
Microtubule Binding
Telomere Maintenance
Mitotic Spindle
Negative Regulation Of DNA Metabolic Process
Negative Regulation Of DNA Replication
RNA-templated DNA Biosynthetic Process
Telomere Maintenance Via Telomerase
Telomere Organization
Telomeric DNA Binding
Telomere Maintenance Via Telomere Lengthening
Positive Regulation Of Excitatory Postsynaptic Potential
Regulation Of CAMP/PKA Signal Transduction
Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine
Modulation Of Excitatory Postsynaptic Potential
Positive Regulation Of Mini Excitatory Postsynaptic Potential
Organelle Organization
Reproductive Process
Microtubule-based Process
Regulation Of DNA Metabolic Process
Negative Regulation Of Establishment Of Protein Localization To Telomere
Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere
DNA Metabolic Process
Negative Regulation Of Establishment Of RNA Localization To Telomere
Positive Regulation Of Shelterin Complex Assembly
Chromosome, Telomeric Region
Microtubule Associated Complex
Telomere-telomerase Complex Assembly
Primary Ureteric Bud Growth
Cytoplasm
Microtubule Cytoskeleton
Beta2-adrenergic Receptor Activity
Establishment Of Localization In Cell
Developmental Process
5-aminolevulinate Synthase Activity
Response To Nickel Cation
Cytoskeleton
Negative Regulation Of Telomeric D-loop Disassembly
Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication
Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing
Spliceosomal Complex Disassembly
Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure
Beta-adrenergic Receptor Activity
Satellite Cell Activation Involved In Skeletal Muscle Regeneration
Deoxyribonuclease Inhibitor Activity
Centrosome
Regulation Of DNA Strand Resection Involved In Replication Fork Processing
Nitric-oxide Synthase Inhibitor Activity
Actin Monomer Binding
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