GNL3L and HMBOX1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GNL3L	HMBOX1
Description		G protein nucleolar 3 like	homeobox containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Telomerase Holoenzyme Complex Nucleolus Cytosol Membrane	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Cytosol Cajal Body Nuclear Body PML Body
	Molecular Function	Nucleotide Binding RNA Binding Protein Binding GTP Binding	DNA Binding Double-stranded Telomeric DNA Binding Protein Binding Telomeric DNA Binding Identical Protein Binding Sequence-specific DNA Binding Protein-containing Complex Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Protein Ubiquitination Regulation Of Protein Stability Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Protein Sumoylation Ribosome Biogenesis Positive Regulation Of Protein Localization To Chromosome, Telomeric Region	Negative Regulation Of Transcription By RNA Polymerase II Telomere Maintenance Via Telomerase Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Telomere-telomerase Complex Assembly
Pathways
Drugs
Diseases
GWAS		Prostate cancer ( 31562322)	Obesity-related traits ( 23251661)
Interacting Genes		16 interacting genes: ADRB2 ALAS1 CTBP1 DYNLL1 GOLGA2 HMBOX1 HSF2BP KPNA1 LDOC1 LZTS2 MTUS2 PRKAR1B ROPN1 TERF1 TFIP11 TRIM54	98 interacting genes: ABITRAM AEBP2 ANKRD36 APP ATP5PO BAZ2B BEND7 BRD1 BYSL C8orf33 CARD9 CBX8 CCDC187 CCNG1 CDC7 CDCA8 CDK18 DAB1 DNTTIP1 DYNLL1 ENKD1 ENTPD2 FAM13C FAM161A FAM217B FAM74A4 FAM90A1 FARS2 FGF11 FNDC11 FRMD6 FXR2 GAS2L2 GNL3L GSC2 INO80B IPO13 KAT5 KIF9 LMO1 LMO3 LNX1 MAGEH1 MCRS1 MEOX1 MEOX2 MFAP1 MORF4L1 MORF4L2 MRPL11 MRPL28 PAX5 PAX6 PIAS2 PICK1 PIP4K2B PKD1P1 POLDIP3 POLL PRKAA1 PRKAA2 PRPF18 RBMY2FP RCOR3 REEP6 RPL9 RPS25 SAP30L SCNM1 SDCBP SFR1 SH2D4A SNRPB2 SNW1 SYT6 TBP TCEA2 TCEANC TSGA10IP TUFM U2AF2 UBA6 UBE2I UBE2Z VAX1 VPS72 WT1 ZBTB24 ZBTB26 ZFYVE26 ZMAT2 ZMYM5 ZNF250 ZNF337 ZNF417 ZNF581 ZNF587 ZNF688
Entrez ID		54552	79618
HPRD ID		06514	07964
Ensembl ID		ENSG00000130119	ENSG00000147421
Uniprot IDs		Q05DU1 Q9NVN8	Q6NT76
PDB IDs			2CUF 4J19
Enriched GO Terms of Interacting Partners?		Microtubule Double-stranded Telomeric DNA Binding Identical Protein Binding Microtubule Binding Telomere Maintenance Mitotic Spindle Negative Regulation Of DNA Metabolic Process Negative Regulation Of DNA Replication RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomerase Telomere Organization Telomeric DNA Binding Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of CAMP/PKA Signal Transduction Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Mini Excitatory Postsynaptic Potential Organelle Organization Reproductive Process Microtubule-based Process Regulation Of DNA Metabolic Process Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere DNA Metabolic Process Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Chromosome, Telomeric Region Microtubule Associated Complex Telomere-telomerase Complex Assembly Primary Ureteric Bud Growth Cytoplasm Microtubule Cytoskeleton Beta2-adrenergic Receptor Activity Establishment Of Localization In Cell Developmental Process 5-aminolevulinate Synthase Activity Response To Nickel Cation Cytoskeleton Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Spliceosomal Complex Disassembly Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Beta-adrenergic Receptor Activity Satellite Cell Activation Involved In Skeletal Muscle Regeneration Deoxyribonuclease Inhibitor Activity Centrosome Regulation Of DNA Strand Resection Involved In Replication Fork Processing Nitric-oxide Synthase Inhibitor Activity	Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nuclear Speck Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Lipid Droplet Disassembly Protein Binding Positive Regulation Of DNA Repair NuA4 Histone Acetyltransferase Complex Regulation Of Macromolecule Biosynthetic Process Phosphatidylethanolamine Biosynthetic Process DNA Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Nucleic Acid Metabolic Process Regulation Of Macromolecule Metabolic Process DNA Recombination Chromatin Organization Spliceosomal Complex Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Double-strand Break Repair Via Homologous Recombination Recombinational Repair Cellular Response To Glucose Starvation Protein Localization To Lipid Droplet Positive Regulation Of DNA Metabolic Process Phosphatidylcholine Biosynthetic Process Positive Regulation Of Glycolytic Process Somite Specification Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of DNA Repair Negative Regulation Of Tubulin Deacetylation Negative Regulation Of Hepatocyte Apoptotic Process AMP-activated Protein Kinase Activity Phosphatidylethanolamine Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA Metabolic Process Regulation Of Tubulin Deacetylation Astrocyte Differentiation
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