PGK1 and YWHAQ

Number of citations of the paper that reports this interaction (PubMedID 26344197)
49

Data Source:
BioGRID (biochemical, pull down)

		PGK1	YWHAQ
Description		phosphoglycerate kinase 1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
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GO Annotations	Cellular Component	Extracellular Space Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Membrane Membrane Raft Extracellular Exosome	Nucleus Cytoplasm Cytosol Focal Adhesion Membrane Protein-containing Complex Synapse Extracellular Exosome
	Molecular Function	Nucleotide Binding Phosphoglycerate Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity ADP Binding Transmembrane Transporter Binding Metal Ion Binding Protein-disulfide Reductase [NAD(P)H] Activity Protein Serine Kinase Activity	Protein Binding Protein Domain Specific Binding Identical Protein Binding Transmembrane Transporter Binding 14-3-3 Protein Binding
	Biological Process	Gluconeogenesis Glycolytic Process Negative Regulation Of Angiogenesis Epithelial Cell Differentiation Plasminogen Activation Canonical Glycolysis Cellular Response To Hypoxia Negative Regulation Of Pyruvate Decarboxylation To Acetyl-CoA	Protein Targeting Signal Transduction Small GTPase-mediated Signal Transduction Intracellular Protein Localization Substantia Nigra Development Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of DNA-templated Transcription
Pathways		Glycolysis Gluconeogenesis Manipulation of host energy metabolism	Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Regulation of localization of FOXO transcription factors SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways
Drugs		Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate 3-phospho-D-glyceric acid Copper Artenimol	Phenethyl Isothiocyanate
Diseases		Anemia due to disorders of glycolytic enzymes, including: Hexokinase (HK) deficiency; Phosphoglycerate kinase 1 (PGK1) deficiency; Triose-phosphate isomerase (TPI) deficiency; Glucose phosphate isomerase (GPI) deficiency; Bisphosphoglycerate mutase (BPGM) deficiency
GWAS		Mean platelet volume ( 32888494)	Heart rate variability traits ( 22174390) Non-response to selective serotonin reuptake inhibitors and depression ( 27622933)
Interacting Genes		22 interacting genes: AR BECN1 CDC7 CEBPA CLIC6 CSNK2A1 DISC1 FNDC3B GAPDH HIF1A HSPH1 LINC01554 NAA10 OGT PCNA RHOU SUMO2 SUMO4 SUPT5H TUBA1A UBE3A YWHAQ	216 interacting genes: AARS2 ABL1 ACSL4 ADRB2 AGTR1 AHCY AKT1S1 ANXA1 ANXA2 AR ARHGAP10 ARHGEF16 ATP5F1A BAD BAX BCAP31 BCR BRAF CABIN1 CAPN3 CBL CBLL1 CCDC125 CDC25A CDC25B CDC25C CDC5L CDK11B CDK14 CDK16 CDKN1A CDKN1B CFL1 CHAF1A CKM CLTC COPS4 CSE1L CSNK1A1 CSNK2A1 CTPS1 DAB2IP DCPS DDX1 DDX3X DHX9 DISC1 DNMT1 DYNC1H1 E2F1 EFNB1 EGFR EIF4A3 ENO1 EPB41 EPB41L1 EPB41L3 ESR1 ESR2 FASN FBLN1 FGR FSCN1 FSHR FXYD1 GAPDH GCN1 H2BC8 H4C14 HADHA HAT1 HAX1 HDAC7 HNRNPC HNRNPH1 HSPA1A HSPA8 HSPB1 HUS1 IARS2 ING1 ITCH ITGB4 KANK1 KCNK15 KCNK3 KCNK9 KIF5B KLC2 KLC3 KRT1 KRT9 LARP1 LARS2 LDHA LIMA1 LMNA LMNB1 LYST MAGOH MAP3K3 MAP3K5 MCM3 MDM4 MED1 MEF2D MPL MPRIP MRPS27 MST1R MTNR1B MTOR MYCBP2 NADK NCL NCOA1 NCOA3 NDE1 NEDD4L NFATC1 NFATC2 NFATC4 NFKB1 NIF3L1 NME7 NOLC1 NUMA1 PABPN1 PANK1 PDCD6 PDE3A PDE3B PDE4B PDK1 PDPK1 PDXK PFKFB2 PFKL PFN1 PGK1 PHLDB2 PI4KB PIK3C3 PIK3CB PKM PRDX1 PRKCQ PRKCZ PRKD1 PRKDC PRMT5 PSME3 RAI14 RCOR3 REM1 RFC1 RGS3 RGS7 RIPK2 RNASE2 RPL10A RPL15 RPL19 RPL7 RPLP0 RPLP2 RPS3 RUVBL2 SAMSN1 SH3BP2 SKIC8 SLC27A2 SLC8A1 SLC8A2 SLC8A3 SMAD9 SNRPE SOCS3 SPR SPTA1 SPTB SRSF3 SSBP1 SSX2IP SUMO2 TCP1 TERT THRA TLN1 TNF TNFAIP3 TPI1 TPR TRAF6 TRIM25 TRIM28 TRIM42 TSC1 TSC2 TUBA1A TUBA3C TUBB UBQLN4 UCP2 UCP3 ULK4 USP8 VARS1 WDR77 WTAP WWC2 WWP1 YAP1 YWHAG ZC3H13 ZHX2
Entrez ID		5230	10971
HPRD ID		02412	00886
Ensembl ID		ENSG00000102144	ENSG00000134308
Uniprot IDs		P00558 V9HWF4	P27348
PDB IDs		2WZB 2WZC 2WZD 2X13 2X14 2X15 2XE6 2XE7 2XE8 2Y3I 2YBE 2ZGV 3C39 3C3A 3C3B 3C3C 3ZOZ 4AXX 4O33 5M1R 5M3U 5M6Z 5MXM 5NP8 5O7D 8YHP	2BTP 5IQP 6BCR 6BD2 6BQT 6KZG 6KZH
Enriched GO Terms of Interacting Partners?		Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Catabolic Process Regulation Of Macroautophagy Positive Regulation Of Macroautophagy Positive Regulation Of Metabolic Process Rhythmic Process Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Protein-containing Complex Response To Metal Ion Negative Regulation Of Nucleobase-containing Compound Metabolic Process Prostate Gland Growth Positive Regulation Of Autophagy Regulation Of Autophagy Organelle Organization Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Nucleus Response To Steroid Hormone Cellular Response To Oxidative Stress Negative Regulation Of Macromolecule Biosynthetic Process Response To Ketone TOR Signaling Protein Tag Activity Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Protein Localization To Vacuole Negative Regulation Of Metabolic Process Response To L-glutamate Regulation Of Metabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Androgen Receptor Signaling Pathway Sin3-type Complex Cellular Response To Chemical Stress Neuron Apoptotic Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Epithelial Cell Maturation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Embryonic Placenta Development Regulation Of Macromolecule Metabolic Process Ubiquitin-like Protein Ligase Binding Positive Regulation Of Signal Transduction Positive Regulation Of Neuroblast Proliferation	Cytosol Cytoplasm Regulation Of Signaling Regulation Of Cell Communication Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Protein Metabolic Process ATP Binding Regulation Of Cellular Component Organization Regulation Of Primary Metabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Positive Regulation Of Metabolic Process Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Metabolic Process Nucleus Cadherin Binding Kinase Activity Negative Regulation Of Programmed Cell Death Regulation Of Developmental Process Nucleobase-containing Compound Metabolic Process Cellular Response To Stress Nucleotide Binding Regulation Of Biological Quality Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Metabolic Process Cell Cortex Cellular Response To Oxygen-containing Compound Response To Stress Protein-containing Complex Glucose Catabolic Process Organelle Organization Positive Regulation Of Multicellular Organismal Process Macromolecule Metabolic Process ADP Metabolic Process RNA Binding Cellular Response To Lipid Positive Regulation Of Cell Communication Positive Regulation Of Signaling Extracellular Exosome Regulation Of Organelle Organization Positive Regulation Of Cell Population Proliferation Glycolytic Process Cellular Response To Hormone Stimulus
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