PGK1 and DISC1

Number of citations of the paper that reports this interaction (PMID 17043677)
96

Data Source:
BioGRID (two hybrid)

		PGK1	DISC1
Gene Name		phosphoglycerate kinase 1	disrupted in schizophrenia 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Membrane Extracellular Vesicular Exosome	Mitochondrion Centrosome Microtubule Postsynaptic Density Cell Junction Ciliary Basal Body Postsynaptic Membrane
	Molecular Function	Phosphoglycerate Kinase Activity Protein Binding ATP Binding	Protein Binding
	Biological Process	Carbohydrate Metabolic Process Glucose Metabolic Process Gluconeogenesis Glycolytic Process Pathogenesis Phosphorylation Epithelial Cell Differentiation Small Molecule Metabolic Process	Microtubule Cytoskeleton Organization Neuron Migration Positive Regulation Of Neuroblast Proliferation Regulation Of Neuron Projection Development Cerebral Cortex Radially Oriented Cell Migration Cell Proliferation In Forebrain Positive Regulation Of Wnt Signaling Pathway TOR Signaling Cellular Protein Localization Mitochondrial Calcium Ion Homeostasis Canonical Wnt Signaling Pathway Regulation Of Synapse Maturation Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Pathways		Gluconeogenesis Glucose metabolism Myoclonic epilepsy of Lafora Glycogen storage diseases Glycolysis Metabolism of carbohydrates
Drugs
Diseases
GWAS			Alzheimer's disease ( 19118814) Amyotrophic lateral sclerosis ( 19451621) Neuranatomic and neurocognitive phenotypes ( 21483430) Response to antineoplastic agents ( 21659360) Response to statin therapy ( 20339536)
Protein-Protein Interactions		7 interactors: DISC1 GAPDH HIF1A HSPH1 PCNA SUMO4 YWHAQ	113 interactors: ACTG1 ACTN2 AGTPBP1 AKAP6 AKAP9 ARIH2 ATF4 ATF5 ATF7IP BICD1 BZRAP1 C14orf166 CCDC136 CCDC141 CCDC24 CCDC88A CDC5L CDK5RAP3 CEP170 CEP57L1 CEP63 CIT CLU COL4A1 DCTN1 DCTN2 DMD DNAJC7 DPYSL2 DPYSL3 DST DYNC1H1 EEF2 EIF3H EXOC1 EXOC4 EXOC7 FBXO41 FEZ1 FRYL GNB1 GNPTAB GPRASP2 HERC2P2 IFT20 IMMT ITSN1 KALRN KANSL1 KCNQ5 KIAA1377 KIF3A KIF3C KIFAP3 MACF1 MAP1A MATR3 MEMO1 MLLT10 MPPED1 MVP MYO1A MYT1L NDE1 NDEL1 NEFM NUP160 OLFM1 PAFAH1B1 PCNT PCNXL4 PDE4B PGK1 PPM1E PPP4R1 PPP5C RABGAP1 RAD21 RANBP9 RASSF7 RBSN ROGDI SH3BP5 SMARCE1 SMC2 SMC3 SNX6 SPARCL1 SPTAN1 SPTBN1 SPTBN4 SRGAP2 SRGAP3 STX18 SYBU SYNE1 TFIP11 TIAM2 TNIK TNKS TRAF3IP1 TRIO TUBB TUBB2A UTRN XPNPEP1 XRN2 YWHAE YWHAG YWHAQ YWHAZ ZNF197 ZNF365
Entrez ID		5230	27185
HPRD ID		02412	05553
Ensembl ID		ENSG00000102144	ENSG00000162946
Uniprot IDs		B4E1H9 B7Z7A9 P00558	C4P094 C4P096 C4P098 C4P0A4 C4P0A5 C4P0C4 C4P0C8 C4P0D0 C4P0D1 C4P0D2 C4P0D3 Q9NRI5
PDB IDs		2WZB 2WZC 2WZD 2X13 2X14 2X15 2XE6 2XE7 2XE8 2Y3I 2YBE 2ZGV 3C39 3C3A 3C3B 3C3C 4AXX
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Neuroblast Proliferation Positive Regulation Of Neural Precursor Cell Proliferation Regulation Of Neuroblast Proliferation Positive Regulation Of Stem Cell Proliferation Neural Fold Elevation Formation Positive Regulation Of Deoxyribonuclease Activity Peptidyl-cysteine S-trans-nitrosylation Regulation Of Neural Precursor Cell Proliferation Regulation Of Stem Cell Proliferation Elastin Metabolic Process Leading Strand Elongation Cellular Homeostasis Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Chemokine-mediated Signaling Pathway Vascular Endothelial Growth Factor Production Cerebral Cortex Development Brain Development Microtubule-based Process Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development Intestinal Epithelial Cell Maturation Head Development Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Peptidyl-cysteine S-nitrosylation Positive Regulation Of NK T Cell Activation Positive Regulation Of MHC Class I Biosynthetic Process Pallium Development Hemoglobin Biosynthetic Process Axon Transport Of Mitochondrion Wound Healing Involved In Inflammatory Response Oxygen Homeostasis Negative Regulation Of Thymocyte Apoptotic Process Central Nervous System Development B-1 B Cell Homeostasis Negative Regulation Of Oxidative Stress-induced Neuron Death Regulation Of Transforming Growth Factor Beta2 Production Telencephalon Development Positive Regulation Of Receptor Biosynthetic Process Lactate Metabolic Process Translesion Synthesis Response To Organic Substance Positive Regulation Of Hormone Biosynthetic Process MRNA Transcription From RNA Polymerase II Promoter Positive Regulation Of Glycolytic Process Negative Regulation Of Mesenchymal Cell Apoptotic Process Response To Muscle Activity Hemoglobin Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress MRNA Transcription	Organelle Organization Movement Of Cell Or Subcellular Component Cellular Localization Microtubule-based Process Nervous System Development Establishment Of Localization In Cell Neurogenesis G2/M Transition Of Mitotic Cell Cycle Generation Of Neurons Microtubule Cytoskeleton Organization Cytoskeleton-dependent Intracellular Transport Mitotic Cell Cycle Process Cellular Component Assembly Cell Projection Organization Mitotic Cell Cycle Microtubule-based Transport Cell Cycle Process Organelle Localization Cytoskeleton Organization Cell Cycle Cell Projection Morphogenesis Cell Part Morphogenesis Anatomical Structure Development System Development Membrane Organization Cell Differentiation Cell Morphogenesis Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Organelle Transport Along Microtubule Developmental Process Protein Localization Microtubule-based Movement Axonogenesis Mitotic Nuclear Division Locomotion Establishment Of Organelle Localization Axon Guidance Vesicle Localization Axon Development Neuron Development Cellular Process Regulation Of Cellular Component Organization Multicellular Organismal Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Neurogenesis Cell Projection Assembly Neuron Differentiation Intracellular Transport Spindle Organization
Tagcloud ?		4a act1 apparatus carrying compete differing efficiencies enter entry exponential hsp12 hsp26 idea inert lacz leaders mrnas polysome pyk1 raising rp29 rpl3 saccharomyces starvation stationary thi4 translatabilities translated translational	accelerate aggregated allosteric amplify appropriated assemblies assembly biochemically capsid catalytically collections commonality conceptualized continuum crowded exploit governed labile machines multimers multiprotein pathologically prions replicating replicative reprogrammed reset suited transmissibility
Tagcloud (Difference) ?		4a act1 apparatus carrying compete differing efficiencies enter entry exponential hsp12 hsp26 idea inert lacz leaders mrnas polysome pyk1 raising rp29 rpl3 saccharomyces starvation stationary thi4 translatabilities translated translational	accelerate aggregated allosteric amplify appropriated assemblies assembly biochemically capsid catalytically collections commonality conceptualized continuum crowded exploit governed labile machines multimers multiprotein pathologically prions replicating replicative reprogrammed reset suited transmissibility
Tagcloud (Intersection) ?