PGK1 and GAPDH

Number of citations of the paper that reports this interaction (PubMedID 8075252)
0

Data Source:
HPRD (in vitro, in vivo)

		PGK1	GAPDH
Description		phosphoglycerate kinase 1	glyceraldehyde-3-phosphate dehydrogenase
Image
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Membrane Membrane Raft Extracellular Exosome	Nucleus Cytoplasm Lipid Droplet Cytosol Cytoskeleton Plasma Membrane Microtubule Cytoskeleton Membrane Nuclear Membrane Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome GAIT Complex Ribonucleoprotein Complex
	Molecular Function	Nucleotide Binding Phosphoglycerate Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity ADP Binding Transmembrane Transporter Binding Metal Ion Binding Protein-disulfide Reductase [NAD(P)H] Activity Protein Serine Kinase Activity	Glyceraldehyde-3-phosphate Dehydrogenase (NAD+) (phosphorylating) Activity Protein Binding Microtubule Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, NAD Or NADP As Acceptor Transferase Activity Aspartic-type Endopeptidase Inhibitor Activity Peptidyl-cysteine S-nitrosylase Activity Identical Protein Binding NADP Binding NAD Binding Disordered Domain Specific Binding
	Biological Process	Gluconeogenesis Glycolytic Process Negative Regulation Of Angiogenesis Epithelial Cell Differentiation Plasminogen Activation Canonical Glycolysis Cellular Response To Hypoxia Negative Regulation Of Pyruvate Decarboxylation To Acetyl-CoA	Microtubule Cytoskeleton Organization Positive Regulation Of Cytokine Production Immune System Process Glucose Metabolic Process Glycolytic Process Regulation Of Translation Apoptotic Process Negative Regulation Of Endopeptidase Activity Regulation Of Macroautophagy Negative Regulation Of Translation Killing Of Cells Of Another Organism Positive Regulation Of Type I Interferon Production Peptidyl-cysteine S-trans-nitrosylation Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Protein Stabilization Defense Response To Fungus Neuron Apoptotic Process Killing By Host Of Symbiont Cells Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cellular Response To Type II Interferon
Pathways		Glycolysis Gluconeogenesis Manipulation of host energy metabolism	Glycolysis Gluconeogenesis
Drugs		Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate 3-phospho-D-glyceric acid Copper Artenimol	NADH Adenosine-5-Diphosphoribose Thionicotinamide-Adenine-Dinucleotide 4-(2-Aminoethyl)Benzenesulfonyl Fluoride Xanthinol Copper Artenimol
Diseases		Anemia due to disorders of glycolytic enzymes, including: Hexokinase (HK) deficiency; Phosphoglycerate kinase 1 (PGK1) deficiency; Triose-phosphate isomerase (TPI) deficiency; Glucose phosphate isomerase (GPI) deficiency; Bisphosphoglycerate mutase (BPGM) deficiency
GWAS		Mean platelet volume ( 32888494)	Blood protein levels ( 30072576)
Interacting Genes		22 interacting genes: AR BECN1 CDC7 CEBPA CLIC6 CSNK2A1 DISC1 FNDC3B GAPDH HIF1A HSPH1 LINC01554 NAA10 OGT PCNA RHOU SUMO2 SUMO4 SUPT5H TUBA1A UBE3A YWHAQ	92 interacting genes: ACD ACTB ACTC1 ANXA1 ANXA7 APP AR ARL15 ATN1 ATXN1 BID BPGM BTBD2 CAMK1 CAMK2B CAMK4 CDKN1A CDKN2A CEBPA CHP1 DUX4 DYNLL1 EGFR ERBB2 FBXO7 FKBP6 FOXP1 GADD45A GAS7 GOT2 GRIA2 GRM1 HES1 HNF4G HSPB2 HTT ITGB5 KARS1 KAT5 KCNE3 LAMA4 LAMTOR5 LIG4 LINC01554 MAPK1 MTNR1A MYOC NFYC NR1H4 NUFIP2 OGT OSMR OSTF1 PAFAH1B3 PCDHA4 PCNA PDIA2 PGK1 PLD2 POT1 POU2F2 PPM1E PRDX1 PRKCI PRPF40A PSEN1 PSMD11 PTPRF RAB2A RBM5 RPA2 RXFP4 S100A6 SERPINB9 SHANK3 SIAH1 SIRT1 SLC2A1 SLC2A4 SMARCA2 SMN1 SUMO4 TERF1 TINF2 TK1 TPPP TSC2 TXNIP USP25 WEE2-AS1 YWHAE YWHAQ
Entrez ID		5230	2597
HPRD ID		02412	00713
Ensembl ID		ENSG00000102144	ENSG00000111640
Uniprot IDs		P00558 V9HWF4	P04406 V9HVZ4
PDB IDs		2WZB 2WZC 2WZD 2X13 2X14 2X15 2XE6 2XE7 2XE8 2Y3I 2YBE 2ZGV 3C39 3C3A 3C3B 3C3C 3ZOZ 4AXX 4O33 5M1R 5M3U 5M6Z 5MXM 5NP8 5O7D 8YHP	1U8F 1ZNQ 3GPD 4WNC 4WNI 6ADE 6IQ6 6M61 6YND 6YNE 6YNF 6YNH 8DNS 8G12 8G13 8G14 8G15 8G16 8G17 8P5F
Enriched GO Terms of Interacting Partners?		Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Catabolic Process Regulation Of Macroautophagy Positive Regulation Of Macroautophagy Positive Regulation Of Metabolic Process Rhythmic Process Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Protein-containing Complex Response To Metal Ion Negative Regulation Of Nucleobase-containing Compound Metabolic Process Prostate Gland Growth Positive Regulation Of Autophagy Regulation Of Autophagy Organelle Organization Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Nucleus Response To Steroid Hormone Cellular Response To Oxidative Stress Negative Regulation Of Macromolecule Biosynthetic Process Response To Ketone TOR Signaling Protein Tag Activity Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Protein Localization To Vacuole Negative Regulation Of Metabolic Process Response To L-glutamate Regulation Of Metabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Androgen Receptor Signaling Pathway Sin3-type Complex Cellular Response To Chemical Stress Neuron Apoptotic Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Epithelial Cell Maturation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Embryonic Placenta Development Regulation Of Macromolecule Metabolic Process Ubiquitin-like Protein Ligase Binding Positive Regulation Of Signal Transduction Positive Regulation Of Neuroblast Proliferation	Developmental Process Cellular Developmental Process Nucleus Cell Differentiation Regulation Of Programmed Cell Death Regulation Of Phosphorus Metabolic Process Shelterin Complex Regulation Of Cellular Component Organization Negative Regulation Of Metabolic Process Intracellular Signal Transduction Positive Regulation Of DNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Signal Transduction Regulation Of Apoptotic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Identical Protein Binding Nuclear Telomere Cap Complex Protein-containing Complex Regulation Of Cellular Localization Cellular Response To Stress Regulation Of Cellular Response To Stress Regulation Of Multicellular Organismal Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Protein Localization Regulation Of DNA Metabolic Process Telomeric DNA Binding Telomere Capping Regulation Of Phosphorylation Nucleoplasm Regulation Of Developmental Process Negative Regulation Of DNA Biosynthetic Process DNA Biosynthetic Process Telomere Assembly Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Cell Cycle Regulation Of Chromosome Organization Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Phosphate Metabolic Process Regulation Of Cell Population Proliferation Negative Regulation Of Biosynthetic Process Cytosol Positive Regulation Of Programmed Cell Death Positive Regulation Of Signaling Positive Regulation Of Chromosome Organization Positive Regulation Of Multicellular Organismal Process Regulation Of Cell Development Positive Regulation Of Cellular Component Organization System Development
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