- and CRYAA

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		-	CRYAA
Description		crystallin alpha A2	crystallin alpha A
Image
GO Annotations	Cellular Component		Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex
	Molecular Function		Structural Molecule Activity Structural Constituent Of Eye Lens Protein Binding Identical Protein Binding Metal Ion Binding Unfolded Protein Binding
	Biological Process		Response To Hypoxia Lens Development In Camera-type Eye Lens Morphogenesis In Camera-type Eye Apoptotic Process Mitochondrion Organization Actin Filament Organization Microtubule-based Process Tubulin Complex Assembly Visual Perception Response To Heat Negative Regulation Of Gene Expression Positive Regulation Of Cell Growth Negative Regulation Of Intracellular Transport Protein Refolding Response To Hydrogen Peroxide Camera-type Eye Development Negative Regulation Of Apoptotic Process Embryonic Camera-type Eye Morphogenesis Protein Stabilization Apoptotic Process Involved In Morphogenesis Response To UV-A Lens Fiber Cell Morphogenesis
Pathways
Drugs
Diseases
GWAS		HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535)	Age-related nuclear cataracts ( 24951543 33311586) Diastolic blood pressure ( 27618452 27841878 28135244 28739976) Metabolite levels ( 23823483) Systolic blood pressure ( 27618452 27841878 28739976)
Interacting Genes		6 interacting genes: CRYAA CRYAB GORASP2 NTAQ1 SDCBP SPG21	134 interacting genes: - ADPRHL1 AKT3 ALB ALDH1L2 ANKRD44 APPL2 ARFGAP1 ARMCX4 ARRDC1-AS1 ATG16L1 BCL2L1 BORA BTRC CAMKK2 CD209 CDC40 CEBPZ CENPH CER1 CNOT8 COPB2 CRTAC1 CRYAB CRYBA1 CRYBB2 CRYGC CRYGD CRYZ CS CSTF2T DCAF11 DCAF8 DCK DDX3X DUS4L E2F7 EEPD1 ETFB EYA4 FAM131B FAM131C FAM182A FASN GIGYF2 GLYATL1 GNAI2 GORASP2 GSTZ1 HABP4 HCLS1 HSPB1 HSPB2 IGHG1 IGKV1-5 JKAMP KBTBD12 KIZ KNG1 LALBA LARP6 LIMA1 MAP3K7CL MAPKBP1 MCM7 MCRS1 MINDY1 MIP MPHOSPH6 MTERF4 MYO5C NAT9 NCF4 NTAQ1 NUP43 OSBPL3 OTOGL OTULIN PABIR2 PAFAH1B1 PCYT2 PHC1 PLAUR PMS2 PRM2 PSMB6 PTPN2 PTTG2 QRICH1 RAB24 RAB29 RAB3C RAB40B RAB43 RAD51 RBBP7 RNASEH1 RNGTT RPS6KA5 SDCBP SEC24C SEH1L SESN2 SGCD SLC20A1 SLC25A25 SLC25A26 SLC25A28 SPG21 SSBP4 SULF1 SYK TASL TEAD4 TFDP1 TGOLN2 TLE4 TMEM254 TMEM52B TSR3 TTC27 TTC39B TUBAL3 TUBGCP5 UBR2 UPP1 WDR55 WDR83 WIPI2 WWC2 ZIM2 ZNF3 ZNF639 ZSCAN20
Entrez ID		102724652	1409
HPRD ID			00427
Ensembl ID		ENSG00000276076	ENSG00000160202
Uniprot IDs		A0A8C8KJZ9 P02489	A0A8C8KJZ9 P02489
PDB IDs		6T1R	6T1R
Enriched GO Terms of Interacting Partners?		Tubulin Complex Assembly Structural Constituent Of Eye Lens Apoptotic Process Involved In Morphogenesis Protein Refolding Apoptotic Process Involved In Development Lens Development In Camera-type Eye Negative Regulation Of Intracellular Transport Regulation Of Cell Growth Negative Regulation Of Transport Response To Heat Camera-type Eye Development Interleukin-5 Receptor Complex Protein-N-terminal Glutamine Amidohydrolase Activity Response To Hydrogen Peroxide Unfolded Protein Binding Interleukin-5 Receptor Binding Protein-N-terminal Asparagine Amidohydrolase Activity Eye Development Regulation Of Growth Response To Temperature Stimulus Positive Regulation Of Cell Growth Response To Reactive Oxygen Species Positive Regulation Of Extracellular Exosome Assembly Syndecan Binding Sensory Organ Development Structural Molecule Activity Protein Folding Establishment Of Protein Localization To Membrane Regulation Of Extracellular Exosome Assembly Lens Fiber Cell Morphogenesis Cardiac Myofibril Protein Stabilization Positive Regulation Of Growth Actin Filament Bundle CD4 Receptor Binding Regulation Of Intracellular Transport Substrate-dependent Cell Migration, Cell Extension Response To UV-A Response To Hypoxia Response To Decreased Oxygen Levels Cellular Component Assembly Lens Morphogenesis In Camera-type Eye Negative Regulation Of Amyloid Fibril Formation Contractile Muscle Fiber Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Embryonic Camera-type Eye Morphogenesis Positive Regulation Of Exosomal Secretion Organelle Organization Response To Oxygen Levels Negative Regulation Of Receptor Internalization	Structural Constituent Of Eye Lens Lens Development In Camera-type Eye
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