NBR1 and FEZ1

Number of citations of the paper that reports this interaction (PMID 11856312)
11

Data Source:
HPRD (in vivo, two hybrid)

		NBR1	FEZ1
Gene Name		neighbor of BRCA1 gene 1	fasciculation and elongation protein zeta 1 (zygin I)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Pre-autophagosomal Structure Lysosome Late Endosome Autophagic Vacuole Cytosol Membrane Cytoplasmic Vesicle M Band Extracellular Vesicular Exosome	Cytoplasm Mitochondrion Centrosome Microtubule Plasma Membrane Microtubule Cytoskeleton Axon Dendrite
	Molecular Function	Protein Binding Zinc Ion Binding Ubiquitin Binding Mitogen-activated Protein Kinase Binding	Protein Kinase C Binding Protein Binding Gamma-tubulin Binding Protein N-terminus Binding
	Biological Process	Macroautophagy Regulation Of Bone Mineralization Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Osteoblast Differentiation Protein Oligomerization	Transport Cell Adhesion Nervous System Development Axon Guidance Positive Regulation Of Neuron Projection Development Establishment Of Mitochondrion Localization Cellular Response To Growth Factor Stimulus
Pathways
Drugs
Diseases
GWAS			Schizophrenia ( 22688191 23894747)
Protein-Protein Interactions		14 interactors: ATXN1L CALM1 CIB1 FEZ1 GABARAPL2 GSK3A GSK3B ITSN2 MAP1LC3A SQSTM1 SYT4 TTN USP8 VTA1	57 interactors: BARD1 BORA BRD1 C16orf59 C8orf33 CCL7 CIB1 CLASP2 COL9A2 CSTF2 DIS3L2 DISC1 DNAAF5 DRAP1 FEZ2 GEMIN7 GTF2F1 HAP1 HTATSF1 HTT IMMT KIAA1377 LRIF1 MEST NBR1 NDUFB9 NEK1 OLFML3 P4HB PAM16 PDCD7 PRKCZ PTH PTN PTPRS RAB3GAP1 RAB3GAP2 RAI14 RIF1 SAP30L SCOC SERPINH1 SMARCD1 SMC3 SMEK2 STAR TAC3 TAF1D TAF9 TBC1D25 TLK2 TOMM20 TTR TXNDC9 UBE4B WWC1 ZNF251
Entrez ID		4077	9638
HPRD ID		01326	09212
Ensembl ID		ENSG00000188554	ENSG00000149557
Uniprot IDs		Q14596	Q99689
PDB IDs		1WJ6 2BKF 2CP8 2G4S 2L8J
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Type B Pancreatic Cell Development Cellular Response To Growth Factor Stimulus Response To Growth Factor Hypermethylation Of CpG Island Cellular Response To Interleukin-3 Regulation Of Cellular Protein Metabolic Process Macroautophagy Establishment Of Localization In Cell Glycogen Metabolic Process Negative Regulation Of Glycogen (starch) Synthase Activity Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Protein Metabolic Process Polysaccharide Metabolic Process Negative Regulation Of Cardiac Muscle Hypertrophy Regulation Of Protein Phosphorylation Negative Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Muscle Hypertrophy Regulation Of Glycogen (starch) Synthase Activity Cellular Localization Extrinsic Apoptotic Signaling Pathway Response To Metal Ion Response To External Stimulus Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Protein Phosphorylation Apoptotic Signaling Pathway Cellular Response To Nitrogen Starvation Regulation Of Protein Kinase Activity Regulation Of Phosphorylation Regulation Of Protein Catabolic Process Regulation Of Kinase Activity Negative Regulation Of Transport Energy Reserve Metabolic Process Regulation Of DNA Methylation Cellular Response To Starvation Nucleophagy Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Phosphorylation Regulation Of Intracellular Transport Regulation Of Phosphorus Metabolic Process Autophagy Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Gene Expression By Genetic Imprinting Mitochondrion Degradation Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cellular Response To Stress See more	Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Organelle Organization Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Regulation Of Cellular Process Vesicle Transport Along Microtubule Cell Cycle Mitotic Cell Cycle Microtubule-based Process Microtubule Cytoskeleton Organization Regulation Of Metabolic Process Response To Radiation Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Heterocycle Metabolic Process Cellular Process Cellular Homeostasis Organelle Transport Along Microtubule Positive Regulation Of Metabolic Process Response To Ionizing Radiation Response To Stimulus Movement Of Cell Or Subcellular Component Cell Division Regulation Of Intracellular Signal Transduction Cell Cycle Process Regulation Of Synaptic Plasticity Nucleobase-containing Compound Metabolic Process Cellular Response To DNA Damage Stimulus Regulation Of Synaptic Transmission Regulation Of Microtubule-based Process Response To Abiotic Stimulus Cellular Nitrogen Compound Metabolic Process Establishment Or Maintenance Of Cell Polarity Cellular Metabolic Process Mitotic Nuclear Division Mitotic Cell Cycle Process Homeostatic Process Regulation Of Signal Transduction Regulation Of Signaling Mitochondrial Calcium Ion Homeostasis Regulation Of Organelle Organization Cellular Aromatic Compound Metabolic Process Regulation Of Cellular Component Organization Nitrogen Compound Metabolic Process DNA-templated Transcription, Elongation Establishment Of Protein Localization To Organelle Anatomical Structure Development Nervous System Development RNA Metabolic Process Diencephalon Development Transcription, DNA-templated See more
Tagcloud ?		abrogates autophagy bnip3l carried connections endoplasmic er extent hct116 interest ire1 microarray nix p62 particular perk regulates reticulum sqstm1 stages still stress subjected transcriptional transmembrane unclear unfolded upr upregulation	atf5 burden credible disc1 disordered endophenotypes highlighting intriguing intrinsically lis maf missense nde1 ndel1 neuropsychiatric partners pde4b psychiatric reside schizophrenia striking swedish synonymous sz traf3ip1 unexplored variants ywhae znf365
Tagcloud (Difference) ?		abrogates autophagy bnip3l carried connections endoplasmic er extent hct116 interest ire1 microarray nix p62 particular perk regulates reticulum sqstm1 stages still stress subjected transcriptional transmembrane unclear unfolded upr upregulation	atf5 burden credible disc1 disordered endophenotypes highlighting intriguing intrinsically lis maf missense nde1 ndel1 neuropsychiatric partners pde4b psychiatric reside schizophrenia striking swedish synonymous sz traf3ip1 unexplored variants ywhae znf365
Tagcloud (Intersection) ?