NBR1

Gene Name		neighbor of BRCA1 gene 1
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Gene Ontology Annotations	Cellular Component	Pre-autophagosomal Structure Lysosome Late Endosome Autophagic Vacuole Cytosol Membrane Cytoplasmic Vesicle M Band Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Zinc Ion Binding Ubiquitin Binding Mitogen-activated Protein Kinase Binding
	Biological Process	Macroautophagy Regulation Of Bone Mineralization Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Osteoblast Differentiation Protein Oligomerization
Pathways
Drugs
Diseases
GWAS
Protein-protein Interactions		14 interactors: ATXN1L CALM1 CIB1 FEZ1 GABARAPL2 GSK3A GSK3B ITSN2 MAP1LC3A SQSTM1 SYT4 TTN USP8 VTA1
Entrez ID		4077
HPRD ID		01326
Ensembl ID		ENSG00000188554
Uniprot IDs		Q14596
PDB IDs		1WJ6 2BKF 2CP8 2G4S 2L8J
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Type B Pancreatic Cell Development Cellular Response To Growth Factor Stimulus Response To Growth Factor Hypermethylation Of CpG Island Cellular Response To Interleukin-3 Regulation Of Cellular Protein Metabolic Process Macroautophagy Establishment Of Localization In Cell Glycogen Metabolic Process Negative Regulation Of Glycogen (starch) Synthase Activity Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Protein Metabolic Process Polysaccharide Metabolic Process Negative Regulation Of Cardiac Muscle Hypertrophy Regulation Of Protein Phosphorylation Negative Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Muscle Hypertrophy Regulation Of Glycogen (starch) Synthase Activity Cellular Localization Extrinsic Apoptotic Signaling Pathway Response To Metal Ion Response To External Stimulus Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Protein Phosphorylation Apoptotic Signaling Pathway Cellular Response To Nitrogen Starvation Regulation Of Protein Kinase Activity Regulation Of Phosphorylation Regulation Of Protein Catabolic Process Regulation Of Kinase Activity Negative Regulation Of Transport Energy Reserve Metabolic Process Regulation Of DNA Methylation Cellular Response To Starvation Nucleophagy Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Phosphorylation Regulation Of Intracellular Transport Regulation Of Phosphorus Metabolic Process Autophagy Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Gene Expression By Genetic Imprinting Mitochondrion Degradation Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cellular Response To Stress
Tagcloud ?		abrogates autophagy bnip3l carried connections endoplasmic er extent hct116 interest ire1 microarray nix p62 particular perk regulates reticulum sqstm1 stages still stress subjected transcriptional transmembrane unclear unfolded upr upregulation