NBR1

Name	NBR1 autophagy cargo receptor
Structure
Interactors	22 interactors: ACAD10 ATXN1L AXIN1 CALM1 CIB1 FEZ1 GABARAP GABARAPL2 GSK3A GSK3B ITSN2 MAP1LC3A MAP2K4 METAP1 SQSTM1 SYT4 TTN UBC UBE2D2 UBE2D3 USP8 VTA1
GO Annotations	Cellular Component	Phagophore Assembly Site Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Lysosome Late Endosome Autophagosome Peroxisomal Membrane Cytosol Membrane Nuclear Body Cytoplasmic Vesicle M Band Receptor Complex Intracellular Organelle Lumen
	Molecular Function	Protein Binding Zinc Ion Binding Ubiquitin Binding Metal Ion Binding Mitogen-activated Protein Kinase Binding
	Biological Process	Macroautophagy Regulation Of Bone Mineralization Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Osteoblast Differentiation
Pathways	Pexophagy Pexophagy
GWAS	No GWAS studies recorded
Entrez ID	4077
HPRD ID	01326
Ensembl ID	ENSG00000188554
Uniprot IDs	B7Z5R6 Q14596
PDB IDs	1WJ6 2BKF 2CP8 2G4S 2L8J 2MGW 2MJ5 4OLE
GO Terms Enriched among Interactors ?	Ubiquitin Protein Ligase Binding Cellular Response To Nitrogen Starvation Beta-catenin Destruction Complex Regulation Of Protein Localization Catabolic Process Mitophagy Phosphatidylethanolamine Binding Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Macroautophagy Organelle Organization Autophagy Of Mitochondrion Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Autophagosome Regulation Of Protein Ubiquitination Regulation Of Proteasomal Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Proteolysis Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Glycogen (starch) Synthase Activity Cytosol Regulation Of Post-translational Protein Modification Positive Regulation Of Proteasomal Protein Catabolic Process Extrinsic Apoptotic Signaling Pathway Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Proteolysis Involved In Protein Catabolic Process Organelle Assembly Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Sperm Midpiece Cellular Response To Interleukin-3 Autophagy Protein-containing Complex Disassembly Autophagosome Maturation Regulation Of Establishment Of Protein Localization Positive Regulation Of Establishment Of Protein Localization Regulation Of Type B Pancreatic Cell Development Autophagosome Membrane Apoptotic Signaling Pathway Negative Regulation Of Glycogen Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Vesicle Negative Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process