NBR1 and MAP1LC3A

Number of citations of the paper that reports this interaction (PMID 19250911)
178

Data Source:
BioGRID (affinity chromatography technology, two hybrid, pull down, affinity chromatography technology)

		NBR1	MAP1LC3A
Gene Name		neighbor of BRCA1 gene 1	microtubule-associated protein 1 light chain 3 alpha
Image
Gene Ontology Annotations	Cellular Component	Pre-autophagosomal Structure Lysosome Late Endosome Autophagic Vacuole Cytosol Membrane Cytoplasmic Vesicle M Band Extracellular Vesicular Exosome	Pre-autophagosomal Structure Autophagic Vacuole Membrane Late Endosome Autophagic Vacuole Cytosol Microtubule Extrinsic Component Of Membrane Organelle Membrane Cytoplasmic Vesicle
	Molecular Function	Protein Binding Zinc Ion Binding Ubiquitin Binding Mitogen-activated Protein Kinase Binding	Protein Binding Phospholipid Binding Microtubule Binding Phosphatidylethanolamine Binding GABA Receptor Binding
	Biological Process	Macroautophagy Regulation Of Bone Mineralization Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Osteoblast Differentiation Protein Oligomerization	Autophagic Vacuole Assembly Mitochondrion Degradation Cellular Response To Nitrogen Starvation Nucleophagy Membrane Fusion
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: ATXN1L CALM1 CIB1 FEZ1 GABARAPL2 GSK3A GSK3B ITSN2 MAP1LC3A SQSTM1 SYT4 TTN USP8 VTA1	40 interactors: AKAP13 APP ATG101 ATG13 ATG3 ATG4B ATG7 BNIP3L DVL2 EPHA7 FAM134C FUNDC1 KIF15 KXD1 MAP1A MAP1S NBR1 OPTN PIAS4 PRPF40A RABGAP1 RABGAP1L RDH12 RTKN SQSTM1 SRPK1 TBC1D1 TBC1D10A TBC1D10B TBC1D16 TBC1D17 TBC1D2 TBC1D25 TBC1D2B TBC1D5 TBC1D7 TBC1D9 TBC1D9B TNIP1 TUBA4A
Entrez ID		4077	84557
HPRD ID		01326	03144
Ensembl ID		ENSG00000188554	ENSG00000101460
Uniprot IDs		Q14596	Q9H492
PDB IDs		1WJ6 2BKF 2CP8 2G4S 2L8J	3ECI
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Type B Pancreatic Cell Development Cellular Response To Growth Factor Stimulus Response To Growth Factor Hypermethylation Of CpG Island Cellular Response To Interleukin-3 Regulation Of Cellular Protein Metabolic Process Macroautophagy Establishment Of Localization In Cell Glycogen Metabolic Process Negative Regulation Of Glycogen (starch) Synthase Activity Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Protein Metabolic Process Polysaccharide Metabolic Process Negative Regulation Of Cardiac Muscle Hypertrophy Regulation Of Protein Phosphorylation Negative Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Muscle Hypertrophy Regulation Of Glycogen (starch) Synthase Activity Cellular Localization Extrinsic Apoptotic Signaling Pathway Response To Metal Ion Response To External Stimulus Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Protein Phosphorylation Apoptotic Signaling Pathway Cellular Response To Nitrogen Starvation Regulation Of Protein Kinase Activity Regulation Of Phosphorylation Regulation Of Protein Catabolic Process Regulation Of Kinase Activity Negative Regulation Of Transport Energy Reserve Metabolic Process Regulation Of DNA Methylation Cellular Response To Starvation Nucleophagy Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Phosphorylation Regulation Of Intracellular Transport Regulation Of Phosphorus Metabolic Process Autophagy Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Gene Expression By Genetic Imprinting Mitochondrion Degradation Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cellular Response To Stress	Positive Regulation Of Rab GTPase Activity Regulation Of Rab GTPase Activity Regulation Of Rab Protein Signal Transduction Autophagy Positive Regulation Of Ras GTPase Activity Regulation Of Ras Protein Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Ras GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of GTPase Activity Regulation Of GTPase Activity Positive Regulation Of Hydrolase Activity Regulation Of Signal Transduction Macroautophagy Response To Starvation Regulation Of Signaling Positive Regulation Of Catalytic Activity Cellular Response To Starvation Cellular Response To Nutrient Levels Regulation Of Catalytic Activity Positive Regulation Of Metabolic Process Cellular Response To Extracellular Stimulus Response To Nutrient Levels Response To Extracellular Stimulus Mitochondrion Degradation Catabolic Process Positive Regulation Of Autophagy Organelle Disassembly Autophagic Vacuole Assembly Regulation Of Metabolic Process Response To External Stimulus Intracellular Transport Retrograde Transport, Endosome To Golgi Nucleophagy Establishment Of Localization In Cell Cellular Localization Endosomal Transport Vacuole Organization Regulation Of Autophagy Cell Death Death Response To Stress Regulation Of Cellular Process Apoptotic Process Programmed Cell Death Organelle Organization Positive Regulation Of Macroautophagy Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cellular Response To Nitrogen Starvation
Tagcloud ?		abrogates autophagy bnip3l carried connections endoplasmic er extent hct116 interest ire1 microarray nix p62 particular perk regulates reticulum sqstm1 stages still stress subjected transcriptional transmembrane unclear unfolded upr upregulation	acquiring adenocarcinoma autophagy became came constitutive date demethylation egfr erlotinib escaping exposing gefitinib ie immunoreactivity necessarily neoplastic novo overcoming parental pc9 pivotal predictor pronounced restores tkis treating tumoural
Tagcloud (Difference) ?		abrogates bnip3l carried connections endoplasmic er extent hct116 interest ire1 microarray nix p62 particular perk regulates reticulum sqstm1 stages still stress subjected transcriptional transmembrane unclear unfolded upr upregulation	acquiring adenocarcinoma became came constitutive date demethylation egfr erlotinib escaping exposing gefitinib ie immunoreactivity necessarily neoplastic novo overcoming parental pc9 pivotal predictor pronounced restores tkis treating tumoural
Tagcloud (Intersection) ?		autophagy