NBR1 and METAP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NBR1	METAP1
Description		NBR1 autophagy cargo receptor	methionyl aminopeptidase 1
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GO Annotations	Cellular Component	Phagophore Assembly Site Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Lysosome Late Endosome Autophagosome Peroxisomal Membrane Cytosol Membrane Nuclear Body Cytoplasmic Vesicle M Band Receptor Complex Intracellular Organelle Lumen	Cytoplasm Cytosol Cytosolic Ribosome
	Molecular Function	Protein Binding Zinc Ion Binding Ubiquitin Binding Metal Ion Binding Mitogen-activated Protein Kinase Binding	Aminopeptidase Activity Initiator Methionyl Aminopeptidase Activity Protein Binding Peptidase Activity Metalloexopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding Metalloaminopeptidase Activity
	Biological Process	Macroautophagy Regulation Of Bone Mineralization Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Osteoblast Differentiation	Regulation Of Translation Proteolysis Protein Maturation Platelet Aggregation
Pathways		Pexophagy Pexophagy	Inactivation, recovery and regulation of the phototransduction cascade
Drugs			Ovalicin 5-CHLORO-6-METHYL-N-(2-PHENYLETHYL)-2-PYRIDIN-2-YLPYRIMIDIN-4-AMINE TERT-BUTYL {2-[(1,3-THIAZOL-2-YLAMINO)CARBONYL]PYRIDIN-3-YL}CARBAMATE 3-[(2,2-DIMETHYLPROPANOYL)AMINO]-N-1,3-THIAZOL-2-YLPYRIDINE-2-CARBOXAMIDE
Diseases
GWAS			Alcohol consumption (drinks per week) ( 30643258) Alcohol dependence ( 33290381) Alcohol use disorder (consumption score) ( 30336701) Alcohol use disorder (dependence and problematic use scores) ( 30336701) Alcohol use disorder (total score) ( 30336701) Oral cavity and pharyngeal cancer ( 27749845) Regular attendance at a pub or social club ( 29970889)
Interacting Genes		22 interacting genes: ACAD10 ATXN1L AXIN1 CALM1 CIB1 FEZ1 GABARAP GABARAPL2 GSK3A GSK3B ITSN2 MAP1LC3A MAP2K4 METAP1 SQSTM1 SYT4 TTN UBC UBE2D2 UBE2D3 USP8 VTA1	8 interacting genes: DSCAM GLRX3 INCA1 MEOX2 NBR1 PLEKHG4 RBM11 SMAD9
Entrez ID		4077	23173
HPRD ID		01326	10071
Ensembl ID		ENSG00000188554	ENSG00000164024
Uniprot IDs		B7Z5R6 Q14596	P53582
PDB IDs		1WJ6 2BKF 2CP8 2G4S 2L8J 2MGW 2MJ5 4OLE	2B3H 2B3K 2B3L 2G6P 2GZ5 2NQ6 2NQ7 4FLI 4FLJ 4FLK 4FLL 4HXX 4IKR 4IKS 4IKT 4IKU 4IU6 4U1B 4U69 4U6C 4U6E 4U6J 4U6W 4U6Z 4U70 4U71 4U73 4U75 4U76 5YKP 5YR4 5YR5 5YR6 5YR7 6LZB 6LZC 8P2K 9F1C 9F1D 9FQ0
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Binding Cellular Response To Nitrogen Starvation Beta-catenin Destruction Complex Regulation Of Protein Localization Catabolic Process Mitophagy Phosphatidylethanolamine Binding Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Macroautophagy Organelle Organization Autophagy Of Mitochondrion Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Autophagosome Regulation Of Protein Ubiquitination Regulation Of Proteasomal Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Proteolysis Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Glycogen (starch) Synthase Activity Cytosol Regulation Of Post-translational Protein Modification Positive Regulation Of Proteasomal Protein Catabolic Process Extrinsic Apoptotic Signaling Pathway Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Proteolysis Involved In Protein Catabolic Process Organelle Assembly Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Sperm Midpiece Cellular Response To Interleukin-3 Autophagy Protein-containing Complex Disassembly Autophagosome Maturation Regulation Of Establishment Of Protein Localization Positive Regulation Of Establishment Of Protein Localization Regulation Of Type B Pancreatic Cell Development Autophagosome Membrane Apoptotic Signaling Pathway Negative Regulation Of Glycogen Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Vesicle Negative Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process
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