NBR1 and USP8

Number of citations of the paper that reports this interaction (PMID 19427866)
16

Data Source:
BioGRID (pull down)

		NBR1	USP8
Gene Name		neighbor of BRCA1 gene 1	ubiquitin specific peptidase 8
Image
Gene Ontology Annotations	Cellular Component	Pre-autophagosomal Structure Lysosome Late Endosome Autophagic Vacuole Cytosol Membrane Cytoplasmic Vesicle M Band Extracellular Vesicular Exosome	Acrosomal Vesicle Nucleoplasm Cytoplasm Early Endosome Golgi Apparatus Cytosol Extrinsic Component Of Plasma Membrane Midbody Extrinsic Component Of Endosome Membrane
	Molecular Function	Protein Binding Zinc Ion Binding Ubiquitin Binding Mitogen-activated Protein Kinase Binding	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding SH3 Domain Binding
	Biological Process	Macroautophagy Regulation Of Bone Mineralization Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Osteoblast Differentiation Protein Oligomerization	Mitotic Cytokinesis Endosome Organization Ras Protein Signal Transduction Cell Proliferation Protein Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination
Pathways			Signaling by ERBB2 Downregulation of ERBB2:ERBB3 signaling misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation regulation of FZD by ubiquitination XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: ATXN1L CALM1 CIB1 FEZ1 GABARAPL2 GSK3A GSK3B ITSN2 MAP1LC3A SQSTM1 SYT4 TTN USP8 VTA1	30 interactors: BIRC6 CHMP1A CHMP1B CHMP2A CHMP2B CHMP4C CHMP7 DNAJB6 GRAP2 GRB2 KIF23 NBR1 PJA1 PLA2G2A RASGRF1 RNF41 SLBP SPP1 SRC STAM STAM2 TRIM54 TRIM55 TRIM63 UBC USP15 USP21 USP28 YWHAG YWHAQ
Entrez ID		4077	9101
HPRD ID		01326	04405
Ensembl ID		ENSG00000188554	ENSG00000138592
Uniprot IDs		Q14596	P40818
PDB IDs		1WJ6 2BKF 2CP8 2G4S 2L8J	1WHB 2A9U 2GFO 2GWF 3N3K
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Type B Pancreatic Cell Development Cellular Response To Growth Factor Stimulus Response To Growth Factor Hypermethylation Of CpG Island Cellular Response To Interleukin-3 Regulation Of Cellular Protein Metabolic Process Macroautophagy Establishment Of Localization In Cell Glycogen Metabolic Process Negative Regulation Of Glycogen (starch) Synthase Activity Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Protein Metabolic Process Polysaccharide Metabolic Process Negative Regulation Of Cardiac Muscle Hypertrophy Regulation Of Protein Phosphorylation Negative Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Muscle Hypertrophy Regulation Of Glycogen (starch) Synthase Activity Cellular Localization Extrinsic Apoptotic Signaling Pathway Response To Metal Ion Response To External Stimulus Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Protein Phosphorylation Apoptotic Signaling Pathway Cellular Response To Nitrogen Starvation Regulation Of Protein Kinase Activity Regulation Of Phosphorylation Regulation Of Protein Catabolic Process Regulation Of Kinase Activity Negative Regulation Of Transport Energy Reserve Metabolic Process Regulation Of DNA Methylation Cellular Response To Starvation Nucleophagy Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Phosphorylation Regulation Of Intracellular Transport Regulation Of Phosphorus Metabolic Process Autophagy Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Gene Expression By Genetic Imprinting Mitochondrion Degradation Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cellular Response To Stress	Cell Separation After Cytokinesis Regulation Of Mitotic Spindle Assembly Regulation Of Spindle Assembly Mitotic Metaphase Plate Congression Metaphase Plate Congression Regulation Of Mitotic Spindle Organization Establishment Of Chromosome Localization Vacuolar Transport Mitotic Sister Chromatid Segregation Sister Chromatid Segregation Cell Cycle Process Regulation Of Centrosome Duplication Cell Cycle Mitotic Nuclear Division Regulation Of Centrosome Cycle Mitotic Cell Cycle Process Endosomal Transport Regulation Of Organelle Organization Nucleus Organization Mitotic Cell Cycle Regulation Of Cell Division Regulation Of Microtubule Cytoskeleton Organization Cell Division Membrane Organization Regulation Of Microtubule-based Process Regulation Of Cell Cycle Process Intracellular Transport Regulation Of Protein Complex Assembly Regulation Of Cellular Component Organization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Chromosome Segregation Negative Regulation Of ERBB Signaling Pathway Regulation Of Mitotic Nuclear Division Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Cell Cycle Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Establishment Of Localization In Cell Regulation Of Cytoskeleton Organization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Establishment Of Organelle Localization Regulation Of ERBB Signaling Pathway Virion Assembly Viral Life Cycle Proteolysis Involved In Cellular Protein Catabolic Process Viral Process Regulation Of Cellular Process Cellular Protein Catabolic Process Protein Transport
Tagcloud ?		abrogates autophagy bnip3l carried connections endoplasmic er extent hct116 interest ire1 microarray nix p62 particular perk regulates reticulum sqstm1 stages still stress subjected transcriptional transmembrane unclear unfolded upr upregulation	ampa ampar ampars antagonizes dephosphorylation deubiquitinating deubiquitination downscaling dub e3 forces homeostatic internalization inversely ligase lysosomes mechanistic nedd4 nmdar opposing plasticity redistributed scaling spines strength strikingly synapses synaptic ubiquitination
Tagcloud (Difference) ?		abrogates autophagy bnip3l carried connections endoplasmic er extent hct116 interest ire1 microarray nix p62 particular perk regulates reticulum sqstm1 stages still stress subjected transcriptional transmembrane unclear unfolded upr upregulation	ampa ampar ampars antagonizes dephosphorylation deubiquitinating deubiquitination downscaling dub e3 forces homeostatic internalization inversely ligase lysosomes mechanistic nedd4 nmdar opposing plasticity redistributed scaling spines strength strikingly synapses synaptic ubiquitination
Tagcloud (Intersection) ?