NBR1 and SYT4

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		NBR1	SYT4
Name		NBR1 autophagy cargo receptor	synaptotagmin 4
Structure
GO Annotations	Cellular Component	Phagophore Assembly Site Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Lysosome Late Endosome Autophagosome Peroxisomal Membrane Cytosol Membrane Nuclear Body Cytoplasmic Vesicle M Band Receptor Complex Intracellular Organelle Lumen	Golgi Membrane Golgi Apparatus Plasma Membrane Membrane Axon Dendrite Synaptic Vesicle Membrane Dense Core Granule Cytoplasmic Vesicle Vesicle Dense Core Granule Membrane Somatodendritic Compartment Neuron Projection Neuronal Cell Body Synapse Perinuclear Region Of Cytoplasm Exocytic Vesicle Astrocyte Projection Glutamatergic Synapse Neuronal Dense Core Vesicle Neuronal Dense Core Vesicle Membrane Microvesicle
	Molecular Function	Protein Binding Zinc Ion Binding Ubiquitin Binding Metal Ion Binding Mitogen-activated Protein Kinase Binding	SNARE Binding Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Metal Ion Binding Calcium Ion Sensor Activity
	Biological Process	Macroautophagy Regulation Of Bone Mineralization Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Osteoblast Differentiation	Vesicle Fusion Neurotransmitter Secretion Memory Positive Regulation Of Glutamate Secretion Regulation Of Dopamine Secretion Vesicle-mediated Transport Regulation Of Calcium Ion-dependent Exocytosis Regulation Of Endocytosis Cell Differentiation Regulation Of Vesicle Fusion Negative Regulation Of Catecholamine Secretion Negative Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Calcium Ion-dependent Exocytosis Negative Regulation Of Short-term Neuronal Synaptic Plasticity Negative Regulation Of Protein Secretion Calcium-dependent Activation Of Synaptic Vesicle Fusion Dense Core Granule Cytoskeletal Transport Regulation Of Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Regulation Of Postsynaptic Dense Core Vesicle Exocytosis Negative Regulation Of Secretion By Cell Positive Regulation Of Dendrite Extension Positive Regulation Of Dense Core Granule Exocytosis Negative Regulation Of Retrograde Trans-synaptic Signaling By Neuropeptide Negative Regulation Of Synaptic Vesicle Exocytosis
Pathways		Pexophagy Pexophagy	None
GWAS		No GWAS studies recorded	Accelerometer-based physical activity measurement (average acceleration) ( 29899525 ) Body mass index ( 25673413 28892062 ) Carotid intima media thickness x smoking interaction ( 32117412 ) Ceramide levels (C24:0) ( 32489964 ) Coffee consumption ( 31046077 ) Metabolite levels ( 23823483 ) Parkinson's disease ( 28892059 21738487 ) Physical activity (moderate intensity activity duration) ( 30531941 ) Physical activity (overall physical activity time) ( 30531941 ) Plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease ( 29748315 ) Pulse pressure ( 27841878 ) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271 ) Squamous cell lung carcinoma ( 28604730 ) Systolic blood pressure ( 27841878 ) Systolic blood pressure and diastolic blood pressure (bivariate analysis) ( 33539483 )
Interacting Genes		22 interacting genes: ACAD10 ATXN1L AXIN1 CALM1 CIB1 FEZ1 GABARAP GABARAPL2 GSK3A GSK3B ITSN2 MAP1LC3A MAP2K4 METAP1 SQSTM1 SYT4 TTN UBC UBE2D2 UBE2D3 USP8 VTA1	13 interacting genes: BRWD1 NBR1 NDUFA12 NRXN1 SGTA SGTB STX1A STX2 STX3 STX4 SYNCRIP SYT1 TFAP2B
Entrez ID		4077	6860
HPRD ID		01326	02519
Ensembl ID		ENSG00000188554	ENSG00000132872
Uniprot IDs		B7Z5R6 Q14596	Q9H2B2
PDB IDs		1WJ6 2BKF 2CP8 2G4S 2L8J 2MGW 2MJ5 4OLE	1UGK
GO Terms Enriched among Interactors		Ubiquitin Protein Ligase Binding Cellular Response To Nitrogen Starvation Beta-catenin Destruction Complex Regulation Of Protein Localization Catabolic Process Mitophagy Phosphatidylethanolamine Binding Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Macroautophagy Organelle Organization Autophagy Of Mitochondrion Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Autophagosome Regulation Of Protein Ubiquitination Regulation Of Proteasomal Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Proteolysis Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Glycogen (starch) Synthase Activity Cytosol Regulation Of Post-translational Protein Modification Positive Regulation Of Proteasomal Protein Catabolic Process Extrinsic Apoptotic Signaling Pathway Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Proteolysis Involved In Protein Catabolic Process Organelle Assembly Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Sperm Midpiece Cellular Response To Interleukin-3 Autophagy Protein-containing Complex Disassembly Autophagosome Maturation Regulation Of Establishment Of Protein Localization Positive Regulation Of Establishment Of Protein Localization Regulation Of Type B Pancreatic Cell Development Autophagosome Membrane Apoptotic Signaling Pathway Negative Regulation Of Glycogen Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Vesicle Negative Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process	SNARE Binding Vesicle Docking Organelle Localization By Membrane Tethering Membrane Docking Vesicle Fusion Neurotransmitter Transport Organelle Membrane Fusion SNAP Receptor Activity SNARE Complex Organelle Fusion Positive Regulation Of Synaptic Transmission Membrane Fusion Secretion By Cell Exocytosis Calcium-dependent Protein Binding Organelle Localization TRC Complex Secretion Vesicle Organization Membrane Organization Positive Regulation Of Regulated Secretory Pathway Cornified Envelope Assembly Membrane Assembly Establishment Of Protein Localization Positive Regulation Of Protein Localization To Plasma Membrane Modulation Of Chemical Synaptic Transmission Positive Regulation Of Protein Localization To Cell Periphery Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Endomembrane System Positive Regulation Of Catecholamine Secretion SNARE Complex Assembly Positive Regulation Of Exocytosis Positive Regulation Of Protein Localization To Membrane Glutamatergic Synapse Vesicle-mediated Transport In Synapse Cellular Localization Specific Granule Schaffer Collateral - CA1 Synapse Secretory Granule Positive Regulation Of Calcium Ion-dependent Exocytosis Vacuole Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Cell Surface Neuron Projection Positive Regulation Of Neurotransmitter Secretion Regulation Of Regulated Secretory Pathway Membrane Presynaptic Membrane Protein Heterooligomerization Regulation Of Protein Localization To Cell Periphery