NEB and TRIM63

Number of citations of the paper that reports this interaction (PMID 18157088)
41

Data Source:
BioGRID (two hybrid)

		NEB	TRIM63
Gene Name		nebulin	tripartite motif containing 63, E3 ubiquitin protein ligase
Image
Gene Ontology Annotations	Cellular Component	Cytosol Actin Cytoskeleton Z Disc Extracellular Vesicular Exosome	Nucleus Cytoplasm Microtubule Z Disc M Band
	Molecular Function	Actin Binding Protein Binding Structural Constituent Of Muscle	Ubiquitin-protein Transferase Activity Signal Transducer Activity Protein Binding Zinc Ion Binding Ligase Activity Titin Binding
	Biological Process	Muscle Organ Development Somatic Muscle Development Muscle Filament Sliding Regulation Of Actin Filament Length	Muscle Contraction Signal Transduction Regulation Of Gene Expression Skeletal Muscle Atrophy Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Interleukin-1 Cellular Response To Dexamethasone Stimulus
Pathways		Striated Muscle Contraction	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: ABI1 ACTN4 APC CALM1 DES KLHL40 MYPN TMOD1 TMOD4 TRIM55 TRIM63 TTN XIRP1 XIRP2	87 interactors: ACTA1 AK1 AKR7A2 ALDOA ANKRD1 APP ATP5B ATXN3 ATXN3L BAP1 CKB CKM DCAF6 DES EEF1G EHHADH EIF3E ENO3 ESPL1 FHL2 FLNC GFM1 GMEB1 HIBADH JOSD1 LMCD1 MRPL19 MRPL41 MYBPC1 MYBPC3 MYL2 MYOT MYOZ1 NDUFA1 NEB NEBL NOMO1 NRAP OTUB1 OTUB2 PDHB PDK4 PIAS1 PIAS2 PIAS3 PKM PSMD4 PYGM SENP2 SENP3 SQSTM1 SRF STAM SUMO2 TCAP TNNC1 TNNI1 TNNI2 TNNI3 TNNT1 TNNT3 TRIM54 TRIM55 TTN UBC UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2J1 UBE2U UCHL1 UCHL3 UCHL5 UQCRC1 USP13 USP15 USP2 USP21 USP28 USP33 USP4 USP5 USP7 USP8 UXT YOD1
Entrez ID		4703	84676
HPRD ID		01196	05843
Ensembl ID		ENSG00000183091	ENSG00000158022
Uniprot IDs		P20929 Q05C45 Q14214 Q96MF8	B4DN95 Q969Q1
PDB IDs		1ARK 1NEB	2D8U 3DDT
Enriched GO Terms of Interacting Partners?		Actin Filament-based Process Cytoskeleton Organization Actin Cytoskeleton Organization Myofibril Assembly Muscle Contraction Striated Muscle Cell Differentiation Actomyosin Structure Organization Muscle System Process Muscle Structure Development Muscle Cell Differentiation Striated Muscle Cell Development Muscle Cell Development Organelle Organization Actin Filament Organization Actin-myosin Filament Sliding Muscle Filament Sliding Actin-mediated Cell Contraction Sarcomere Organization Organelle Assembly Actin Filament-based Movement Platelet Degranulation Anatomical Structure Formation Involved In Morphogenesis Negative Regulation Of Protein Complex Disassembly Anatomical Structure Morphogenesis Pointed-end Actin Filament Capping Striated Muscle Tissue Development Regulation Of Protein Depolymerization Cell Development Muscle Tissue Development Cellular Component Assembly Regulation Of Protein Complex Disassembly Anatomical Structure Development Negative Regulation Of Cytoskeleton Organization Developmental Process Cardiac Muscle Tissue Development Platelet Activation Cell Differentiation Cell-cell Junction Organization Tissue Development Tight Junction Assembly Actin Filament Capping Positive Regulation Of Ion Transmembrane Transporter Activity Cardiac Muscle Tissue Morphogenesis Positive Regulation Of Transporter Activity Cell Activation Muscle Organ Development Negative Regulation Of Actin Filament Depolymerization Muscle Tissue Morphogenesis Regulation Of Protein Kinase Activity Organ Development	Protein Modification By Small Protein Removal Muscle Filament Sliding Actin-myosin Filament Sliding Protein Deubiquitination Actin-mediated Cell Contraction Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Actin Filament-based Movement Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein K48-linked Deubiquitination Proteolysis Muscle Contraction Regulation Of Proteasomal Protein Catabolic Process Catabolic Process Muscle System Process Regulation Of Protein Catabolic Process Actin Filament-based Process Protein K63-linked Deubiquitination Striated Muscle Cell Development Striated Muscle Contraction Muscle Cell Development Muscle Structure Development Myofibril Assembly Cellular Protein Modification Process Cellular Protein Metabolic Process Regulation Of Proteolysis Cardiac Muscle Tissue Morphogenesis Striated Muscle Cell Differentiation Muscle Tissue Morphogenesis Cardiac Muscle Tissue Development Muscle Organ Morphogenesis Actomyosin Structure Organization Protein Sumoylation Protein Metabolic Process Striated Muscle Tissue Development Muscle Cell Differentiation Muscle Tissue Development Regulation Of Muscle Contraction Protein Modification By Small Protein Conjugation Muscle Organ Development Heart Morphogenesis Regulation Of Cellular Protein Metabolic Process Cardiac Myofibril Assembly Muscle Fiber Development Monoubiquitinated Protein Deubiquitination
Tagcloud ?		accounts adds adolescence adulthood behavioural chaotic circadian compulsive conflictful conflicting daytime eaters eating eighty employment exploratory highlighted interviewed mood nes night obesity perceptions rhythm solitary standing thematic uncontrolled unemployed	benzylic bioactivation clues covalent danger dapk1 hapten hepatotoxicity il22 inflammasome marks methide nevirapine nlrp3 nvp obligate oh oxidized presumably quinone ra2 rash rashes reflecting s100a7 s100a7a sulfate travels
Tagcloud (Difference) ?		accounts adds adolescence adulthood behavioural chaotic circadian compulsive conflictful conflicting daytime eaters eating eighty employment exploratory highlighted interviewed mood nes night obesity perceptions rhythm solitary standing thematic uncontrolled unemployed	benzylic bioactivation clues covalent danger dapk1 hapten hepatotoxicity il22 inflammasome marks methide nevirapine nlrp3 nvp obligate oh oxidized presumably quinone ra2 rash rashes reflecting s100a7 s100a7a sulfate travels
Tagcloud (Intersection) ?