NEB and XIRP1

Number of citations of the paper that reports this interaction (PubMedID 23985323)
71

Data Source:
BioGRID (two hybrid, pull down)

		NEB	XIRP1
Description		nebulin	xin actin binding repeat containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Actin Cytoskeleton Myofibril Sarcomere Z Disc Contractile Muscle Fiber Extracellular Exosome	Stress Fiber Adherens Junction Focal Adhesion Cell Junction Desmosome Anchoring Junction
	Molecular Function	Actin Binding Protein Binding Structural Constituent Of Muscle Actin Filament Binding	RNA Binding Actin Binding Protein Binding Actin Filament Binding
	Biological Process	Muscle Organ Development Somatic Muscle Development Regulation Of Actin Filament Length Cardiac Muscle Thin Filament Assembly	Actin Filament Organization Intracellular Protein Localization Myoblast Differentiation Involved In Skeletal Muscle Regeneration Satellite Cell Activation Involved In Skeletal Muscle Regeneration Actin Cytoskeleton Organization Negative Regulation Of Protein Binding
Pathways		Striated Muscle Contraction
Drugs
Diseases		Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM) Nemaline myopathy
GWAS		Asparaginase-induced acute pancreatitis in acute lymphoblastic leukemia (onset time) ( 27114598) Creatine kinase levels ( 29403010) Estimated glomerular filtration rate ( 31152163 31451708) Letter-number span reordering ( 31596458) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Rapid automised naming of letters ( 30741946) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097) Skeletal muscle index ( 33674626) Squamous cell lung carcinoma ( 28604730)	Apolipoprotein A1 levels ( 32203549) Cognitive decline rate in late mild cognitive impairment ( 26252872) Daytime sleep phenotypes ( 27126917) Social communication problems ( 24564958)
Interacting Genes		25 interacting genes: ABI1 ACO1 ACTG2 ACTN4 AKTIP APC CALM1 DES ENO3 LIMS1 MTDH MYOM2 MYPN PTPN11 STRADB TMOD1 TMOD4 TPM1 TPM2 TRIM55 TRIM63 TTN USP7 XIRP1 XIRP2	9 interacting genes: ACTA1 ENAH EVL FLNC NEB NEBL RNF10 SH3RF1 VASP
Entrez ID		4703	165904
HPRD ID		01196	16727
Ensembl ID		ENSG00000183091	ENSG00000168334
Uniprot IDs		P20929 Q05C45 Q96MF8	Q702N8
PDB IDs		1ARK 1NEB 6Y17
Enriched GO Terms of Interacting Partners?		Muscle Contraction Actin Binding Actin Cytoskeleton Organization Muscle System Process Actin Filament Organization Actin Filament-based Process Actomyosin Structure Organization Supramolecular Fiber Organization Z Disc Cytoskeletal Protein Binding Cytoplasm Striated Muscle Thin Filament Actin Filament Binding Sarcomere Organization Structural Constituent Of Muscle Cytoskeleton Organization Sarcomere M Band Stress Fiber Myofibril Assembly Muscle Thin Filament Tropomyosin System Process Cytoskeleton Anchoring Junction Pointed-end Actin Filament Capping Actin Cytoskeleton Cardiac Muscle Tissue Morphogenesis Organelle Organization Actin Filament-based Movement Titin Binding Contractile Muscle Fiber Tropomyosin Binding Muscle Tissue Morphogenesis Cell Junction Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Supramolecular Fiber Organization Muscle Filament Sliding Muscle Alpha-actinin Binding Protein Kinase Regulator Activity Actin Filament Actin-myosin Filament Sliding Regulation Of Protein Depolymerization Skeletal Muscle Organ Development Protein Kinase Binding Myosin Filament Megakaryocyte Development Regulation Of Actin Filament Organization I Band Cytosol Regulation Of Protein-containing Complex Disassembly	Actin Filament Organization Actin Binding Profilin Binding Lamellipodium Supramolecular Fiber Organization Cardiac Muscle Thin Filament Assembly Actin Polymerization Or Depolymerization Filopodium Stress Fiber SH3 Domain Binding Cytoskeleton Z Disc Focal Adhesion Regulation Of Actin Filament Length Actin Filament Binding Neuron Projection Guidance Axon Guidance Structural Constituent Of Muscle Regulation Of Cellular Component Size Positive Regulation Of Actin Filament Polymerization Sarcomere Actin Cytoskeleton Protein Homotetramerization Cytoskeletal Protein Binding Protein Autoubiquitination Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Protein Polymerization Regulation Of Actin Filament-based Process Protein Tetramerization Muscle Cell Development Cytoplasm Regulation Of Actin Filament Polymerization Neuron Projection Development Somatic Muscle Development Mesenchyme Migration Regulation Of Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Skeletal Muscle Thin Filament Assembly Cell Projection Negative Regulation Of Ruffle Assembly Actin Polymerization-dependent Cell Motility Positive Regulation Of Supramolecular Fiber Organization Negative Regulation Of Schwann Cell Proliferation Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Positive Regulation Of Cytoskeleton Organization Striated Muscle Thin Filament Protein Homooligomerization Ribosome-associated Ubiquitin-dependent Protein Catabolic Process
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