NEB and ACTN4

Number of citations of the paper that reports this interaction (PMID 11882289)
16

Data Source:
HPRD (in vitro)

		NEB	ACTN4
Gene Name		nebulin	actinin, alpha 4
Image
Gene Ontology Annotations	Cellular Component	Cytosol Actin Cytoskeleton Z Disc Extracellular Vesicular Exosome	Stress Fiber Extracellular Region Extracellular Space Nucleus Cytoplasm Cell-cell Junction Focal Adhesion Z Disc Ribonucleoprotein Complex Cortical Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Neuron Projection Protein Complex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Actin Binding Protein Binding Structural Constituent Of Muscle	Nucleoside Binding Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Nuclear Hormone Receptor Binding Protein Homodimerization Activity Retinoic Acid Receptor Binding Poly(A) RNA Binding Protein N-terminus Binding Actin Filament Binding
	Biological Process	Muscle Organ Development Somatic Muscle Development Muscle Filament Sliding Regulation Of Actin Filament Length	Response To Hypoxia Platelet Degranulation Blood Coagulation Protein Transport Platelet Activation Positive Regulation Of Sodium:proton Antiporter Activity Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Apoptotic Process Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Pinocytosis Actin Filament Bundle Assembly Negative Regulation Of Cellular Component Movement Positive Regulation Of Cellular Component Movement Tight Junction Assembly Protein Localization To Tight Junction Regulation Of Nucleic Acid-templated Transcription
Pathways		Striated Muscle Contraction	Response to elevated platelet cytosolic Ca2+ Nephrin interactions Platelet degranulation Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS			Heart rate ( 23583979)
Protein-Protein Interactions		14 interactors: ABI1 ACTN4 APC CALM1 DES KLHL40 MYPN TMOD1 TMOD4 TRIM55 TRIM63 TTN XIRP1 XIRP2	43 interactors: ACTC1 ACTN3 ADORA2A ATP6V1B1 ATXN7 BMP7 CAMK2A CAMK2B CAMK2G CDKN2A COIL COL17A1 ESR1 GSN HDAC7 INO80 ITGB1 KPNA2 LRRC7 MAGI1 MAPK7 MEF2A MYOZ1 MYOZ2 NEB NOS2 NOS3 PDLIM1 POT1 PTPN11 PTPN6 RPS27 SACS SERPINE1 SLC2A4 SLC9A3R2 STAT1 TJP1 TRIM3 TXN UCHL5 USP6NL VDR
Entrez ID		4703	81
HPRD ID		01196	05222
Ensembl ID		ENSG00000183091
Uniprot IDs		P20929 Q05C45 Q14214 Q96MF8	O43707
PDB IDs		1ARK 1NEB	1WLX 1YDI 2R0O
Enriched GO Terms of Interacting Partners?		Actin Filament-based Process Cytoskeleton Organization Actin Cytoskeleton Organization Myofibril Assembly Muscle Contraction Striated Muscle Cell Differentiation Actomyosin Structure Organization Muscle System Process Muscle Structure Development Muscle Cell Differentiation Striated Muscle Cell Development Muscle Cell Development Organelle Organization Actin Filament Organization Actin-myosin Filament Sliding Muscle Filament Sliding Actin-mediated Cell Contraction Sarcomere Organization Organelle Assembly Actin Filament-based Movement Platelet Degranulation Anatomical Structure Formation Involved In Morphogenesis Negative Regulation Of Protein Complex Disassembly Anatomical Structure Morphogenesis Pointed-end Actin Filament Capping Striated Muscle Tissue Development Regulation Of Protein Depolymerization Cell Development Muscle Tissue Development Cellular Component Assembly Regulation Of Protein Complex Disassembly Anatomical Structure Development Negative Regulation Of Cytoskeleton Organization Developmental Process Cardiac Muscle Tissue Development Platelet Activation Cell Differentiation Cell-cell Junction Organization Tissue Development Tight Junction Assembly Actin Filament Capping Positive Regulation Of Ion Transmembrane Transporter Activity Cardiac Muscle Tissue Morphogenesis Positive Regulation Of Transporter Activity Cell Activation Muscle Organ Development Negative Regulation Of Actin Filament Depolymerization Muscle Tissue Morphogenesis Regulation Of Protein Kinase Activity Organ Development	Cellular Response To Organic Substance Response To Organic Substance Negative Regulation Of Signaling Response To Stress Developmental Process Cellular Response To Interferon-gamma Response To Interferon-gamma Negative Regulation Of Signal Transduction Regulation Of Cell Death Response To Abiotic Stimulus Defense Response Cellular Response To Lipid Regulation Of Signaling Regulation Of Apoptotic Process Signal Transduction Interferon-gamma-mediated Signaling Pathway Anatomical Structure Development Negative Regulation Of Cellular Metabolic Process Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Component Assembly Signaling Cellular Response To Stimulus Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Intracellular Signal Transduction Cellular Response To Hormone Stimulus Cell Communication Regulation Of Phosphorus Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Innate Immune Response Regulation Of Catalytic Activity Anatomical Structure Morphogenesis Response To Lipid Multicellular Organismal Development Response To Stimulus Regulation Of Cellular Component Organization Regulation Of Cellular Process Response To Hormone Abortive Mitotic Cell Cycle System Development Mitotic Cell Cycle Cell Differentiation Positive Regulation Of Metabolic Process Regulation Of Body Fluid Levels Cellular Response To Cytokine Stimulus G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Lipopolysaccharide
Tagcloud ?		accounts adds adolescence adulthood behavioural chaotic circadian compulsive conflictful conflicting daytime eaters eating eighty employment exploratory highlighted interviewed mood nes night obesity perceptions rhythm solitary standing thematic uncontrolled unemployed	1beta actin actinin blocks coactivator cytosol defective fails filtration focal fsgs glomerular glomerulosclerosis ikappabalpha k255e mechanistically nphs1 p50 p65 podocytes potentiate proteinuria recruit reporter segmental specialized terminally tnfalpha translocate
Tagcloud (Difference) ?		accounts adds adolescence adulthood behavioural chaotic circadian compulsive conflictful conflicting daytime eaters eating eighty employment exploratory highlighted interviewed mood nes night obesity perceptions rhythm solitary standing thematic uncontrolled unemployed	1beta actin actinin blocks coactivator cytosol defective fails filtration focal fsgs glomerular glomerulosclerosis ikappabalpha k255e mechanistically nphs1 p50 p65 podocytes potentiate proteinuria recruit reporter segmental specialized terminally tnfalpha translocate
Tagcloud (Intersection) ?