NEB and TMOD1

Number of citations of the paper that reports this interaction (PubMedID 11016930)
0

Data Source:
HPRD (in vitro, in vivo)

		NEB	TMOD1
Description		nebulin	tropomodulin 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Actin Cytoskeleton Myofibril Sarcomere Z Disc Contractile Muscle Fiber Extracellular Exosome	Cytoplasm Cytosol Cytoskeleton Striated Muscle Thin Filament Actin Filament COP9 Signalosome Membrane Myofibril Sarcomere Cortical Cytoskeleton
	Molecular Function	Actin Binding Protein Binding Structural Constituent Of Muscle Actin Filament Binding	Actin Binding Tropomyosin Binding
	Biological Process	Muscle Organ Development Somatic Muscle Development Regulation Of Actin Filament Length Cardiac Muscle Thin Filament Assembly	Muscle Contraction Actin Filament Organization Adult Locomotory Behavior Myofibril Assembly Pointed-end Actin Filament Capping Lens Fiber Cell Development
Pathways		Striated Muscle Contraction	Striated Muscle Contraction
Drugs
Diseases		Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM) Nemaline myopathy
GWAS		Asparaginase-induced acute pancreatitis in acute lymphoblastic leukemia (onset time) ( 27114598) Creatine kinase levels ( 29403010) Estimated glomerular filtration rate ( 31152163 31451708) Letter-number span reordering ( 31596458) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Rapid automised naming of letters ( 30741946) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097) Skeletal muscle index ( 33674626) Squamous cell lung carcinoma ( 28604730)	Barrett's esophagus ( 27527254) Barrett's esophagus or Esophageal adenocarcinoma ( 27527254) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Intracranial aneurysm ( 30823506) Obesity-related traits ( 23251661) Thyroid cancer (Papillary, radiation-related) ( 20350937) Zinc levels ( 26025379)
Interacting Genes		25 interacting genes: ABI1 ACO1 ACTG2 ACTN4 AKTIP APC CALM1 DES ENO3 LIMS1 MTDH MYOM2 MYPN PTPN11 STRADB TMOD1 TMOD4 TPM1 TPM2 TRIM55 TRIM63 TTN USP7 XIRP1 XIRP2	16 interacting genes: APC BUB1 CDH1 CDKN2A DCC DLC1 FBXL17 FBXW7 MLH3 NEB ODC1 PIK3CA PRKAA2 TLR2 TMSB10 TPM3
Entrez ID		4703	7111
HPRD ID		01196	01838
Ensembl ID		ENSG00000183091	ENSG00000136842
Uniprot IDs		P20929 Q05C45 Q96MF8	P28289
PDB IDs		1ARK 1NEB 6Y17	4PKG 4PKH 4PKI 4Z8G 4Z94 8F8T
Enriched GO Terms of Interacting Partners?		Muscle Contraction Actin Binding Actin Cytoskeleton Organization Muscle System Process Actin Filament Organization Actin Filament-based Process Actomyosin Structure Organization Supramolecular Fiber Organization Z Disc Cytoskeletal Protein Binding Cytoplasm Striated Muscle Thin Filament Actin Filament Binding Sarcomere Organization Structural Constituent Of Muscle Cytoskeleton Organization Sarcomere M Band Stress Fiber Myofibril Assembly Muscle Thin Filament Tropomyosin System Process Cytoskeleton Anchoring Junction Pointed-end Actin Filament Capping Actin Cytoskeleton Cardiac Muscle Tissue Morphogenesis Organelle Organization Actin Filament-based Movement Titin Binding Contractile Muscle Fiber Tropomyosin Binding Muscle Tissue Morphogenesis Cell Junction Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Supramolecular Fiber Organization Muscle Filament Sliding Muscle Alpha-actinin Binding Protein Kinase Regulator Activity Actin Filament Actin-myosin Filament Sliding Regulation Of Protein Depolymerization Skeletal Muscle Organ Development Protein Kinase Binding Myosin Filament Megakaryocyte Development Regulation Of Actin Filament Organization I Band Cytosol Regulation Of Protein-containing Complex Disassembly	Negative Regulation Of Cellular Component Organization Positive Regulation Of Protein Localization Regulation Of Protein Localization Regulation Of Cellular Component Organization Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cyclin-dependent Protein Kinase Activity Gamma-catenin Binding Regulation Of Cytoskeleton Organization Apoptotic Process Negative Regulation Of Cell Development Cell Death Programmed Cell Death Negative Regulation Of Cytoskeleton Organization Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Cell Communication Negative Regulation Of Supramolecular Fiber Organization Catenin Complex Regulation Of Protein Catabolic Process Negative Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Signaling Cytosol Postsynaptic Modulation Of Chemical Synaptic Transmission Negative Regulation Of Nervous System Development Regulation Of Organelle Organization Negative Regulation Of Cell Growth Negative Regulation Of Mitotic Nuclear Division Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Cell-matrix Adhesion Lamellipodium Sister Chromatid Cohesion Regulation Of Macroautophagy Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Histone H2A Kinase Activity Cellular Response To Oxygen-containing Compound Carbohydrate Homeostasis Glucose Homeostasis Regulation Of Protein Targeting To Mitochondrion Ligase Inhibitor Activity Supramolecular Fiber Organization Triacyl Lipopeptide Binding Regulation Of Mitotic Cell Cycle Negative Regulation Of Growth Negative Regulation Of Axonogenesis Regulation Of Apoptotic Process Cytoplasm Positive Regulation Of Apoptotic Process Regulation Of Establishment Of Protein Localization
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