NEB and TTN

Number of citations of the paper that reports this interaction (PMID 16902413)
53

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		NEB	TTN
Gene Name		nebulin	titin
Image
Gene Ontology Annotations	Cellular Component	Cytosol Actin Cytoskeleton Z Disc Extracellular Vesicular Exosome	Condensed Nuclear Chromosome Extracellular Region Cytosol Striated Muscle Thin Filament Z Disc M Band I Band Extracellular Vesicular Exosome
	Molecular Function	Actin Binding Protein Binding Structural Constituent Of Muscle	Protease Binding Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Calcium Ion Binding Protein Binding Calmodulin Binding ATP Binding Structural Constituent Of Muscle Enzyme Binding Protein Kinase Binding Telethonin Binding Identical Protein Binding Actinin Binding Protein Self-association Actin Filament Binding Muscle Alpha-actinin Binding Structural Molecule Activity Conferring Elasticity
	Biological Process	Muscle Organ Development Somatic Muscle Development Muscle Filament Sliding Regulation Of Actin Filament Length	Platelet Degranulation Cardiac Muscle Hypertrophy Muscle Contraction Striated Muscle Contraction Mitotic Chromosome Condensation Blood Coagulation Peptidyl-tyrosine Phosphorylation Muscle Filament Sliding Platelet Activation Skeletal Muscle Thin Filament Assembly Skeletal Muscle Myosin Thick Filament Assembly Detection Of Muscle Stretch Sarcomere Organization Regulation Of Protein Kinase Activity Cardiac Muscle Fiber Development Sarcomerogenesis Regulation Of Catalytic Activity Response To Calcium Ion Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction
Pathways		Striated Muscle Contraction	Striated Muscle Contraction Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS			Breast size ( 22747683) QT interval ( 20031603)
Protein-Protein Interactions		14 interactors: ABI1 ACTN4 APC CALM1 DES KLHL40 MYPN TMOD1 TMOD4 TRIM55 TRIM63 TTN XIRP1 XIRP2	29 interactors: ACTA1 ACTN1 ACTN2 ANK1 ANKRD1 ANKRD2 ANKRD23 CALM1 CAPN3 CRYAB FHL1 FHL2 FLNA MAPK1 MYBPC1 MYBPC3 MYH9 MYOM1 MYOM2 MYPN NBR1 NEB OBSCN SQSTM1 SRPK2 TCAP TRIM55 TRIM63 VAV2
Entrez ID		4703	7273
HPRD ID		01196	01787
Ensembl ID		ENSG00000183091	ENSG00000155657
Uniprot IDs		P20929 Q05C45 Q14214 Q96MF8	Q7Z3B7 Q8WZ42
PDB IDs		1ARK 1NEB	1BPV 1G1C 1NCT 1NCU 1TIT 1TIU 1TKI 1TNM 1TNN 1WAA 1YA5 2A38 2BK8 2F8V 2ILL 2J8H 2J8O 2NZI 2RQ8 2WP3 2WWK 2WWM 2Y9R 3B43 3KNB 3LCY 3LPW 3PUC 3Q5O 3QP3
Enriched GO Terms of Interacting Partners?		Actin Filament-based Process Cytoskeleton Organization Actin Cytoskeleton Organization Myofibril Assembly Muscle Contraction Striated Muscle Cell Differentiation Actomyosin Structure Organization Muscle System Process Muscle Structure Development Muscle Cell Differentiation Striated Muscle Cell Development Muscle Cell Development Organelle Organization Actin Filament Organization Actin-myosin Filament Sliding Muscle Filament Sliding Actin-mediated Cell Contraction Sarcomere Organization Organelle Assembly Actin Filament-based Movement Platelet Degranulation Anatomical Structure Formation Involved In Morphogenesis Negative Regulation Of Protein Complex Disassembly Anatomical Structure Morphogenesis Pointed-end Actin Filament Capping Striated Muscle Tissue Development Regulation Of Protein Depolymerization Cell Development Muscle Tissue Development Cellular Component Assembly Regulation Of Protein Complex Disassembly Anatomical Structure Development Negative Regulation Of Cytoskeleton Organization Developmental Process Cardiac Muscle Tissue Development Platelet Activation Cell Differentiation Cell-cell Junction Organization Tissue Development Tight Junction Assembly Actin Filament Capping Positive Regulation Of Ion Transmembrane Transporter Activity Cardiac Muscle Tissue Morphogenesis Positive Regulation Of Transporter Activity Cell Activation Muscle Organ Development Negative Regulation Of Actin Filament Depolymerization Muscle Tissue Morphogenesis Regulation Of Protein Kinase Activity Organ Development	Muscle Contraction Muscle System Process Muscle Structure Development Actin Filament-based Process Actomyosin Structure Organization Actin Filament-based Movement Actin-myosin Filament Sliding Muscle Filament Sliding Myofibril Assembly Striated Muscle Cell Differentiation Striated Muscle Cell Development Actin-mediated Cell Contraction Muscle Cell Development Sarcomere Organization Muscle Organ Development Muscle Cell Differentiation Cellular Component Assembly Actin Cytoskeleton Organization Anatomical Structure Formation Involved In Morphogenesis Anatomical Structure Morphogenesis Cytoskeleton Organization Platelet Activation Cell Differentiation Cell Development Organelle Assembly Developmental Process Anatomical Structure Development Organ Development Blood Coagulation Hemostasis System Development Multicellular Organismal Development Platelet Degranulation Striated Muscle Tissue Development Response To Stress Muscle Tissue Development Response To Abiotic Stimulus Regulation Of Apoptotic Process Response To External Stimulus Regulation Of Body Fluid Levels Organelle Organization Neurotrophin TRK Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Response To Stimulus Wound Healing Cardiovascular System Development Neurotrophin Signaling Pathway Regulation Of Cell Death Regulation Of Intracellular Transport Cell Activation
Tagcloud ?		accounts adds adolescence adulthood behavioural chaotic circadian compulsive conflictful conflicting daytime eaters eating eighty employment exploratory highlighted interviewed mood nes night obesity perceptions rhythm solitary standing thematic uncontrolled unemployed	amounts anticancer atlas braf broad diverse exome frequencies frequency frg1b harbored includes integrated lineage metastastic muc16 mutated mutational obtain omics pbrm1 resource sequencing somatic subtypes summarized ush2a varied vhl
Tagcloud (Difference) ?		accounts adds adolescence adulthood behavioural chaotic circadian compulsive conflictful conflicting daytime eaters eating eighty employment exploratory highlighted interviewed mood nes night obesity perceptions rhythm solitary standing thematic uncontrolled unemployed	amounts anticancer atlas braf broad diverse exome frequencies frequency frg1b harbored includes integrated lineage metastastic muc16 mutated mutational obtain omics pbrm1 resource sequencing somatic subtypes summarized ush2a varied vhl
Tagcloud (Intersection) ?