NEB and DES

Number of citations of the paper that reports this interaction (PMID 11309420)
43

Data Source:
BioGRID (two hybrid)
HPRD (in vitro, two hybrid)

		NEB	DES
Gene Name		nebulin	desmin
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Actin Cytoskeleton Z Disc Extracellular Vesicular Exosome	Cytosol Intermediate Filament Fascia Adherens Z Disc Neuromuscular Junction Sarcolemma Extracellular Vesicular Exosome
	Molecular Function	Actin Binding Protein Binding Structural Constituent Of Muscle	Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Protein Binding Identical Protein Binding
	Biological Process	Muscle Organ Development Somatic Muscle Development Muscle Filament Sliding Regulation Of Actin Filament Length	Muscle Contraction Cytoskeleton Organization Regulation Of Heart Contraction Muscle Filament Sliding
Pathways		Striated Muscle Contraction	Striated Muscle Contraction
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: ABI1 ACTN4 APC CALM1 DES KLHL40 MYPN TMOD1 TMOD4 TRIM55 TRIM63 TTN XIRP1 XIRP2	23 interactors: AURKB BRCA1 CAPN1 CRYAB DSP EHHADH ITSN1 MAPKAPK2 NEB PKD1 PLEKHA5 PPP1R18 ROCK1 S100A1 S100B SHBG SPTAN1 SYNC SYNM TRIM55 TRIM63 TRIM7 UBE2I
Entrez ID		4703	1674
HPRD ID		01196	00514
Ensembl ID		ENSG00000183091	ENSG00000175084
Uniprot IDs		P20929 Q05C45 Q14214 Q96MF8	P17661 Q53SB5
PDB IDs		1ARK 1NEB
Enriched GO Terms of Interacting Partners?		Actin Filament-based Process Cytoskeleton Organization Actin Cytoskeleton Organization Myofibril Assembly Muscle Contraction Striated Muscle Cell Differentiation Actomyosin Structure Organization Muscle System Process Muscle Structure Development Muscle Cell Differentiation Striated Muscle Cell Development Muscle Cell Development Organelle Organization Actin Filament Organization Actin-myosin Filament Sliding Muscle Filament Sliding Actin-mediated Cell Contraction Sarcomere Organization Organelle Assembly Actin Filament-based Movement Platelet Degranulation Anatomical Structure Formation Involved In Morphogenesis Negative Regulation Of Protein Complex Disassembly Anatomical Structure Morphogenesis Pointed-end Actin Filament Capping Striated Muscle Tissue Development Regulation Of Protein Depolymerization Cell Development Muscle Tissue Development Cellular Component Assembly Regulation Of Protein Complex Disassembly Anatomical Structure Development Negative Regulation Of Cytoskeleton Organization Developmental Process Cardiac Muscle Tissue Development Platelet Activation Cell Differentiation Cell-cell Junction Organization Tissue Development Tight Junction Assembly Actin Filament Capping Positive Regulation Of Ion Transmembrane Transporter Activity Cardiac Muscle Tissue Morphogenesis Positive Regulation Of Transporter Activity Cell Activation Muscle Organ Development Negative Regulation Of Actin Filament Depolymerization Muscle Tissue Morphogenesis Regulation Of Protein Kinase Activity Organ Development	Regulation Of Cytoskeleton Organization Intermediate Filament-based Process Apoptotic Process Programmed Cell Death Cell Death Death Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Developmental Process Response To Abiotic Stimulus Multicellular Organismal Development Muscle Contraction Execution Phase Of Apoptosis Anatomical Structure Development Muscle System Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Organelle Organization Regulation Of Cellular Component Organization Peptidyl-serine Phosphorylation Negative Regulation Of Cell Death Regulation Of Cell Death System Development Regulation Of Microtubule Cytoskeleton Organization Cytoskeleton Organization Regulation Of Actin Filament-based Process Negative Regulation Of Cytoskeleton Organization Regulation Of Microtubule-based Process G2 DNA Damage Checkpoint Negative Regulation Of Reactive Oxygen Species Metabolic Process Intermediate Filament Cytoskeleton Organization Cellular Response To Vascular Endothelial Growth Factor Stimulus Response To Lipid Response To Steroid Hormone Actin-mediated Cell Contraction Intracellular Signal Transduction Cellular Protein Modification Process Negative Regulation Of Apoptotic Process Regulation Of Angiogenesis Positive Regulation Of Histone H4-K20 Methylation Metanephric Distal Tubule Morphogenesis Positive Regulation Of Histone H4-K16 Acetylation Primary Spermatocyte Growth Positive Regulation Of SUMO Transferase Activity Negative Regulation Of Programmed Cell Death Cell Cycle Checkpoint Chromosome Segregation Axonogenesis Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Axon Development Proteasomal Protein Catabolic Process
Tagcloud ?		accounts adds adolescence adulthood behavioural chaotic circadian compulsive conflictful conflicting daytime eaters eating eighty employment exploratory highlighted interviewed mood nes night obesity perceptions rhythm solitary standing thematic uncontrolled unemployed	airways allergic arg10 asthmatic asthmatics b1 bk bronchoconstriction challenges glandular hyperreactivity inflamed kinin kinins lysylbradykinin neurally perennial permeability provocation reactivity reflexes repeated reproducible rhinitis serous sneezing surprisingly tachyphylaxis upper
Tagcloud (Difference) ?		accounts adds adolescence adulthood behavioural chaotic circadian compulsive conflictful conflicting daytime eaters eating eighty employment exploratory highlighted interviewed mood nes night obesity perceptions rhythm solitary standing thematic uncontrolled unemployed	airways allergic arg10 asthmatic asthmatics b1 bk bronchoconstriction challenges glandular hyperreactivity inflamed kinin kinins lysylbradykinin neurally perennial permeability provocation reactivity reflexes repeated reproducible rhinitis serous sneezing surprisingly tachyphylaxis upper
Tagcloud (Intersection) ?