NEB and XIRP2

Number of citations of the paper that reports this interaction (PubMedID 23985323)
71

Data Source:
BioGRID (two hybrid, pull down)

		NEB	XIRP2
Description		nebulin	xin actin binding repeat containing 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Actin Cytoskeleton Myofibril Sarcomere Z Disc Contractile Muscle Fiber Extracellular Exosome	Stress Fiber Cell-cell Junction Focal Adhesion Z Disc Cell Junction Anchoring Junction
	Molecular Function	Actin Binding Protein Binding Structural Constituent Of Muscle Actin Filament Binding	Actin Binding Protein Binding Actin Filament Binding Alpha-actinin Binding
	Biological Process	Muscle Organ Development Somatic Muscle Development Regulation Of Actin Filament Length Cardiac Muscle Thin Filament Assembly	Ventricular Septum Development Actin Filament Organization Actin Cytoskeleton Organization Cell-cell Junction Organization Cardiac Muscle Tissue Morphogenesis Regulation Of Actin Filament Organization Positive Regulation Of Protein Localization
Pathways		Striated Muscle Contraction	Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Drugs
Diseases		Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM) Nemaline myopathy
GWAS		Asparaginase-induced acute pancreatitis in acute lymphoblastic leukemia (onset time) ( 27114598) Creatine kinase levels ( 29403010) Estimated glomerular filtration rate ( 31152163 31451708) Letter-number span reordering ( 31596458) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Rapid automised naming of letters ( 30741946) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097) Skeletal muscle index ( 33674626) Squamous cell lung carcinoma ( 28604730)	Atopic dermatitis ( 25865352) Diabetic peripheral neuropathy in type 2 diabetes ( 31127053) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol levels in HIV infection ( 33109212) Plasma renin activity levels ( 29650764)
Interacting Genes		25 interacting genes: ABI1 ACO1 ACTG2 ACTN4 AKTIP APC CALM1 DES ENO3 LIMS1 MTDH MYOM2 MYPN PTPN11 STRADB TMOD1 TMOD4 TPM1 TPM2 TRIM55 TRIM63 TTN USP7 XIRP1 XIRP2	6 interacting genes: DYSF FLNC LRRK2 NEB NEBL VASP
Entrez ID		4703	129446
HPRD ID		01196	10267
Ensembl ID		ENSG00000183091	ENSG00000163092
Uniprot IDs		P20929 Q05C45 Q96MF8	A4UGR9
PDB IDs		1ARK 1NEB 6Y17	4F14
Enriched GO Terms of Interacting Partners?		Muscle Contraction Actin Binding Actin Cytoskeleton Organization Muscle System Process Actin Filament Organization Actin Filament-based Process Actomyosin Structure Organization Supramolecular Fiber Organization Z Disc Cytoskeletal Protein Binding Cytoplasm Striated Muscle Thin Filament Actin Filament Binding Sarcomere Organization Structural Constituent Of Muscle Cytoskeleton Organization Sarcomere M Band Stress Fiber Myofibril Assembly Muscle Thin Filament Tropomyosin System Process Cytoskeleton Anchoring Junction Pointed-end Actin Filament Capping Actin Cytoskeleton Cardiac Muscle Tissue Morphogenesis Organelle Organization Actin Filament-based Movement Titin Binding Contractile Muscle Fiber Tropomyosin Binding Muscle Tissue Morphogenesis Cell Junction Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Supramolecular Fiber Organization Muscle Filament Sliding Muscle Alpha-actinin Binding Protein Kinase Regulator Activity Actin Filament Actin-myosin Filament Sliding Regulation Of Protein Depolymerization Skeletal Muscle Organ Development Protein Kinase Binding Myosin Filament Megakaryocyte Development Regulation Of Actin Filament Organization I Band Cytosol Regulation Of Protein-containing Complex Disassembly	Actin Binding Cardiac Muscle Thin Filament Assembly Z Disc Actin Filament Binding Actin Filament Organization Structural Constituent Of Muscle Extracellular Exosome Cytoskeletal Protein Binding Monocyte Activation Involved In Immune Response Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Regulation Of Neurotransmitter Secretion Sarcolemma Cytoskeleton Supramolecular Fiber Organization Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion Beta-catenin Destruction Complex Binding Regulation Of Actin Filament Length Synaptic Vesicle Membrane Positive Regulation Of Protein Autoubiquitination Response To Curcumin Somatic Muscle Development Cytoplasmic Side Of Mitochondrial Outer Membrane Positive Regulation Of Dopamine Receptor Signaling Pathway Multivesicular Body, Internal Vesicle Regulation Of CAMKK-AMPK Signaling Cascade Regulation Of Branching Morphogenesis Of A Nerve Regulation Of Synaptic Vesicle Transport Regulation Of Protein Autoubiquitination Positive Regulation Of Synaptic Vesicle Endocytosis Negative Regulation Of Protein Targeting To Mitochondrion Regulation Of Kidney Size Tangential Migration From The Subventricular Zone To The Olfactory Bulb Positive Regulation Of Synaptic Vesicle Recycling Cellular Response To Dopamine Intracellular Distribution Of Mitochondria Regulation Of Retrograde Transport, Endosome To Golgi Postsynapse Positive Regulation Of Microglial Cell Activation Protein Localization To Endoplasmic Reticulum Exit Site Negative Regulation Of Establishment Of Protein Localization To Mitochondrion Response To Dopamine Regulation Of Cellular Component Size JUN Kinase Kinase Kinase Activity Regulation Of Neuron Maturation
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